1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Sematilide hydrochloride

Sematilide hydrochloride (Synonyms: CK-1752 hydrochloride)

Cat. No.: HY-101436A
Handling Instructions

Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent.

For research use only. We do not sell to patients.

Sematilide hydrochloride Chemical Structure

Sematilide hydrochloride Chemical Structure

CAS No. : 101526-62-9

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Description

Sematilide hydrochloride (CK-1752 hydrochloride) is a selective IKr channel blocker. Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM). Sematilide is a class III antiarrhythmic agent[1].

IC50 & Target

IC50: 25 μM (K+ current)[1]

In Vitro

Application of 10, 30, 100 and 300 μM Sematilide causes a concentration-dependent inhibition of the delayed rectifier K+ current (IC50=25 μM)[1].

In Vivo

Sematilide (0.3-1.0 mg/kg, intravenously i.v.) is effective in a canine model of arrhythmia[2].

Animal Model: Mongrel dogs of either sex (10-18 kg body weight)[2]
Dosage: 0.3, 1, 3, and 10 mg/kg
Administration: I.v. infusions
Result: Demonstrated antiarrhythmic effects at 0.3 and 3.0 mg/kg.
Molecular Weight

349.88

Formula

C₁₄H₂₄ClN₃O₃S

CAS No.

101526-62-9

SMILES

O=C(NCCN(CC)CC)C1=CC=C(NS(=O)(C)=O)C=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SematilideCK-1752CK1752CK 1752Potassium ChannelKcsAIKrchannelblockercurrentantiarrhythmicInhibitorinhibitorinhibit

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Sematilide hydrochloride
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