1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Nifekalant hydrochloride

Nifekalant hydrochloride (Synonyms: MS-551)

Cat. No.: HY-B0772A
Handling Instructions

Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC50 of 10 µM. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research.

For research use only. We do not sell to patients.

Nifekalant hydrochloride Chemical Structure

Nifekalant hydrochloride Chemical Structure

CAS No. : 130656-51-8

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Description

Nifekalant hydrochloride (MS-551), a class III antiarrhythmic agent, is a IKr potassium channel blocker with an IC50 of 10 µM. Nifekalant hydrochloride can be used for refractory ventricular tachyarrhythmias research[1][2].

In Vitro

Nifekalant interacts with the cardiac M2 and the peripheral M3 receptors with a Ki value of 27 and 74 mM, respectively. Nifekalant dose dependently blocks HERG channels with an IC50 value of 7.9 mM, but Nifekalant does not block minK currents in the Xenopus oocyte expression system. Nifekalant blocks HERG channels mainly in their open state in a frequency dependent manner. As a pure K+ channel blocker, Nifekalant does not have negative inotropic effects which amiodarone has via a β-blocking action and does not affect cardiac conduction[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In rats (a species deficient in functional cardiac IK), before coronary ligation, 3 mg/kg and 10 mg/kg MS-551 decreased the heart rate by 6% and 12%, and increased mean arterial pressure (MAP) by 14% and 33%, respectively. MS-551 prolongs the QT interval and reduced the incidence of sustained ventricular fibrillation (VF) after reperfusion[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

441.91

Formula

C₁₉H₂₈ClN₅O₅

CAS No.
SMILES

[H]Cl.O=C1N(C)C(C=C(NCCN(CCO)CCCC2=CC=C([N+]([O-])=O)C=C2)N1C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

NifekalantMS-551MS551MS 551Potassium ChannelKcsAantiarrhythmicIKrventriculartachyarrhythmias,Inhibitorinhibitorinhibit

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Nifekalant hydrochloride
Cat. No.:
HY-B0772A
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