Pilsicainide hydrochloride
Based on 1 Customer Validation
Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent.
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- Reinheit: 99.45%
- CAS. Nr.: 88069-49-2
- Formel: C17H25ClN2O
- Molecular Weight:308.85
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Speicherung:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
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Biologische Aktivität
Pilsicainide hydrochloride (SUN-1165) (10-200 μg/mL) decreases peak amplitude of the net inward current in a dose-dependent manner with an IC50 of 29.2 ± 22.9 μg/mL in levo-thyroxine (T4)-treated rat atrial cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male Sprague-Dawley (SD) rats weighing from 200 to 220 g, with levo-thyroxine (T4) treatment[1]
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Dosage:2 mg/kg
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Administration:Bolus injection into right external carotid vein within 2 minutes, once
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Result:Result: the QT interval was significantly elongated at 15 and 60 minutes after administration. P wave and QRS complex durations were significantly shortened. Markedly decreased action potential amplitudes (APA) and Max dV/dt, and significantly lengthened the action potential durations.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS. Nr. 88069-49-2
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Appearance Solid
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Molecular Weight 308.85
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Formel C17H25ClN2O
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Color White to off-white
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SMILES
O=C(CC12N(CCC2)CCC1)NC3=C(C)C=CC=C3C.Cl
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Synonyms
SUN-1165; Pilzicainidehydrochloride
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Structure Classification
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Lösungsmittel & Löslichkeit
H2O : 100 mg/mL (323.78 mM; Need ultrasonic)
DMSO : 50 mg/mL (161.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (277 KB)
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SDS (420 KB)
- English - EN (420 KB)
- Français - FR (420 KB)
- Deutsch - DE (420 KB)
- Norwegian - NO (420 KB)
- Español - ES (420 KB)
- Swedish - SV (420 KB)
- Italian - IT (420 KB)
- Korean - KR (420 KB)
- Portuguese - PT (420 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.2378 mL | 16.1889 mL | 32.3779 mL | 80.9447 mL |
| 5 mM | 0.6476 mL | 3.2378 mL | 6.4756 mL | 16.1889 mL | |
| 10 mM | 0.3238 mL | 1.6189 mL | 3.2378 mL | 8.0945 mL | |
| 15 mM | 0.2159 mL | 1.0793 mL | 2.1585 mL | 5.3963 mL | |
| 20 mM | 0.1619 mL | 0.8094 mL | 1.6189 mL | 4.0472 mL | |
| 25 mM | 0.1295 mL | 0.6476 mL | 1.2951 mL | 3.2378 mL | |
| 30 mM | 0.1079 mL | 0.5396 mL | 1.0793 mL | 2.6982 mL | |
| 40 mM | 0.0809 mL | 0.4047 mL | 0.8094 mL | 2.0236 mL | |
| 50 mM | 0.0648 mL | 0.3238 mL | 0.6476 mL | 1.6189 mL | |
| 60 mM | 0.0540 mL | 0.2698 mL | 0.5396 mL | 1.3491 mL | |
| 80 mM | 0.0405 mL | 0.2024 mL | 0.4047 mL | 1.0118 mL | |
| 100 mM | 0.0324 mL | 0.1619 mL | 0.3238 mL | 0.8094 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Pilsicainide hydrochloride Related Classifications
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