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Cat. No.: HY-14186

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KVI-020

(Synonyms: WYE-160020)

KVI-020 is an orally active, potent and selective blocker of the atrial potassium channel Kv1.5, with an IC₅₀ of 480 nM. KVI-020 can inhibits hERG, with an IC₅₀ of 15100 nM. KVI-020 is a potent antiarrhythmic agent, and can be used for atrial fibrillation (AF) research.

For research use only. We do not sell to patients.

CAS No.: 1000306-34-2
Formula: C₂₀H₂₅N₃O₅S
Molecular Weight:419.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

KVI-020 Chemical Structure

CAS No.: 1000306-34-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC₅₀: 480 ± 44 nM (Kv1.5), 15100 nM (hERG)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	>30 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Cav1.2 expressed in CHO cells by patch-clamp technique Inhibition of Cav1.2 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	>30 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Nav1.5 expressed in CHO cells by patch-clamp technique Inhibition of Nav1.5 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	1.41 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Kv1.3 expressed in CHO cells by patch-clamp technique Inhibition of Kv1.3 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	2.66 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Kv1.1 expressed in CHO cells by patch-clamp technique Inhibition of Kv1.1 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	23.4 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Cav1.3 expressed in CHO cells by patch-clamp technique Inhibition of Cav1.3 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	3.87 μM Compound: 4g, KVI-020, WYE-160020	Inhibition of Kv4.3 expressed in CHO cells by patch-clamp technique Inhibition of Kv4.3 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]
CHO	IC₅₀	480 nM Compound: 4g, KVI-020, WYE-160020	Inhibition of human Kv1.5 expressed in CHO cells by patch-clamp technique Inhibition of human Kv1.5 expressed in CHO cells by patch-clamp technique	[PMID: 19888755]

Chemical Information

CAS No. 1000306-34-2
Molecular Weight 419.49
Formula C₂₀H₂₅N₃O₅S
SMILES

O=C1N([C@@](C(C=C2)=CC=C2OC)([H])CN1N[S](C)(=O)=O)CCC(C=C3)=CC=C3OC
Synonyms

WYE-160020
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Blass BE, et al. Selective Kv1.5 blockers: development of (R)-1-(methylsulfonylamino)-3-[2-(4-methoxyphenyl)ethyl]-4-(4-methoxyphenyl)-2-imidazolidinone (KVI-020/WYE-160020) as a potential treatment for atrial arrhythmia. J Med Chem. 2009 Nov 12;52(21):65 [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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