1. Membrane Transporter/Ion Channel
  2. Potassium Channel

Almokalant (Synonyms: H 234​/09)

Cat. No.: HY-106855
Handling Instructions

Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.

For research use only. We do not sell to patients.

Almokalant Chemical Structure

Almokalant Chemical Structure

CAS No. : 123955-10-2

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current.

IC50 & Target

Potassium channel[1]

In Vitro

Almokalant is a class III antiarrhythmic drug, acts as a potassium channel blocker, and inhibits a specific component (Ikr) of the time-dependent delayed rectifier K+ current[1].

In Vivo

Almokalant (125 μmol/kg, p.o.) induces cardiovascular defects, orofacial clefts, and tail defects in pregnant rats, after administration on Day 11. Almokalant also causes in pregnant rats[1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8370 mL 14.1848 mL 28.3696 mL
5 mM 0.5674 mL 2.8370 mL 5.6739 mL
10 mM 0.2837 mL 1.4185 mL 2.8370 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

352.49

Formula

C₁₈H₂₈N₂O₃S

CAS No.

123955-10-2

SMILES

CCCS(CCCN(CC)CC(O)COC1=CC=C(C#N)C=C1)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Almokalant
Cat. No.:
HY-106855
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Almokalant

Cat. No.: HY-106855