1. Recombinant Proteins
  2. Recombinant Human alpha-Galactosidase A, His (HEK293-expressed)

Recombinant Human alpha-Galactosidase A, His (HEK293-expressed)

Cat. No.: HY-P7492
Handling Instructions

Recombinant Human alpha-Galactosidase A, His (HEK293-expressed), a recombinant human alpha-Galactosidase A produced in HEK293 cells, has a His tag at the C-terminus. Recombinant Human alpha-Galactosidase A is the lysosomal exoglycosidase responsible for the hydrolysis of terminal α-galactosyl residues from glycoconjugates and is the defective enzyme causing Fabry disease[1].

For research use only. We do not sell to patients.

Recombinant Proteins

Recombinant Proteins-MedChemExpress
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10 μg $180 Ask For Quote & Lead Time
50 μg $550 Ask For Quote & Lead Time

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  • Technical Parameters

  • Properties

  • Description

Synonyms
rHualpha-Galactosidase A, His; GLA; alpha-Galactosidase A
Species

Human

Source

HEK 293

Accession

P06280

Gene ID

2717

Molecular Weight

50-60 kDa

AA Sequence

LDNGLARTPT MGWLHWERFM CNLDCQEEPD SCISEKLFME MAELMVSEGW KDAGYEYLCI DDCWMAPQRD SEGRLQADPQ RFPHGIRQLA NYVHSKGLKL GIYADVGNKT CAGFPGSFGY YDIDAQTFAD WGVDLLKFDG CYCDSLENLA DGYKHMSLAL NRTGRSIVYS CEWPLYMWPF QKPNYTEIRQ YCNHWRNFAD IDDSWKSIKS ILDWTSFNQE RIVDVAGPGG WNDPDMLVIG NFGLSWNQQV TQMALWAIMA APLFMSNDLR HISPQAKALL QDKDVIAINQ DPLGKQGYQL RQGDNFEVWE RPLSGLAWAV AMINRQEIGG PRSYTIAVAS LGKGVACNPA CFITQLLPVK RKLGFYEWTS RLRSHINPTG TVLLQLENTM QMSLKDLLHH HHHH

Biological Activity
Data is not available.
Appearance

Solution

Formulation

Supplied as a 0.2 μm filter solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A

Storage & Stability

Recombinant Human alpha-Galactosidase A, His (HEK293-expressed) (rHualpha-Galactosidase A, His) is stored at -20°C. It is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Shipping with dry ice.

Background

alpha-Galactosidase A (α-GAL, also known as α-GAL A) is responsible for the breakdown of α-galactosides in the lysosome. Defects in human alpha-Galactosidase A lead to the development of Fabry disease, a lysosomal storage disorder characterized by the buildup of α-galactosylated substrates in the tissues. alpha-Galactosidase A is an active target of clinical research: there are currently two treatment options for Fabry disease, recombinant enzyme replacement therapy and pharmacological chaperone therapy[2].

Documentation
References
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Product Name:
Recombinant Human alpha-Galactosidase A, His (HEK293-expressed)
Cat. No.:
HY-P7492
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