1. Metabolic Enzyme/Protease
  2. Phospholipase
  3. Lp-PLA2-IN-3

Lp-PLA2-IN-3 

Cat. No.: HY-133149
Handling Instructions

Lp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 of 14 nM for recombinant human Lp-PLA2 (rhLpPLA2).

For research use only. We do not sell to patients.

Lp-PLA2-IN-3 Chemical Structure

Lp-PLA2-IN-3 Chemical Structure

CAS No. : 2196245-16-4

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Description

Lp-PLA2-IN-3 is a potent and orally bioavailable lipoprotein-associated phospholipase A2 (Lp-PLA2) inhibitor, with an IC50 of 14 nM for recombinant human Lp-PLA2 (rhLpPLA2)[1].

In Vivo

Lp-PLA2-IN-3 (3 mg/kg; p.o.) treatment shows the Cmax, AUC0-24h, t1/2 and F were 0.27 μg/mL, 3.4 μg h/mL, 7.7 hours and 35.5%, respectively[1].
Lp-PLA2-IN-3 (1 mg/kg; i.v.) treatment shows the CL, Vss, and t1/2 were 3.1mL/min/kg, 0.3 L/kg, 4 hours, respectively[1].

Animal Model: Male Sprague−Dawley (SD) rats (180-220 g)[1]
Dosage: 3 mg/kg
Administration: p.o. (Pharmacokinetic Analysis)
Result: The Cmax, AUC0-24h, t1/2 and F were 0.27 μg/mL, 6.2 μg h/mL, 7.7 hours and 35.5%, respectively.
Molecular Weight

467.85

Formula

C₂₀H₁₃ClF₃N₃O₃S

CAS No.

2196245-16-4

SMILES

O=S(C1=CC=C(N)C=C1)(NC2=CC=C(OC3=CC=C(Cl)C(C(F)(F)F)=C3)C(C#N)=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

Lp-PLA2-IN-3PhospholipaseInhibitorinhibitorinhibit

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