1. Metabolic Enzyme/Protease
  2. Fatty Acid Synthase (FAS)

FT113 

Cat. No.: HY-111551
Handling Instructions

FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer both in vitro and in vivo.

For research use only. We do not sell to patients.

FT113 Chemical Structure

FT113 Chemical Structure

CAS No. : 1630808-89-7

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer both in vitro and in vivo[1].

IC50 & Target

IC50: 213 nM (FASN), 90 nM (FASN, in BT474 cell)[1]

In Vitro

FT113 shows anti-proliferative activity against PC3 and MV-411 cells with IC50s of 47 and 26 nM, respectively[1].

In Vivo

FT113 (5 mg/kg, p.o.) exhibits potent oral bioavailability of 95% and 84% in mice and rats, respectively[1].
FT113 (5, 25, or 50 mg/kg, p.o., twice daily for 16 days) increases malonyl-CoA concentration in tumors, inhibits tumor growth in a dose-dependent manner in mice[1].

Animal Model: Athymic nude mice bearing MV-411 cells[1]
Dosage: 5, 25, or 50 mg/kg
Administration: P.O., twice daily for 16 days
Result: Caused 32 % and 50% tumor growth inhibition at 25 and 50 mg/kg, respectively in mice.
References
Molecular Weight

409.41

Formula

C₂₂H₂₀FN₃O₄

CAS No.

1630808-89-7

SMILES

O=C(C1(CC1)O)N2CCN(C(C3=CC=C(C4=NC5=C(C=C(F)C=C5)O4)C=C3)=O)CC2

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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FT113
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FT113

Cat. No.: HY-111551