1630808-89-7
Chemical Structure
FT113
- CAS No.: 1630808-89-7
- Formula:C22H20FN3O4
- Molecular Weight:409.41
IUPAC Name: (4-(4-(6-fluorobenzo[d]oxazol-2-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone
InChIKey: DSTWHRGOCUOKDE-UHFFFAOYSA-N
SMILES: O=C(C1(CC1)O)N2CCN(C(C3=CC=C(C4=NC5=C(C=C(F)C=C5)O4)C=C3)=O)CC2
Biological Activity: FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo[1].
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FT113 | 99.39% | FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo. | ||||||||||||||||||||
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Keywords
