1630808-89-7
Chemical Structure
FT113
- CAS No.: 1630808-89-7
- Formula:C22H20FN3O4
- Molecular Weight:409.41
IUPAC Name: (4-(4-(6-fluorobenzo[d]oxazol-2-yl)benzoyl)piperazin-1-yl)(1-hydroxycyclopropyl)methanone
InChIKey: DSTWHRGOCUOKDE-UHFFFAOYSA-N
SMILES: O=C(C1(CC1)O)N2CCN(C(C3=CC=C(C4=NC5=C(C=C(F)C=C5)O4)C=C3)=O)CC2
Biological Activity: FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
FT113 | 99.39% | FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
FT113 (Standard) | ≥98% | FT113 (Standard) is the analytical standard of FT113 (HY-111551). This product is intended for research and analytical applications. FT113 is a potent and orally active fatty acid synthase (FASN) inhibitor, with an IC50 of 213 nM for full-length recombinant human FASN enzyme. In cell-based assay, FT113 blocks FASN activity in BT474 cells (IC50, 90 nM). FT113 shows anti-proliferative activity, and exhibits anti-cancer activity both in vitro and in vivo. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
-
Similarity Score 0.51
HY-116873Flunoxaprofen -
Similarity Score 0.51
HY-144270Glucosylceramide synthase-IN-3 -
Similarity Score 0.51
HY-151625PARP-2-IN-3 -
Similarity Score 0.51
HY-12756ARE6446 dihydrochloride (Standard) -
Similarity Score 0.51
HY-12756E6446 -
Similarity Score 0.50
HY-117006E1231 -
Similarity Score 0.49
HY-153833PDS-0330 -
Similarity Score 0.49
HY-184376Antiparasitic agent-43 -
Similarity Score 0.49
HY-173336MAO-B-IN-42 -
Explore the MedChemAI to find more analogs
