1. Metabolic Enzyme/Protease
  2. PAI-1
  3. Toddalolactone

Toddalolactone 

Cat. No.: HY-N0518
Handling Instructions

Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM.

For research use only. We do not sell to patients.

Toddalolactone Chemical Structure

Toddalolactone Chemical Structure

CAS No. : 483-90-9

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Description

Toddalolactone, a main component of Toddalia asiatica, inhibits the activity of recombinant human plasminogen activator inhibitor-1 (PAI-1), with an IC50 value of 37.31 μM[1].

In Vitro

Toddalolactone, a natural coumarin, inhibits PAI-1 activity by preventing the formation of a stable PAI-1/uPA covalent complex, suggesting that the inhibitory effect of Toddalolactone may be due to the interference of close contact between plasminogen activator and the active center of PAI-1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

308.33

Formula

C₁₆H₂₀O₆

CAS No.

483-90-9

SMILES

O=C1C=CC2=C(OC)C(C[[email protected]@H](O)C(C)(O)C)=C(OC)C=C2O1

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

ToddalolactonePAI-1Plasminogen activator inhibitor-1bloodcirculationstasiscoumarin thrombosisfibrosisInhibitorinhibitorinhibit

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