1. Metabolic Enzyme/Protease
  2. Phosphodiesterase (PDE)
  3. Enpp-1-IN-14

Enpp-1-IN-14 

Cat. No.: HY-147389
Handling Instructions

ENPP1-IN-2 is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity.

For research use only. We do not sell to patients.

Enpp-1-IN-14 Chemical Structure

Enpp-1-IN-14 Chemical Structure

CAS No. : 2687222-59-7

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Description

ENPP1-IN-2 is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC50 value of 32.38 nM for recombinant human ENPP-1. ENPP1-IN-2 has anti-tumor activity[1].

IC50 & Target

IC50: 32.38 nM (recombinant human ENPP-1)[1]

In Vivo

ENPP1-IN-2 (compound 015) (50 mg/kg; IP; BID, for 31 days) significantly inhibits tumor growth[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells)[1]
Dosage: 50 mg/kg
Administration: IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site)
Result: Significantly inhibited tumor growth.
Molecular Weight

403.88

Formula

C15H22ClN5O4S

CAS No.
SMILES

O=S(N)(N1CCN(CCC1)C2=C3C=C(OC)C(OC)=CC3=NC=N2)=O.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Enpp-1-IN-14
Cat. No.:
HY-147389
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