Enpp-1-IN-14
Based on 1 publication(s) in Google Scholar
Enpp-1-IN-14 (Compound 015) is a potent Ectonucleotide Pyrophosphatase/Phosphodiesterase-1 (ENPP1) inhibitor with an IC50 value of 32.38 nM for recombinant human ENPP-1. Enpp-1-IN-14 has anti-tumor activity.
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 2687222-59-7
- Formula: C15H22ClN5O4S
- Molecular Weight:403.88
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Enpp-1-IN-14
More
Biological Activity
IC50: 32.38 nM (recombinant human ENPP-1)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female C57BL/6 mice (4-6 weeks; implanted subcutaneously with 2×105 MC38 cells)[1]
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Dosage:50 mg/kg
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Administration:IP; BID, for 31 days (given a single 10 Gy exposure of focal radiation to the tumor site)
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Result:Significantly inhibited tumor growth.
Chemical Information
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CAS No. 2687222-59-7
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Appearance Solid
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Molecular Weight 403.88
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Formula C15H22ClN5O4S
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Color White to off-white
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SMILES
O=S(N)(N1CCN(CCC1)C2=C3C=C(OC)C(OC)=CC3=NC=N2)=O.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Immunity
Membrane integrity changes upon viral infection activate sphingomyelinase SMPDL3B to restrict cGAS-STING signaling via cGAMP degradation. [Abstract]2025 Nov 11;58(11):2670-2684.e10. PMID: 41175872
Solvent & Solubility
DMSO : 9.62 mg/mL (23.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 50% PEG300 50% Saline
Solubility: 10 mg/mL (24.76 mM); Suspended solution; Need ultrasonic and warming and heat to 42°C
Purity & Documentation
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Data Sheet (278 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4760 mL | 12.3799 mL | 24.7598 mL | 61.8996 mL |
| 5 mM | 0.4952 mL | 2.4760 mL | 4.9520 mL | 12.3799 mL | |
| 10 mM | 0.2476 mL | 1.2380 mL | 2.4760 mL | 6.1900 mL | |
| 15 mM | 0.1651 mL | 0.8253 mL | 1.6507 mL | 4.1266 mL | |
| 20 mM | 0.1238 mL | 0.6190 mL | 1.2380 mL | 3.0950 mL |
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