2. Anti-infection
  3. RSV
  4. Nirsevimab

Nirsevimab  (Synonyms: MEDI8897)

製品番号: HY-P99756 純度: 98.00%
COA Technical Support

Nirsevimab (MEDI8897) is a recombinant monoclonal antibody against human respiratory syncytial virus (RSV). Nirsevimab has neutralizing activity against RSV A and RSV B viruses, with IC50 values of 5.42 ng/mL and 9.71 ng/mL, respectively. Nirsevimab can be used for research on respiratory infections.

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CAS 番号 : 1989556-22-0

容量 価格（税別） 在庫状況 数量
>無料サンプル (100 μg)   今すぐ申し込む  
1 mg $615 在庫あり
5 mg $1600 在庫あり
10 mg $2560 在庫あり
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100 mg   お問い合わせ  

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Nirsevimab 関連抗体

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製品説明

Nirsevimab (MEDI8897) is a recombinant monoclonal antibody against human respiratory syncytial virus (RSV). Nirsevimab has neutralizing activity against RSV A and RSV B viruses, with IC50 values of 5.42 ng/mL and 9.71 ng/mL, respectively. Nirsevimab can be used for research on respiratory infections[1][2].
Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

RSV-F
体外実験

Nirsevimab can directly neutralize RSV virus and has fragment crystallizable (Fc) - mediated effector function, thereby preventing respiratory infections[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Nirsevimab 関連抗体
体内実験

Nirsevimab (10-10000 μg/kg; i.m.) inhibits the antibody response in the respiratory mucosa of mice when pre-administered prior to RSV virus infection[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 3-week-old female BALB/c mice[2].
Dosage: 10 μg/kg, 100 μg/kg, 1 mg/kg, 10 mg/kg
Administration: Intramuscular injection (i.m.); administer medication 24 hours prior to RSV virus exposure
Result: Inhibited the secretion of sIgA, mucosal IgA, and mucosal IgG in the offspring subsequent to the initial RSV infection.
臨床実験
Accession

A0A0X8XRK2
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

146.31 kDa

CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Nirsevimab]
輸送条件

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Fusion glycoprotein F0/F Protein, HRSV (sf9, His, HY-P75182) can bind Nirsevimab. The EC50 for this effect is 44 ng/mL.
純度とドキュメンテーション
参考文献
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Nirsevimab Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nirsevimab1989556-22-0MEDI8897MEDI 8897MEDI-8897RSVRespiratory syncytial virusantibodyrespiratory tract infectionInhibitorinhibitorinhibit

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製品名:
Nirsevimab
製品番号:
HY-P99756
数量:
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