1. GPCR/G Protein
    Neuronal Signaling
  2. Cannabinoid Receptor
  3. BAY 38-7271

BAY 38-7271 

Cat. No.: HY-119744
Handling Instructions

BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist, with Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 receptor, respectively. BAY 38-7271 has strong neuroprotective properties.

For research use only. We do not sell to patients.

BAY 38-7271 Chemical Structure

BAY 38-7271 Chemical Structure

CAS No. : 212188-60-8

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Description

BAY 38-7271 is selective and highly potent and cannabinoid CB1/CB2 receptor agonist, with Kis of 1.85 nM and 5.96 nM for recombinant human CB1 receptor and CB2 receptor, respectively. BAY 38-7271 has strong neuroprotective properties[1].

IC50 & Target

CB1

1.85 nM (Ki)

CB2

5.96 nM (Ki)

In Vitro

BAY 38-7271 shows only minor interactions at the micromolar range with other binding sites such as adenosine A3 receptor (IC50 = 7.5 μM), peripheral GABAA benzodiazepine receptor (IC50 = 971 nM), melatonin ML1 receptor (IC50 = 3.3 μM), and at the monoamine transporter (IC50 = 1.7 μM)[1].

In Vivo

BAY 38-7271 (Ed50 = 0.02 mg/kg; i.v. and 0.5 mg/kg; i.p.) induces a potent and dose-de-pendent reduction in core body temperature[1].
BAY 38-7271 has low physical dependence liability and is not essentially different from that of other cannabinoid CB1 receptor agonists[1].
BAY 38-7271 (1-1000 ng/kg/h; i.v. infusion; for 4 hours) shows neuroprotective efficacy in the rat SDH model[1].
BAY 38-7271 also has neuroprotective efficacy in models of transient and permanent occlusion of the middle cerebral artery and brain edema models[1].

Animal Model: Wistar rat ,TBI rat models (acute subdural hematoma, SDH)[1]
Dosage: 1 ng/kg/h, 10 ng/kg/h, 100 ng/kg/h, 1000 ng/kg/h
Administration: Intravenous infusion, for 4 hours
Result: Reduced the mean infarct volume.
Molecular Weight

430.44

Formula

C₂₀H₂₁F₃O₅S

CAS No.

212188-60-8

SMILES

O=S(CCCC(F)(F)F)(OC1=CC=CC(OC2=CC=CC3=C2C[[email protected]](CO)C3)=C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

BAY 38-7271Cannabinoid ReceptortraumaticbraininjuryTBIcerebralischemiaacutesubduralhematomaSDHInhibitorinhibitorinhibit

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BAY 38-7271
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HY-119744
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