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Alpha-Glucosidase+Inhibitors

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Aldose Reductase (1) Amylases (7) Antibiotic (5) Apoptosis (2) Aryl Hydrocarbon Receptor (1) Aurora Kinase (1) Bacterial (6) Bcl-2 Family (1) c-Kit (1) Cytochrome P450 (1) Dipeptidyl Peptidase (1) Drug Intermediate (2) Endogenous Metabolite (3) Enterovirus (1) Environmental Pollutants (2) Estrogen Receptor/ERR (3) Glutaminase (1) Glycosidase (154) Isotope-Labeled Compounds (2) MMP (1) NO Synthase (1) P-glycoprotein (1) Phosphatase (2) Phosphodiesterase (PDE) (2) Phospholipase (1) PI3K (3) Reactive Oxygen Species (ROS) (1) Reference Standards (10) SARS-CoV (1) VEGFR (1)
By Research Areas:	Cancer (16) Cardiovascular Disease (3) Endocrinology (1) Infection (16) Inflammation/Immunology (13) Metabolic Disease (136) Neurological Disease (5)

By Targets:

Aldose Reductase (1)

Amylases (7)

Antibiotic (5)

Apoptosis (2)

Aryl Hydrocarbon Receptor (1)

Aurora Kinase (1)

Bacterial (6)

Bcl-2 Family (1)

c-Kit (1)

Cytochrome P450 (1)

Dipeptidyl Peptidase (1)

Drug Intermediate (2)

Endogenous Metabolite (3)

Enterovirus (1)

Environmental Pollutants (2)

Estrogen Receptor/ERR (3)

Glutaminase (1)

Glycosidase (154)

Isotope-Labeled Compounds (2)

MMP (1)

NO Synthase (1)

P-glycoprotein (1)

Phosphatase (2)

Phosphodiesterase (PDE) (2)

Phospholipase (1)

PI3K (3)

Reactive Oxygen Species (ROS) (1)

Reference Standards (10)

SARS-CoV (1)

VEGFR (1)

By Research Areas:

Cancer (16)

Cardiovascular Disease (3)

Endocrinology (1)

Infection (16)

Inflammation/Immunology (13)

Metabolic Disease (136)

Neurological Disease (5)

163

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0089

Acarbose Maximum Cited Publications 10 Publications Verification BAY g 5421	Glycosidase	Infection Metabolic Disease Cancer
Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active *alpha-glucosidase* inhibitor (IC₅₀=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-14860

1-Deoxynojirimycin 5+ Cited Publications Duvoglustat	Glycosidase PI3K	Metabolic Disease
1-Deoxynojirimycin (Duvoglustat) is a potent and orally active *α-glucosidase* inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features .

HY-14860A

1-Deoxynojirimycin hydrochloride 5+ Cited Publications Duvoglustat hydrochloride	Glycosidase PI3K Bacterial Antibiotic	Infection Metabolic Disease
1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active *α-glucosidase* inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features .

HY-N7096

Ceftezole sodium CTZ sodium	Bacterial Antibiotic	Infection
Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-125713

Ganoderic acid Y	Glycosidase Enterovirus	Infection
Ganoderic acid Y is a *α-glucosidase* inhibitor with an IC₅₀ of 170 μM for yeast α-glucosidase. Ganoderic acid Y inhibits enterovirus 71 (EV71) replication through blocking EV71 uncoating .

HY-78000

Methyl 4-formylbenzoate 4-Carbomethoxybenzaldehyde; 4-Carboxybenzaldehyde methyl ester; Terephthalaldehydic acid methyl ester; Methyl 4-formylbenzoate	Drug Intermediate	Metabolic Disease
Methyl 4-formylbenzoate (4-Carbomethoxybenzaldehyde; 4-Carboxybenzaldehyde methyl ester; Terephthalaldehydic acid methyl ester; Methyl 4-formylbenzoate) is a intermediate that can be used for the synthesis of chalcone amide α-glucosidase inhibitors .

HY-N7377

Butyl isobutyl phthalate	Glycosidase	Metabolic Disease
Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive *α-glucosidase* inhibitor with an IC₅₀ value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment .

HY-B0089R

Acarbose (Standard) BAY g 5421 (Standard)	Reference Standards Glycosidase	Metabolic Disease Cancer
Acarbose (Standard) is the analytical standard of Acarbose. This product is intended for research and analytical applications. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-N8517

Malabaricone B	Glycosidase Apoptosis	Infection Metabolic Disease Cancer
Malabaricone B, a naturally occurring plant phenolic, is an orally active *α-glucosidase* inhibitor with an IC₅₀ of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities .

HY-131114

Valiolamine	Glycosidase	Infection
Valiolamine, an aminocyclitol, is an *alpha-glucosidase* inhibitor. Valiolamine has potent alpha-glucosidase inhibitory activity against porcine intestinal sucrase, maltase and isomaltase. Valiolamine binds to porcine intestinal maltase and sucrase with K_i values of 350 nM and 30 nM, respectively .

HY-N16575

16-Oxoserratenediol	Glycosidase	Metabolic Disease
16-Oxoserratenediol (Compound 11) is a serratene-type triterpenoid found in Lycopodium cernuum L.. 16-Oxoserratenediol is a *α-glucosidase* inhibitor with inhibition rate of 43.93% at 100 μM. 16-Oxoserratenediol can be used for the research of diabetes .

HY-129131

Chrysin 6-C-arabinoside 8-C-glucoside	Glycosidase	Metabolic Disease
Chrysin 6-C-arabinoside 8-C-glucoside is a α±-glucosidase* inhibitors* which are widely used in the study for type 2 diabetes .

HY-N1218

Stellasterol	Glycosidase Bcl-2 Family	Others
Stellasterol is a natural product. Stellasterol has high affinity towards Bcl-2 protein (K_i: 118.05 nM). Stellasterol is a weak α-glucosidase inhibitor .

HY-N2223

Ganoderol B Ganodermadiol	Glycosidase	Metabolic Disease
Ganoderol B is a potent *α-glucosidase* inhibitor. Ganoderol B has high α-glucosidase inhibition with an IC₅₀ of 48.5 μg/mL (119.8 μM) .

HY-146128

Anti-hyperglycemic agent-1	Glycosidase	Metabolic Disease
Anti-hyperglycemic agent-1 (compound 10) is a potent *α-Glucosidase* inhibitor, with an IC₅₀ of 0.53 μM. Anti-hyperglycemic agent-1 can be used for diabetes research .

HY-152158

*α-Glucosidase-IN-22*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-22 (Compound 7i) is a *α-glucosidase* inhibitor with an IC₅₀ value of 0.64 μM. α-Glucosidase-IN-22 can be used for the research of type 2 diabetes .

HY-101399R

γ-Glu-Phe (Standard) H-γ-Glu-Phe-OH (Standard); γ-Glutamylphenylalanine (Standard)	Reference Standards Endogenous Metabolite	Others
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-U00090

N-Methylmoranoline MOR 14; N-Methyl-1-deoxynojirimycin; N-Methylmoranolin	Glycosidase	Metabolic Disease
N-Methylmoranoline (MOR 14) is an *α-glucosidase* inhibitor.

HY-N10426

(+)-Cembrene A	Glycosidase	Metabolic Disease
(+)-Cembrene A (Compound 5) is a *α-glucosidase* inhibitor with an IC₅₀ of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells .

HY-121991

N-5-Carboxypentyl-1-deoxynojirimycin	Glycosidase	Others
N-5-Carboxypentyl-1-deoxynojirimycin is an alpha-glucosidase inhibitor, and also can be used to prepare affinity matrices for binding to resins.

HY-146305

*α-Glucosidase-IN-4*	Glycosidase	Infection Cardiovascular Disease Others Neurological Disease Metabolic Disease Inflammation/Immunology Endocrinology Cancer
α-Glucosidase-IN-4 is a reversible and mixed type *α-glucosidase* inhibitor with an IC₅₀ of 12.98 μM, a K_I of 27.02 μM, and a K_IS of 13.65 μM, respectively .

HY-N7095

Ceftezole CTZ	Bacterial Antibiotic	Infection
Ceftezole (CTZ) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole (CTZ) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-N7763

Casuarictin	Glycosidase	Neurological Disease
Casuarictin is a potent and competitive *α-glucosidase* inhibitor with an IC₅₀ of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research .

HY-N8120

Bisabolone oxide A	Glycosidase	Metabolic Disease
Bisabolone oxide A is an *α-glucosidase* inhibitor .

HY-119593

α-Homonojirimycin Homonojirimycin	Glycosidase	Metabolic Disease
α-Homonojirimycin is a potent *α-glucosidase* inhibitor .

HY-N1901

(E)-p-Coumaramide	Glycosidase	Metabolic Disease
(E)-p-Coumaramide is an *α-Glucosidase* inhibitor that can be isolated from Welsh onion .

HY-U00266

Cefetrizole	Glycosidase	Infection Metabolic Disease
Ceftezole is an *α-Glucosidase* inhibitor with an IC₅₀ and a K_i of 2.1 μM and 0.578 μM, respectively.

HY-N12790

Arisanschinin D Ananonin B	Glycosidase	Metabolic Disease
Arisanschinin D (Ananonin B) is an *α-Glucosidase* inhibitor and can be isolated from Schisandra arisanensis Hay .

HY-146156

*α-Glucosidase-IN-7*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-7 is a noncompetitive *α-glucosidase* inhibitor with an IC₅₀ value of 18.9 µM .

HY-150960

*α-Glucosidase-IN-13*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-13 (Compound 8) is a *α-glucosidase* inhibitor with an IC₅₀ of 5.69 μM .

HY-134960

2,3-Indolobetulonic acid	Glycosidase	Metabolic Disease
2,3-Indolobetulonic acid (compound 2), a triterpenoid, is *α-glucosidase* inhibitor with an IC₅₀ of 1.8 µM .

HY-150959

*α-Glucosidase-IN-12*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-12 (compound 14) is a potent *α-glucosidase* inhibitor, with an IC₅₀ of 10.20 μM .

HY-150961

*α-Glucosidase-IN-14*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-14 (compound 5) is a potent *α-glucosidase* inhibitor, with an IC₅₀ of 5.22 μM .

HY-N9478

Sumaresinolic acid	Glycosidase	Others
Sumaresinolic acid (compound 6) is a natural product which can be extracted from heterophyllum root . Sumaresinolic acid is a alpha-glucosidase inhibitor .

HY-147879

*α-Glucosidase-IN-8*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-8 (Compound 4k) is a competitive *α-glucosidase* inhibitor with an IC₅₀ of 0.18 µg/mL .

HY-172758

*α-Glucosidase-IN-89*	Glycosidase	Others
α-Glucosidase-IN-89 (8g) is *α-glucosidase* inhibitor, with an IC₅₀ of 0.5 μM and a K_i of 0.46 µM .

HY-138992

2,3-Indolobetulin	Glycosidase Endogenous Metabolite	Others
2,3-Indolobetulin is a pentacyclic triterpene and a derivative of betulin. 2,3-Indolobetulin can be used in the synthesis of α-glucosidase inhibitors .

HY-162637

CTL26	Glycosidase	Metabolic Disease
CTL26 is a potent and orally active *α-glucosidase* inhibitor with an IC₅₀ value of 2.81 µM. CTL26 shows anti-diabetic efficacy .

HY-131504A

Valienamine	Glycosidase	Metabolic Disease
Valienamine is the *alpha-glucosidase* inhibitor. Valienamine is the key functional component of many natural glycosidase inhibitors including the crop protectant validamycin A and the antidiabetic agent acarbose .

HY-N12500

1'-O-Methyl neochebulinate	Glycosidase	Others
1'-O-Methyl neochebulinate, hydrolyzable tannin, is an α-glucosidase inhibitor with IC₅₀ value of 59.5 μM, isolated from the fruits of Terminalia chebula Retz .

HY-N4069

Lupinalbin A Boeravinone L	Estrogen Receptor/ERR Aryl Hydrocarbon Receptor Dipeptidyl Peptidase Glycosidase	Metabolic Disease
Lupinalbin A (Boeravinone L) is a dipeptidyl peptidase 4 (DPP4) and *α-glucosidase* inhibitor with IC₅₀ values of 45.2 and 53.4 µM, respectively. Lupinalbin A exhibits antidiabetic activity .

HY-N11512

*α-Glucosidase-IN-24*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-24 (Compound 13) is an *α-Glucosidase* inhibitor with an IC₅₀ of 451 μM. α-Glucosidase-IN-24 can be isolated from Swertia kouitchensis .

HY-149533

*α-Glucosidase-IN-34*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-34 (compound 7f) is a potent α-glucosidase inhibitor (IC₅₀: 2.90 μM) and can be used in the study of type 2 diabetes and hyperglycemia .

HY-169255

*sPLA2 inhibitor* 3**	Phospholipase Glycosidase	Metabolic Disease
sPLA2 inhibitor 3 (Compound 6c) is a potent *α-glucosidase* inhibitor (IC₅₀ = 0.0953 µM). sPLA2 inhibitor 3 can be used for the research of diabetes .

HY-115978

*α-Glucosidase-IN-2*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-2 (compound 5d) is a potent *α-Glucosidase* inhibitor with an IC₅₀ of 9.48 µM. α-Glucosidase-IN-2 is an antidiabetic agent .

HY-149532

*α-Glucosidase-IN-33*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-33 (compound 7c) is a potent α-glucosidase inhibitor (IC₅₀: 2.39 μM) and can be used in the study of type 2 diabetes and hyperglycemia .

HY-147823

*α-Glucosidase-IN-6*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-6 (compound 18) is a competitive *α-glucosidase* inhibitor with an IC₅₀ of 5.69 µM. α-Glucosidase-IN-6 has anti-diabetic potential .

HY-170866

*α-Glucosidase-IN-81*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-81 (Compound 5) is a potent *α-Glucosidase* inhibitor with an IC₅₀ value of 5.30 μM. α-Glucosidase-IN-81 is promising for research of diabetes .

HY-157488

*α-Glucosidase-IN-46*	Glycosidase	Metabolic Disease
α-Glucosidase-IN-46 is a potent *α-glucosidase* inhibitor with an IC₅₀ of 26.0 μM. α-Glucosidase-IN-46 can be used for the research of type 2 diabetes .

HY-N9075

9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one	Glycosidase	Cancer
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a phytoalexin and mixed competitive α-glucosidase inhibitor of Bacillus stearothermophilus (IC₅₀: 3.86 mg/L) .

Cat. No.	Product Name	Type

HY-78000

Methyl 4-formylbenzoate 4-Carbomethoxybenzaldehyde; 4-Carboxybenzaldehyde methyl ester; Terephthalaldehydic acid methyl ester; Methyl 4-formylbenzoate	Biochemical Assay Reagents
Methyl 4-formylbenzoate (4-Carbomethoxybenzaldehyde; 4-Carboxybenzaldehyde methyl ester; Terephthalaldehydic acid methyl ester; Methyl 4-formylbenzoate) is a intermediate that can be used for the synthesis of chalcone amide α-glucosidase inhibitors .

HY-78000R

Methyl 4-formylbenzoate (Standard) 4-Carbomethoxybenzaldehyde (Standard); 4-Carboxybenzaldehyde methyl ester (Standard); Terephthalaldehydic acid methyl ester (Standard); Methyl 4-formylbenzoate (Standard)	Biochemical Assay Reagents
Methyl 4-formylbenzoate (4-Carbomethoxybenzaldehyde) (Standard) is the analytical standard of Methyl 4-formylbenzoate (HY-78000). This product is intended for research and analytical applications. Methyl 4-formylbenzoate is a drug intermediate that can be used to synthesis chalcone amide α-glucosidase inhibitors .

Cat. No.	Product Name	Target	Research Area

HY-101399R

γ-Glu-Phe (Standard) H-γ-Glu-Phe-OH (Standard); γ-Glutamylphenylalanine (Standard)	Reference Standards Endogenous Metabolite	Others
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0089

Acarbose Maximum Cited Publications 10 Publications Verification BAY g 5421	Structural Classification Polysaccharides Microorganisms Classification of Application Fields Anti-aging Metabolic Disease Disease Research Fields Saccharides Source Classification	Glycosidase
Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active *alpha-glucosidase* inhibitor (IC₅₀=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-14860

1-Deoxynojirimycin 5+ Cited Publications Duvoglustat	Alkaloids Piperidine Alkaloids Classification of Application Fields Metabolic Disease Plants Moraceae Disease Research Fields Morus alba Linn. Source Classification	Glycosidase PI3K
1-Deoxynojirimycin (Duvoglustat) is a potent and orally active *α-glucosidase* inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features .

HY-14860A

1-Deoxynojirimycin hydrochloride 5+ Cited Publications Duvoglustat hydrochloride	Commelinaceae Classification of Application Fields Commelina communis L. Metabolic Disease Plants Disease Research Fields Saccharides Monosaccharides Source Classification	Glycosidase PI3K Bacterial Antibiotic
1-Deoxynojirimycin hydrochloride (Duvoglustat hydrochloride) is a potent and orally active *α-glucosidase* inhibitor. 1-Deoxynojirimycin hydrochloride suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin hydrochloride possesses antihyperglycemic, anti-obesity, and antiviral features .

HY-B0025

Voglibose 1 Publications Verification	Structural Classification Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Saccharides Source Classification	Glycosidase
Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis .

HY-N0419

Quercimeritrin 2 Publications Verification Quercetin-7-O-β-D-glucopyranoside	Flavonols Structural Classification Ginkgoaceae Classification of Application Fields Metabolic Disease Plants Compositae Endogenous metabolite Ginkgo biloba Human Gut Microbiota Metabolites Flavonoids Derris scandens Disease Research Fields Source Classification	Glycosidase c-Kit MMP VEGFR Aurora Kinase
Quercimeritrin (Quercetin-7-O-β-D-glucopyranoside) is an orally active *α-glucosidase* inhibitor (with an IC₅₀ of 79.88 μM against the Saccharomyces cerevisiae enzyme) and a P-gp substrate, with anti-angiogenic and antioxidant activities. Quercimeritrin does not cross the blood-brain barrier and does not inhibit cytochrome P450 enzymes. Quercimeritrin precisely binds to and inhibits the active sites of c-Kit, MMP-2, Aurora-A kinases and α-glucosidase, thereby disrupting target functions. Quercimeritrin effectively regulates postprandial blood glucose and also exhibits significant anti-angiogenic activity, which inhibits endothelial cell proliferation and microvascular growth. Quercimeritrin can be used in the research of diabetes and breast cancer .

HY-N6675

Gardenia yellow	Structural Classification Natural Products Neurological Disease Classification of Application Fields Lridaceae Plants Crocus sativus L. Disease Research Fields Source Classification Cancer	Amylases Glycosidase
Gardenia yellow is a competitive inhibitor of *α-Amylase* (HY-B2193) and *α-glucosidase. Gardenia yellow can bind to the catalytic sites of α-Amylase* and α-glucosidase, inhibit starch digestion, and significantly increase the contents of resistant starch and slowly digestible starch in starch-based systems. Gardenia yellow reduces the glycemic index and hydrolysis index. Gardenia yellow can be used in diabetes-related research .

HY-125713

Ganoderic acid Y	Infection Triterpenes Classification of Application Fields Terpenoids Polyporaceae Plants Disease Research Fields Source Classification	Glycosidase Enterovirus
Ganoderic acid Y is a *α-glucosidase* inhibitor with an IC₅₀ of 170 μM for yeast α-glucosidase. Ganoderic acid Y inhibits enterovirus 71 (EV71) replication through blocking EV71 uncoating .

HY-W009417

Cedryl acetate	Structural Classification Classification of Application Fields Terpenoids Sesquiterpenes Taxodiaceae Metabolic Disease Plants Cunninghamia lanceolata var. konishii Disease Research Fields Source Classification	Environmental Pollutants Glycosidase
Cedryl acetate is an orally active *α-glucosidase* inhibitor with an IC₅₀ of 94 μM against yeast α-glucosidase. Cedryl acetate reduces high-fat diet-induced body weight gain, visceral fat pad weight, adipocyte hypertrophy, hepatic lipid accumulation, glucose intolerance, insulin resistance and gluconeogenesis. Cedryl acetate can be used in the research of obesity and obesity-related metabolic syndrome .

HY-N2168

Pinoresinol 4-O-β-D-glucopyranoside 1 Publications Verification (+)-Pinoresinol 4-O-β-D-glucopyranoside	Cardiovascular Disease Monophenols other families Classification of Application Fields Lignans Phenols Phenylpropanoids Plants Disease Research Fields Source Classification	Glycosidase Estrogen Receptor/ERR Phosphodiesterase (PDE)
Pinoresinol 4-O-β-D-glucopyranoside ((+)-Pinoresinol 4-O-β-D-glucopyranoside) is an orally active *α-glucosidase* inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

HY-N7377

Butyl isobutyl phthalate	Natural Products other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Source Classification	Glycosidase
Butyl isobutyl phthalate is isolated from the rhizoid of Laminaria japonica. Butyl isobutyl phthalate is a non-competitive *α-glucosidase* inhibitor with an IC₅₀ value of 38 μM. Butyl isobutyl phthalate shows a hypoglycemic effect and has the potential for diabetes treatment .

HY-B0089R

Acarbose (Standard) BAY g 5421 (Standard)	Structural Classification Polysaccharides Microorganisms Saccharides Source Classification	Reference Standards Glycosidase
Acarbose (Standard) is the analytical standard of Acarbose. This product is intended for research and analytical applications. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active alpha-glucosidase inhibitor (IC50=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-14860R

1-Deoxynojirimycin (Standard) Duvoglustat (Standard)	Alkaloids Piperidine Alkaloids Structural Classification Plants Moraceae Morus alba Linn. Source Classification	Reference Standards Glycosidase PI3K
1-Deoxynojirimycin (Standard) is the analytical standard of 1-Deoxynojirimycin. This product is intended for research and analytical applications. 1-Deoxynojirimycin (Duvoglustat) is a potent and orally active α-glucosidase inhibitor. 1-Deoxynojirimycin suppresses postprandial blood glucose and is widely used for diabetes mellitus. 1-Deoxynojirimycin possesses antihyperglycemic, anti-obesity, and antiviral features .

HY-N7683

Prunetin 5-O-β-D-glucopyranoside	Structural Classification Monophenols Flavonoids Classification of Application Fields Rosaceae Phenols Metabolic Disease Plants Prunus avium Disease Research Fields Isoflavones Source Classification	Glycosidase
Prunetin 5-O-β-D-glucopyranoside is an isoflavone. Prunetin 5-O-β-D-glucopyranoside can be isolated from the pedicels of Prunus avium and Prunus cerasus. Prunetin 5-O-β-D-glucopyranoside acts as a non-competitive *α-glucosidase* inhibitor, with a IC₅₀ of 56.05 μg/mL and a K_i of 121 μg/mL against Saccharomyces cerevisiae α-glucosidase. Prunetin 5-O-β-D-glucopyranoside can be used in studies related to type 2 diabetes .

HY-N0946

(-)-Pinoresinol 4-O-glucoside (-)-Pinoresinol 4-O-β-D-glucopyranoside	Cicer arietinum L. Plants Compositae Saccharides Monosaccharides Source Classification	Glycosidase
(-)-Pinoresinol 4-O-glucoside ((-)-Pinoresinol 4-O-β-D-glucopyranoside) is a potent and orally active *α-glucosidase* inhibitor with an IC₅₀ value of 48.13 µM. (-)-Pinoresinol 4-O-glucoside increases cell migration and early differentiation of pre-osteoblasts. (-)-Pinoresinol 4-O-glucoside increases protein level of BMP2, p-Smad1/5/8, RUNX2. (-)-Pinoresinol 4-O-glucoside attenuates oxidative stress, hyperglycemia and hepatic toxicity. (-)-Pinoresinol 4-O-glucoside has the potential for the research of osteoporosis and periodontal disease .

HY-N8517

Malabaricone B	Infection Classification of Application Fields Ketones, Aldehydes, Acids Phenols Polyphenols Metabolic Disease Myristicaceae Plants Myristica fragrans Houtt. Disease Research Fields Cancer Source Classification	Glycosidase Apoptosis
Malabaricone B, a naturally occurring plant phenolic, is an orally active *α-glucosidase* inhibitor with an IC₅₀ of 63.7 µM. Malabaricone B has anticancer, antimicrobial, anti-oxidation and antidiabetic activities .

HY-N16575

16-Oxoserratenediol	Lycopodiaceae Triterpenes Structural Classification Terpenoids Palhinhaea cernua (L.) Vasc. et Franco Plants Source Classification	Glycosidase
16-Oxoserratenediol (Compound 11) is a serratene-type triterpenoid found in Lycopodium cernuum L.. 16-Oxoserratenediol is a *α-glucosidase* inhibitor with inhibition rate of 43.93% at 100 μM. 16-Oxoserratenediol can be used for the research of diabetes .

HY-126535

Magnoloside B	Magnolia officinalis. Rehd. et Wils. Magnoliaceae Phenols Polyphenols Plants Source Classification	Glycosidase
Magnoloside B is an *α-glucosidase* inhibitor (IC₅₀=0.69 mM), which can be obtained from Magnolia officinalis stem bark. Magnoloside B shows moderate inhibitory activity against MGC-803 and HepG2 cells. Magnoloside B has the potential to study cancer and diabetes .

HY-129131

Chrysin 6-C-arabinoside 8-C-glucoside	Flavonoids Rheum palmatum L. Flavones Polygonaceae Plants Source Classification	Glycosidase
Chrysin 6-C-arabinoside 8-C-glucoside is a α±-glucosidase* inhibitors* which are widely used in the study for type 2 diabetes .

HY-N1218

Stellasterol	Structural Classification Animals Steroids Source Classification	Glycosidase Bcl-2 Family
Stellasterol is a natural product. Stellasterol has high affinity towards Bcl-2 protein (K_i: 118.05 nM). Stellasterol is a weak α-glucosidase inhibitor .

HY-N2223

Ganoderol B Ganodermadiol	Triterpenes Classification of Application Fields Terpenoids Polyporaceae Metabolic Disease Ganoderma lucidum (Leyss. Ex Fr.) Karst. Plants Disease Research Fields Source Classification	Glycosidase
Ganoderol B is a potent *α-glucosidase* inhibitor. Ganoderol B has high α-glucosidase inhibition with an IC₅₀ of 48.5 μg/mL (119.8 μM) .

HY-101399R

γ-Glu-Phe (Standard) H-γ-Glu-Phe-OH (Standard); γ-Glutamylphenylalanine (Standard)	Structural Classification Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Ceftezole (sodium) (Standard) is the analytical standard of Ceftezole (sodium). This product is intended for research and analytical applications. Ceftezole sodium (CTZ sodium) is a broad-spectrum cephem antibiotic against many species of gram-positive and gram-negative bacteria. Ceftezole sodium (CTZ sodium) is an alpha-glucosidase inhibitor with in vivo anti-diabetic activity .

HY-N10426

(+)-Cembrene A	Structural Classification Animals Terpenoids Source Classification	Glycosidase
(+)-Cembrene A (Compound 5) is a *α-glucosidase* inhibitor with an IC₅₀ of 30.31 μM. (+)-Cembrene A is nontoxic towards human normal hepatocyte (LO2) cells .

HY-N7763

Casuarictin	Lythraceae Trapa natans L. Phenols Polyphenols Plants Source Classification	Glycosidase
Casuarictin is a potent and competitive *α-glucosidase* inhibitor with an IC₅₀ of 0.21 μg/mL. Casuarictin is a presenilin stabilization factor like protein (PSFL) protein inhibitor. Casuarictin can be used for Alzheimer's disease research .

HY-N11728

2,7"-Phloroglucinol-6,6'-bieckol	Microorganisms Phenols Polyphenols Source Classification	Amylases Glycosidase
2,7"-Phloroglucinol-6,6'-bieckol is an orally active dual *α-amylase/α-glucosidase* inhibitor with IC₅₀ values of 6.94 μM and 23.35 μM respectively. 2,7"-Phloroglucinol-6, 6'-bieckol alleviates postprandial hyperglycemia in diabetic mice. 2,7"-Phloroglucinol-6,6'-bieckol can be used in diabetes research .

HY-N8120

Bisabolone oxide A	Natural Products other families Classification of Application Fields Metabolic Disease Plants Disease Research Fields Source Classification	Glycosidase
Bisabolone oxide A is an *α-glucosidase* inhibitor .

HY-119593

α-Homonojirimycin Homonojirimycin	Natural Products Omphalea diandra Vell. Euphorbiaceae Plants Source Classification	Glycosidase
α-Homonojirimycin is a potent *α-glucosidase* inhibitor .

HY-N1901

(E)-p-Coumaramide	Monophenols Portulacaceae Allium fistulosum L. Phenols Portulaca oleracea Linn. Plants Amaryllidaceae Source Classification	Glycosidase
(E)-p-Coumaramide is an *α-Glucosidase* inhibitor that can be isolated from Welsh onion .

HY-N12790

Arisanschinin D Ananonin B	Lignans Schisandra arisanensis Hayata Ic. Phenylpropanoids Plants Schisandraceae Source Classification	Glycosidase
Arisanschinin D (Ananonin B) is an *α-Glucosidase* inhibitor and can be isolated from Schisandra arisanensis Hay .

HY-N9478

Sumaresinolic acid	Malvaceae Pterospermum heterophyllum Hance Plants Source Classification	Glycosidase
Sumaresinolic acid (compound 6) is a natural product which can be extracted from heterophyllum root . Sumaresinolic acid is a alpha-glucosidase inhibitor .

HY-N12500

1'-O-Methyl neochebulinate	Combretaceae Phenols Polyphenols Terminalia chebula Retz. Plants Source Classification	Glycosidase
1'-O-Methyl neochebulinate, hydrolyzable tannin, is an α-glucosidase inhibitor with IC₅₀ value of 59.5 μM, isolated from the fruits of Terminalia chebula Retz .

HY-N4069

Lupinalbin A Boeravinone L	Flavonoids Leguminosae Plants Other Flavonoids Lupinus albus Linn. Source Classification	Estrogen Receptor/ERR Aryl Hydrocarbon Receptor Dipeptidyl Peptidase Glycosidase
Lupinalbin A (Boeravinone L) is a dipeptidyl peptidase 4 (DPP4) and *α-glucosidase* inhibitor with IC₅₀ values of 45.2 and 53.4 µM, respectively. Lupinalbin A exhibits antidiabetic activity .

HY-N11512

*α-Glucosidase-IN-24*	Structural Classification Xanthones Gentianaceae Phenols Plants Swertia kouitchensis Franch. Source Classification	Glycosidase
α-Glucosidase-IN-24 (Compound 13) is an *α-Glucosidase* inhibitor with an IC₅₀ of 451 μM. α-Glucosidase-IN-24 can be isolated from Swertia kouitchensis .

HY-N9075

9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one	Monophenols Phenols Musaceae Plants Musa basjoo Sieb. et Zucc. Source Classification	Glycosidase
9-(4′-Hydroxyphenyl)-2-methoxyphenalen-1-one is a phytoalexin and mixed competitive α-glucosidase inhibitor of Bacillus stearothermophilus (IC₅₀: 3.86 mg/L) .

HY-B0089A

Acarbose sulfate Bay-g 5421 sulfate	Polysaccharides Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Saccharides Source Classification	Glycosidase
Acarbose (BAY g 5421) sulfate, antihyperglycemic agent, is an orally active *alpha-glucosidase* inhibitor (IC₅₀=11 nM). Acarbose sulfate can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-N12664

*α-Glucosidase-IN-54*	Ketones, Aldehydes, Acids Myrtaceae Plants Syzygium jambos (L.) Alston Source Classification	Glycosidase
α-Glucosidase-IN-54 (compound 2) is a *α-glucosidase* inhibitor with the IC₅₀ of 0.011 mM, and can be isolated form Syzygium jambos (L.). α-Glucosidase-IN-54 can be used for study of diabetes .

HY-N12689

*α-Glucosidase-IN-56*	Pistacia chinensis Bunge Phenols Polyphenols Plants Anacardiaceae Source Classification	Glycosidase
α-Glucosidase-IN-56 (compound 1) is an orally active, potent *α‐glucosidase* inhibitor with an IC₅₀ value of 45.86 μM. α-Glucosidase-IN-56 has potent anti-glycation activities .

HY-N13188

2'-Rhamnoechinacoside Michelioside A	Magnoliaceae Phenols Polyphenols Plants Michelia yunnanensis Franch. ex Finet & Gagnep. Source Classification	Glycosidase
2'-Rhamnoechinacoside (Michelioside A), a compound of phenylethanoid glycosides, is a *α-glucosidase* inhibitor with anti-tumor activity, which is derived from Phlomis stewartii. 2'-Rhamnoechinacoside can be used for research of UV-absorbing and cancers .

HY-162541

*α-Glucosidase-IN-64*	Natural Products Hypericaceae Hypericum beanii N. Robson Plants Source Classification	Glycosidase
α-Glucosidase-IN-64 (compound 10) is a potent *α-glucosidase* inhibitor with an IC₅₀ value of 8.62 µM. α-Glucosidase-IN-64 is a polycyclic polyprenylated acylphloroglucinol that can be isolated from hypericum beanii .

HY-N12006

6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone	Quinones Anthraquinones Caesalpiniaceae Cassia obtusifolia (L.) H. S. Irwin & Barneby Plants Source Classification	Glycosidase
6,8-Dihydroxy-1,2,7-trimethoxy-3-methylanthraquinone (compound 1) is an anthraquinone α-glucosidase inhibitor (IC₅₀:185 μM), which can be isolated from Cassia seeds .

HY-N13173

*α-Glucosidase-IN-70*	Quinones Anthraquinones Gentianaceae Swertia mussotii Franch. Plants Source Classification	Glycosidase
α-Glucosidase-IN-70 (compound 9) is an α-glucosidase inhibitor (IC₅₀=31.1 μM) isolated from the traditional Chinese herbal medicine Swertia mussotii. α-Glucosidase-IN-70 can be used in the research of diabetes .

HY-N15138

Sativanone	Flavonoids Dalbergia tonkinensis Prain Leguminosae Isoflavanones Plants Source Classification	Glycosidase
Sativanone is a compound that can be isolated from Dalbergia tonkinensis. Sativanone is a potent *α-glucosidase* inhibitor, with an EC₅₀ of 0.357 mg/mL for rat α-glucosidase. Sativanone has antibacterial activity against Ralstonia solanacearum. Sativanone also has anti-senescent and antioxidant effects .

HY-N12761

Penpaxilloids A	Terpenoids Marine natural products Diterpenoids Marine microorganism Source Classification	Phosphatase Glycosidase
Penpaxilloids A (Compound 1) is a non-competitive inhibitor of protein tyrosine phosphatase 1B (PTP1B) with an IC₅₀ value of 8.60 μM. Penpaxilloids A can be isolated from the fungus Penicillium sp. ZYX-Z-143. Penpaxilloids A is also an α-glucosidase (α-glucosidase) inhibitor with anti-inflammatory activity .

HY-N10440

3-Oxo-hop-22(29)-ene	Cnidoscolus spinosus Lundell Triterpenes Terpenoids Euphorbiaceae Plants Source Classification	Glycosidase
3-Oxo-hop-22(29)-ene is a yeast α-glucosidase inhibitor. 3-Oxo-hop-22(29)-ene shows a moderate effect on the viability of T. cruzi and L. mexicana. 3-Oxo-hop-22(29)-ene shows marginal activity of anti-inflammatory .

HY-N7170

(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid	Ketones, Aldehydes, Acids Verbenaceae Duranta erecta L. Plants Source Classification	Glycosidase
(-)-6β-Hydroxy-5β,8β,9β,10α-cleroda-3,13-dien-16,15-olid-18-oic acid (compound 4) is a *α-Glucosidase* inhibitor with an IC₅₀ value of 577.7 µM .

HY-N15602

Isosojagol	Natural Products Leguminosae Plants Dolichos trilobus Houtt. Source Classification	Glycosidase NO Synthase
Isosojagol (Compound 5) is a *α-Glucosidase* inhibitor with an IC₅₀ of 32.2  μM. Isosojagol can be isolated from the Roots of Dolichos trilobus. Isosojagol has anti-inflammatory activity and inhibits LPS (HY-D1056A1)-induced NO production in RAW264.7 cells. Isosojagol can be used for fracture, soft tissue injuries and rheumatoid arthritis research .

HY-B0025R

Voglibose (Standard)	Structural Classification Microorganisms Saccharides Source Classification	Reference Standards Glycosidase
Voglibose (Standard) is the analytical standard of Voglibose. This product is intended for research and analytical applications. Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis[1].

HY-W009417R

Cedryl acetate (Standard)	Structural Classification Natural Products Taxodiaceae Plants Cunninghamia lanceolata var. konishii Source Classification	Reference Standards Glycosidase Environmental Pollutants
Cedryl acetate (Standard) is the analytical standard of Cedryl acetate. This product is intended for research and analytical applications. Cedryl acetate is an orally active *α-glucosidase* inhibitor with an IC₅₀ of 94 μM against yeast α-glucosidase. Cedryl acetate reduces high-fat diet-induced body weight gain, visceral fat pad weight, adipocyte hypertrophy, hepatic lipid accumulation, glucose intolerance, insulin resistance and gluconeogenesis. Cedryl acetate can be used in the research of obesity and obesity-related metabolic syndrome .

HY-N2168R

Pinoresinol 4-O-β-D-glucopyranoside (Standard) (+)-Pinoresinol 4-O-β-D-glucopyranoside (Standard)	Structural Classification Monophenols other families Lignans Phenols Phenylpropanoids Plants Source Classification	Glycosidase Reference Standards Estrogen Receptor/ERR Phosphodiesterase (PDE)
Pinoresinol 4-O-β-D-glucopyranoside (Standard) is the analytical standard of Pinoresinol 4-O-β-D-glucopyranoside (HY-N2168). This product is intended for research and analytical applications. Pinoresinol 4-O-β-D-glucopyranoside is an orally active *α-glucosidase* inhibitor, with an IC₅₀ of 48.13 μg/mL. Pinoresinol 4-O-β-D-glucopyranoside binds to estrogen receptors. Pinoresinol 4-O-β-D-glucopyranoside inhibits phosphodiesterase. Pinoresinol 4-O-β-D-glucopyranoside exhibits various activities such as antioxidant, anti-inflammatory, anti-hyperglycemic, hepatoprotective and anti-epileptic effects .

HY-N18381

Deacylhericene	Structural Classification Microorganisms Simple Phenylpropanols Phenylpropanoids Source Classification	Glycosidase
Deacylhericene is an *α-glucosidase* inhibitor with an IC₅₀ of 12.5 μM. Deacylhericene functionally inhibits the activity of α-glucosidase .

HY-N17553

N-Formyldehydroanonaine	Structural Classification Natural Products Sabiaceae Blume Sabia parvifloraWall. ex Roxb. Plants Source Classification	Glycosidase
N-Formyldehydroanonaine is a potent *α-glucosidase* inhibitor with an IC₅₀ of 104.6 μM against yeast α-glucosidase. N-Formyldehydroanonaine can be used for the research of diabetes mellitus .

Cat. No.	Product Name	Chemical Structure

HY-B0089S

Acarbose-d4
Acarbose-d₄ (BAY g 5421-d₄) is deuterium labeled Acarbose. Acarbose (BAY g 5421), antihyperglycemic agent, is an orally active *alpha-glucosidase* inhibitor (IC₅₀=11 nM). Acarbose can potentiate the hypoglycemic effects of sulfonylureas or insulin .

HY-W749516

Voglibose-13C3

Voglibose- ¹³C₃ is the ¹³C-labeled Voglibose (HY-B0025). Voglibose is an orally active alpha-glucosidase inhibitor that prevents the development of colorectal precancerous lesions induced by obesity and diabetes. Voglibose reduces oxidative stress in an inflammatory environment and inhibits the insulin-like growth factor/insulin-like growth factor-1 receptor (IGF/IGF-1R) functional axis.

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