2. Metabolic Enzyme/Protease
  3. Glycosidase
  4. LY-23

LY-23 is an orally active α-glucosidase inhibitor (Ki = 0.05 μM), with IC50 values of 0.18 μM, 0.14 μM and 0.51 μM against maltase, sucrase and isomaltase, respectively. LY-23 reduces the level of postprandial blood glucose elevation. LY-23 is applicable to research related to postprandial hyperglycemia.

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LY-23

LY-23 Chemical Structure

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LY-23 Related Antibodies

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Description

LY-23 is an orally active α-glucosidase inhibitor (Ki = 0.05 μM), with IC50 values of 0.18 μM, 0.14 μM and 0.51 μM against maltase, sucrase and isomaltase, respectively. LY-23 reduces the level of postprandial blood glucose elevation. LY-23 is applicable to research related to postprandial hyperglycemia[1].

In Vitro

LY-23 (72 h) exhibits no significant in vitro cytotoxicity in HEK-293T and L02 cells at concentrations up to 400 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LY-23 Related Antibodies
In Vivo

LY-23 (1.0 mg/kg; p.o.; single administration) reduces postprandial blood glucose in maltose-loaded mice, with a 47.1% decrease in its AUC0-t[1].
LY-23 (1.0-10.0 mg/kg; p.o.; single administration) reduces postprandial blood glucose in sucrose-loaded mice. At the dose of 1.0 mg/kg, it decreases AUC0-t by 41.5%, while at 10.0 mg/kg, the reduction rate of AUC0-t reaches 48.1%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice (male, SPF grade, 22-26 g)[1]
Dosage: 1.0 mg/kg
Administration: p.o.; single dose
Result: Reduced blood glucose levels by 54.3% at 15 minutes.
Reduced blood glucose levels by 58.1% at 30 minutes.
Reduced blood glucose levels by 44.3% at 60 minutes.
Reduced the area under the blood glucose curve (AUC) by 47.1% compared to the control group.
Animal Model: ICR mice (male, SPF grade, 22-26 g)[1]
Dosage: 1.0 mg/kg; 10.0 mg/kg
Administration: p.o.; single dose
Result: Reduced blood glucose levels by 57.5% at 15 minutes, 53.3% at 30 minutes, 34.3% at 60 minutes, and reduced the AUC by 41.5% compared to the control group (1.0 mg/kg).
Reduced blood glucose levels by 57.0% at 15 minutes, 56.4% at 30 minutes, 47.0% at 60 minutes, and reduced the AUC by 48.1% compared to the control group (10.0 mg/kg).
Molecular Weight

505.84

Formula

C19H27Cl3O7S
SMILES

OC[C@@H]1[C@@H](O)[C@H](O)C[S@+]1C[C@H]([C@H]2O[C@H](C)[C@H](OCC3=CC(Cl)=CC=C3Cl)[C@H]2O)O.[Cl-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LY-23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LY-23LY23LY 23Glycosidaseisomaltasepostprandial glucose elevationmale ICR micesucraseL02 cellsHEK-293T cellspostprandial hyperglycemiaaromatic amino acid residueyeast α-glucosidasemaltaseInhibitorinhibitorinhibit

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