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Protein cross-linker

" in MedChemExpress (MCE) Product Catalog:

標的別:	DNA Alkylator/Crosslinker (8) ADC Linker (3) Amino Acid Derivatives (3) Antibiotic (7) Apoptosis (5) Bacterial (8) Bcl-2 Family (1) Beta-lactamase (3) Biochemical Assay Reagents (70) Caspase (1) Drug-Linker Conjugates for ADC (1) E3 Ligase Ligand-Linker Conjugates (1) EAAT (1) Endogenous Metabolite (5) Environmental Pollutants (1) Epigenetic Reader Domain (1) Eukaryotic Initiation Factor (eIF) (1) Fluorescent Dye (5) Fructose-1,6-bisphosphate aldolase (1) Glutaminase (1) Glycosidase (2) Isotope-Labeled Compounds (5) MOFs (2) Monoamine Oxidase (1) Penicillin-binding protein (PBP) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (7) Ser/Thr Protease (1) Topoisomerase (1)
研究分野別:	Cancer (19) Cardiovascular Disease (4) Infection (9) Inflammation/Immunology (11) Metabolic Disease (8) Neurological Disease (6)
クリックケミストリー:	Azide (4) BCN (1) Alkynes (1)

112

阻害剤およびアゴニスト

スクリーニングライブラリ

蛍光色素

生化学アッセイ試薬

ペプチド

MCE キット

阻害性抗体

天然物

同位体標識化合物

クリックケミストリー

Targets Recommended: DNA Alkylator/Crosslinker

製品番号	製品名	Target	研究分野	構造式

HY-W019543

Disuccinimidyl suberate Crosslinker 10+ Cited Publications	Biochemical Assay Reagents	Cancer
Disuccinimidyl suberate Crosslinker is an amine-reactive bifunctional protein crosslinker. Disuccinimidyl suberate Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-B0245

Busulfan Maximum Cited Publications 19 Publications Verification	DNA Alkylator/Crosslinker Apoptosis	Infection Neurological Disease Inflammation/Immunology Cancer
Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-114697

DSG Crosslinker 4 Publications Verification Disuccinimidyl glutarate	Biochemical Assay Reagents	Inflammation/Immunology
DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-124329

BS3 Crosslinker 1 Publications Verification	Biochemical Assay Reagents	Cancer
BS3 Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-118759

DSP Crosslinker 2 Publications Verification	Biochemical Assay Reagents	Inflammation/Immunology
DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-42360

SMCC 1 Publications Verification	ADC Linker	Cancer
SMCC is a protein crosslinker. SMCC contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses .

HY-124329A

BS3 Crosslinker disodium 1 Publications Verification	Biochemical Assay Reagents	Cancer
BS3 Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-137383

Sulfo-SANPAH	Biochemical Assay Reagents Reactive Oxygen Species (ROS)	Others
Sulfo-SANPAH is a primary amine-nitrobenzene azide cross-linker. Sulfo-SANPAH improves the functionalization process of PDMS surfaces, is covalently bound to the PAAm gel surface. Sulfo-SANPAH is widely used to crosslink ECM proteins to various substrates, including acrylic-based hydrogels, such as polyacrylamide hydrogels. Sulfo-SANPAH facilitates covalent binding through its negatively charged sulfonate group on its N-hydroxysuccinimide ester ring and a photoactivated phenyl azide group that is highly reactive with nucleophiles and free radicals .

HY-W074785

Carboxyl diazirine alkyne	Biochemical Assay Reagents	Others
Carboxyl diazirine alkyne is a protein cross-linking compound. Carboxyl diazirine alkyne plays a crucial role in the research on the inhibition and labeling of FTO protein by fluorescein derivatives .

HY-W035129

endo-BCN-NHS carbonate	Biochemical Assay Reagents	Others
endo-BCN-NHS carbonate is an elastin-like protein (ELP) modification reagent. endo-BCN-NHS carbonate can react with lysine residues in ELP to make ELP carry BCN groups, and then cross-link ELP through strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. endo-BCN-NHS carbonate promotes hydrogel formation. endo-BCN-NHS carbonate is mainly used in cell encapsulation related research .

HY-157414

Azide-A-DSBSO crosslinker	Biochemical Assay Reagents	Others
Azide-A-DSBSO crosslinker is a mass spectrometry (MS) cleavable, membrane permeable, homobifunctional, azide-labeled, acid-cleavable crosslinking peptide. Azide-A-DSBSO crosslinker crosslinks proteins via NHS ester reaction with lysine residues. Azide-A-DSBSO crosslinker can be used to study protein-protein interactions by cross-linking mass spectrometry (XL-MS) ^{[1] .}

HY-129380

Fructosyl-lysine 1 Publications Verification Fructoselysine	Endogenous Metabolite	Metabolic Disease
Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes?detection .

HY-123740

Disuccinimidyl sulfoxide DSSO	Biochemical Assay Reagents	Others
Disuccinimidyl sulfoxide (DSSO) is a sulfoxide-containing crosslinker targeting amino groups that can be cleaved by MS, and it is suitable for model peptides, proteins, and multisubunit protein complexes. Disuccinimidyl sulfoxide contains two symmetric collision-induced dissociation (CID)-cleavable sites, enabling the identification of DSSO-crosslinked peptides based on different fragmentation patterns .

HY-W123005

Dimethyl pimelimidate dihydrochloride 1 Publications Verification	Biochemical Assay Reagents	Others
Dimethyl pimelimidate dihydrochloride is a bifunctional imidoester protein-protein crosslinker used in chromatin immunoprecipitation (ChIP) assays .

HY-13588

Cefsulodin sodium SCE-129 sodium	Bacterial Antibiotic	Infection
Cefsulodin (SCE-129) sodium is a third generation β lactam antibiotic and member of the cephems subgroup of antibiotics. Cefsulodin sodium inhibits cell wall synthesis by competitively inhibiting penicillin binding protein (PBP) cross-linking and transpeptidation of peptidogly. Cefsulodin sodium is a potent tyrosine phosphatase inhibitor against mPTPB, a virulent phosphatase from Mycobacterium tuberculosis, with an IC₅₀ value of 16 μM .

HY-111434A

N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride UAA crosslinker 1 hydrochloride	Amino Acid Derivatives	Cancer
N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride (UAA crosslinker 1 hydrochloride) is a click chemistry-reactive amino acid derivative. N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride mediates the generation of antibody-drug conjugates (ADCs). N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride is used for site-specific incorporation into recombinant proteins, or for synthesizing chemical probes and tools for biological research .

HY-148140

Cross-linked dextran G 25 1 Publications Verification	Biochemical Assay Reagents	Others
Cross-linked dextran G 25 is a dextran chromatography medium. Cross-linked dextran G 25 separates from 1 to 5 kD (spherical proteins) and can be used for the separation of peptides as well as for the desalting and buffer replacement of large molecule proteins .

HY-W332335

Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium	Biochemical Assay Reagents	Others
Sulfosuccinimidyl-6-(biotinamido)hexanoate sodium is a protein crosslinker, and is a biotinylation reagentcan for labeling cell surface proteins .

HY-148139

Cross-linked dextran G 75	Biochemical Assay Reagents	Others
Cross-linked dextran G 75 is a Gel-filtration media. Cross-linked dextran G 75 also is a dextran-based matrix and used for Gel-filtration chromatography (Particle size range: 40-120 μm; Sphere protein separation range: 3K-80K Da; Polysaccharide separation range: 1K-50K Da) .

HY-W041994

GMBS	Fructose-1,6-bisphosphate aldolase Biochemical Assay Reagents	Cancer
GMBS is a heterobifunctional crosslinker targeting primary amines and sulfhydryl groups. GMBS can be used for chemical crosslinking of proteins and crosslinking mass spectrometry (CXMS) to study protein folding and map interfaces between interacting proteins .

HY-141452

Propanedial (13.88 mM in water) Malondialdehyde	Endogenous Metabolite	Neurological Disease
Propanedial (Malondialdehyde) (13.88 mM in water) is one of the final products of lipid peroxidation. Propanedial causes protein inactivation, DNA damage and cross-linking by forming stable covalent adducts with biological macromolecules, which is the main mechanism for its cytotoxicity and genotoxicity. Propanedial production increases with the elevation of free radicals. Propanedial is a key biomarker for evaluating the level of cellular oxidative stress ^[1][2][3].

HY-N1470

Plantagoside	Glycosidase	Metabolic Disease
Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .

HY-B1275

Cephalothin sodium 3 Publications Verification Cefalotin sodium	Beta-lactamase Bacterial Antibiotic	Infection
Cephalothin (Cephalotin) sodium is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an K_i of 0.32 µM. Cephalothin sodium binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin sodium shows antibacterial activity against a variety of bacteria. Cephalothin sodium can be used in hematological and nephrotoxicity studies .

HY-B1275A

Cephalothin 3 Publications Verification Cephalotin	Beta-lactamase Bacterial Antibiotic	Infection Cardiovascular Disease
Cephalothin (Cephalotin) is a semi-synthetic cephalosporin antibiotic and beta-lactam antibiotic. Cephalothin inhibits class C β-lactamase AmpC, with an K_i of 0.32 µM. Cephalothin binds to penicillin-binding proteins, interfering with the cross-linking of peptidoglycan in the cell wall and thus hindering the normal synthesis of the bacterial cell wall. Cephalothin shows antibacterial activity against a variety of bacteria. Cephalothin can be used in hematological and nephrotoxicity studies .

HY-174892

Biotin-PEG5-NHS ester	Biochemical Assay Reagents	Others
Biotin-PEG5-NHS ester is a heterobifunctional crosslinker as well as a polyethylene glycol-containing bioconjugation reagent. Biotin-PEG5-NHS ester is widely used in scientific research fields such as the construction of highly sensitive biosensors, the development of targeted drug delivery systems (e.g., liposome modification), immunofluorescence imaging, and protein affinity purification, and serves as an important tool for achieving precise labeling and functionalization of biomolecules .

HY-138560

Cross-linked dextran G 50 2 Publications Verification	Biochemical Assay Reagents	Others
Cross-linked dextran G 50 is a gel filtration medium. Cross-linked dextran G 50 can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da) .

HY-107783

Sulfo-GMBS	Biochemical Assay Reagents	Others
Sulfo-GMBS is a crosslinker widely used in chemical modification and coupling reactions of proteins and peptides. Among amine-thiol crosslinkers, Sulfo-GMBS generates the largest number of crosslinks and covers most of the crosslinks identified by AMAS and GMBS .

HY-D0853

DiAzKs 1 Publications Verification H-L-Photo-lysine	Fluorescent Dye	Others
DiAzKs (H-L-Photo-lysine) is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs acts as a UV light-activated photo-crosslinking probe .

HY-129380A

Fructosyl-lysine dihydrochloride 1 Publications Verification Fructoselysine dihydrochloride	Endogenous Metabolite	Metabolic Disease
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-141522

Cross-linked dextran G 100	Biochemical Assay Reagents	Others
Cross-linked dextran G 100 is a gel filtration medium that can be used for protein purification (Sphere protein separation range: 4K-150K Da; Polysaccharide separation range: 1K-100K Da) .

HY-B0245S

Busulfan-d8	DNA Alkylator/Crosslinker Apoptosis	Inflammation/Immunology Cancer
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-150014

AMT-NHS	Others	Others
AMT-NHS is an RNA-protein crosslinker. AMT-NHS is composed of a psoralen derivative and an N-hydroxysuccinimide ester group which react with RNA bases and primary amines of protein, respectively. AMT-NHS can penetrate into living yeast cells and crosslink Cbf5 to H/ACA snoRNAs with high specificity. AMT-NHS induces different crosslinking patterns and targets both single- and double-stranded regions of RNA. AMT-NHS can be used for capturing diverse RNA-protein interactions in cells .

HY-113033

Pentosidine	Others Biochemical Assay Reagents	Neurological Disease Metabolic Disease Inflammation/Immunology
Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins . Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases .

HY-156045C

Cross-linked dextran G 200	Biochemical Assay Reagents	Others
Cross-linked dextran G 200 is a hydrophilic gel based on molecular size exclusion and targeted macromolecular separation. Cross-linked dextran G 200 works through the gel permeation mechanism, and the cross-linked structure forms a three-dimensional network with a specific pore size, achieving separation based on the molecular hydrodynamic volume. Cross-linked dextran G 200 can be used to adjust the osmotic solute distribution coefficient and the ability to maintain osmotic equilibrium, such as in gel filtration chromatography for purification and analysis of biomacromolecules such as proteins and nucleic acids . Cross-linked dextran G 200 can also be used as a gel filtration filler (particle size range: 40-120 μm; globular protein separation range: 5-600 kDa) .

HY-B0245R

Busulfan (Standard)	DNA Alkylator/Crosslinker Apoptosis Reference Standards	Inflammation/Immunology Cancer
Busulfan (Standard) is the analytical standard of Busulfan. This product is intended for research and analytical applications. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-W043748

2,5-Dioxopyrrolidin-1-yl acrylate N-Succinimidyl acrylate	Biochemical Assay Reagents	Others
2,5-Dioxopyrrolidin-1-yl acrylate (N-Succinimidyl acrylate) is a protein crosslinker. 2,5-Dioxopyrrolidin-1-yl acrylate can react with a monoclonal anti-horseradish peroxidase IgG antibody (anti-HRP) to modify lysine residues .

HY-W106411

DTME Dithio-bis-maleimidoethane	Biochemical Assay Reagents	Others
DTME (dithio-bis-maleimidoethane) is a homobifunctional, maleimide crosslinker specifically designed for conjugation between sulfhydryl groups (-SH). DTME, whose molecular structure consists of two maleimide groups connected by an ethylene disulfide bridge, can specifically react with thiol - containing molecules (such as cysteine residues) to form stable covalent bonds. DTME allows crosslinks that can be cleaved with reducing agents such as DTT (HY-15917). DTME is commonly utilized to explore and characterize protein structure, particularly oligomerization, or protein interactions .

HY-111434

N6-[(2-Azidoethoxy)carbonyl]-L-lysine UAA crosslinker 1	Amino Acid Derivatives	Cancer
N6-[(2-Azidoethoxy) carbonyl]-L-lysine (UAA crosslinker 1) is a click chemistry-reactive amino acid derivative. N6-[(2-Azidoethoxy) carbonyl]-L-lysine mediates the generation of antibody-drug conjugates (ADCs). N6-[(2-Azidoethoxy) carbonyl]-L-lysine is used for site-specific incorporation into recombinant proteins, or for synthesizing chemical probes and tools for biological research .

HY-156045B

Cross-linked dextran G 150	Biochemical Assay Reagents	Others
Cross-linked dextran G 150 is a hydrophilic gel based on molecular size exclusion and targeted for the separation of macromolecules. Cross-linked dextran G 150 functions through the gel permeation mechanism, where the cross-linked structure forms a three-dimensional network with specific pore diameters, achieving separation based on the molecular volumetric flow. Cross-linked dextran G 150 can be used to regulate the distribution coefficient of permeating solutes and maintain the permeation balance, such as in gel filtration chromatography for the purification and analysis of biological macromolecules like proteins and nucleic acids. Cross-linked dextran G 150 can also be used as a gel filtration filler (particle size range: 40-120 μm; spherical protein separation range: 5-300 kDa) .

HY-W013538

1,2-Bis(maleimido)ethane N,N'-Ethylenedimaleimide	Biochemical Assay Reagents	Others
1,2-Bis(maleimido)ethane (N,N'-Ethylenedimaleimide) is a protein cross-linking agent.

HY-W075885

trans-Platinum(II)diammine dichloride trans-platinumdiamminedichloride	DNA Alkylator/Crosslinker	Others
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links .

HY-D0853A

DiAzKs hydrochloride 1 Publications Verification H-L-Photo-lysine hydrochloride	Fluorescent Dye	Others
DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs hydrochloride acts as a UV light-activated photo-crosslinking probe .

HY-117080

Sulfo-EGS	Biochemical Assay Reagents	Others
Sulfo-EGS is a homobifunctional, amine-reactive chemical crosslinker. Sulfo-EGS is used to study protein-protein or protein-peptide interactions, which can determine the spatial proximity of amino acid residues in a protein complex, without relying on standards .

HY-P3026

Bowman-birk inhibitor	Ser/Thr Protease Endogenous Metabolite	Cancer
The Bowman-Birk inhibitor, a highly cross-linked protein featuring seven disulfide bridges, possesses spatially distinct domains specifically designed for the inhibition of both trypsin and chymotrypsin, showcasing its significant role as a plant protease inhibitor with anticarcinogenic properties.

HY-W585874

Nε-(Carboxyethyl)lysine	EAAT Apoptosis	Neurological Disease Metabolic Disease
Nε-(Carboxyethyl) lysine is an advanced glycation end product (AGE). Nε-(Carboxyethyl) lysine induces cross-linking between proteins, thereby affecting protein structure and function and causing protein denaturation. Nε-(Carboxyethyl) lysine binds to the RAGE receptor, affects cell signal transduction, and regulates processes such as inflammatory responses, cell proliferation, and apoptosis. Nε-(Carboxyethyl) lysine affects glutamate transporters, reduces glutamate uptake and S100β protein secretion, influences neurotransmission in the nervous system, and exhibits diabetes-related neurotoxicity .

HY-W096122

DTSSP Crosslinker disodium	Biochemical Assay Reagents	Others
DTSSP Crosslinker disodium is a protein cross-linker containing a disulfide bond. DTSSP Crosslinker disodium can react with sidechains of amino acids that are within close proximity .

HY-159008

NHSF	Biochemical Assay Reagents	Others
NHSF is a protein cross-linking agent .

HY-135066

Triallyl pentaerythritol Pentaerythritol triallyl ether	Biochemical Assay Reagents	Others
Triallyl pentaerythritol (PEATA), a crosslinker, decreases the protein rejection compared to membranes functionalized with MBAA or without any crosslinker .

HY-W104848

4-Maleimidobenzoic acid	Biochemical Assay Reagents	Others
4-Maleimidobenzoic acid is a protein crosslinker. 4-Maleimidobenzoic acid can be used to synthesis maleimidobenzoyl spacers .

HY-135113

DL/meso-Lanthionine	Amino Acid Derivatives	Others
DL/meso-Lanthionine is a mixture of the racemic mixture (DL-) and meso- isomers of Lanthionine. Lanthionine is a non-protein amino acid composed of two alanine residues cross-linked by a thioether bond and is a structural component of the bacterial cell wall.

製品番号	製品名

HY-L060

Cytoskeleton Compound Library

2,148 compounds

The cytoskeleton is responsible for contraction, cell motility, movement of organelles and vesicles through the cytoplasm, cytokinesis, intracellular signal transduction, and many other functions that are essential for cellular homeostasis and survival. It accomplishes these tasks through three basic structures: F-actin, microtubules, and intermediate filaments (IFs). The cytoskeleton is a dynamic structure where the three major filaments and tubules are under the influence of proteins that regulate their length, state of polymerization, and level of cross-linking. Since cytoskeleton is involved in virtually all cellular processes, cytoskeletal protein aberrations are the underlying reason for many pathological phenotypes, including several cardiovascular disease syndromes, neurodegeneration, cancer, liver cirrhosis, pulmonary fibrosis, and blistering skin diseases.

MCE designs a unique collection of 2,148 cytoskeleton-related compounds mainly focusing on the key targets in the cytoskeleton signal pathway and can be used in the research of cytoskeleton signal pathway and related diseases.

HY-LD005

DEL D Kit Cyclic Peptide Library

1.2 billion compounds

Cyclic peptide library have advantages such as high affinity, high selectivity, and suitability for targeting protein–protein interactions. Through DEL synthesis technology, the library size can achieve hundreds of millions. DEL cyclic peptide library have advantages like low cost andhigh screeing efficiency, making them valuable for discovering lead compounds against challenging drug targets.

This cyclic peptide library is constructed with unnatural amino acids as building block, synthesized through DNA-compatible chemical reactions. Each cyclic peptide consist of six amino acids and constrained conformations such as side-chain cross-linking, disulfide bonds, and macrocyclization. These cyclic peptides exhibit significantly improved stability and druggability compared with linear peptides, filling the gap between small molecules and macromolecular biologics. Each cyclic peptide is uniquely conjugated to a DNA barcode sequence for molecular identification and sequencing decoding.

MCE’s cyclic peptide library has8 independent sub-libraries, with a total molecular diversity of 1.2 billion. It is constructed via multi-round combinatorial assembly of building blocks and diverse cyclization strategies, facilitating the discovery of cyclic peptide leads for undruggable targets.

製品番号	製品名	Type

HY-D0853

DiAzKs 1 Publications Verification H-L-Photo-lysine	蛍光色素
DiAzKs (H-L-Photo-lysine) is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs acts as a UV light-activated photo-crosslinking probe .

HY-114354

BODIPY FL alkyne

BOD FL alkyne

蛍光色素

BODIPY (BOD) FL alkyne is an alkyne-containing BODIPY fluorophore derivative. BODIPY FL alkyne is a bioorthogonal labeling reagent with low toxicity and extremely low non-specific reactivity, and it is widely used in fluorescent bioimaging. BODIPY FL alkyne specifically labels azide groups on intracellular glycoconjugates mainly via strain-promoted azide-alkyne cycloaddition (SPAAC), or mediates site-specific conjugation with proteins such as IL-33, and supports positive cross-linking with other probes (e.g., DBCO-SCy5) for dual labeling. With the advantages of high specificity and low background interference, BODIPY FL alkyne can be used in the research of related diseases such as asthma, atopic dermatitis and inflammatory bowel disease .

HY-D0853A

DiAzKs hydrochloride 1 Publications Verification H-L-Photo-lysine hydrochloride	蛍光色素
DiAzKs (H-L-Photo-lysine) hydrochloride is a diazirine-containing lysine amino acid and is a photo-cross-linker. DiAzKs hydrochloride can site-selective incorporated into proteins and is used to crosslink protein-protein interactions in vitro and in living cells. DiAzKs hydrochloride acts as a UV light-activated photo-crosslinking probe .

HY-D2396

Sulfo SMCC R-phycoerythrin Sulfo SMCC R-PE	蛍光色素
Sulfo SMCC R-phycoerythrin is a conjugate composed of the protein crosslinker SMCC (HY-42360) and R-PE (R-Phycoerythrin) (HY-D0988) that can be used to label proteins to make them carry red fluorescence. Among them, SMCC is able to engage antigen-coupled spleen cells to induce antigen-specific immune responses .

HY-D2956

BC-GLA-NHS

CLIP-GLA-NHS

蛍光色素

BC-GLA-NHS (CLIP-GLA-NHS) is a NHS-labeled CLIP tag, which is an amine-reactive crosslinker and can achieve site-specific protein labeling. The NHS ester of BC-GLA-NHS reacts with the primary amine of the target molecule (such as antibodies, quantum dots) in a pH 7.5-8.5 buffer solution to form a stable amide bond. After coupling, the BC molecule undergoes a nucleophilic substitution reaction with the active site (Cys) of the CLIP-tagged fusion protein, releasing benzylcytosine and forming an irreversible thioether bond, achieving covalent labeling. BC-GLA-NHS can be used for click chemistry labeling .

HY-42360G

SMCC

蛍光色素

SMCC (GMP) is the GMP level of SMCC (HY-42360). GMP guidelines are used to produce SMCC (HY-42360) (GMP). GMP small molecules works appropriately as an auxiliary reagent for cell research manufacture. SMCC (GMP) is a protein crosslinker. SMCC (GMP) contains an amine-reactive N-hydroxysuccinimide ester and a sulfhydryl-reactive maleimide group that can be used in the conjugation of proteins. SMCC-conjugated antigen coupled spleen cells to induce antigen-specific immune responses.

HY-D3240

Photoactive NTR probe

蛍光色素

Photoactive NTR probe (Compound 1) is a covalent crosslinker and Fluorescent indicator targeting Nitroreductase. The Photoactive NTR probe undergoes a sequential activation process: it is first activated via nitroreductase-mediated nitro-to-amino conversion, and then forms a fluorescent product upon photoactivation. The Photoactive NTR probe can form covalent adducts with the side chains of cysteine, tyrosine, lysine and histidine in adjacent proteins to reduce fluorophore diffusion. The Photoactive NTR probe enables super-resolution (STORM) imaging of active mitochondrial nitroreductase microdomains in living cells .

製品番号	製品名	Type

HY-Y0623

N-Hydroxysuccinimide

5+ Cited Publications

HOSu; 1-Hydroxy-2,5-pyrrolidinedione

生化学アッセイ試薬

N-Hydroxysuccinimide (HOSu; 1-Hydroxy-2,5-pyrrolidinedione) is a covalent crosslinker commonly used in bioconjugation technology with a primary amine group. N-Hydroxysuccinimide reacts with amino groups (-NH2) to form a stable amide bond, which can modify amino-containing biomolecules. N-Hydroxysuccinimide can be used, for example, for protein labeling with fluorescent dyes and enzymes, surface activation of chromatography supports, microbeads, nanoparticles and microarray slides, and chemical synthesis of peptides. N-Hydroxysuccinimide has a wide range of applications in biomaterial synthesis (such as collagen, chitosan crosslinking), drug delivery systems (such as hydrogel preparation) and tissue engineering .

HY-W074785

Carboxyl diazirine alkyne	生化学アッセイ試薬
Carboxyl diazirine alkyne is a protein cross-linking compound. Carboxyl diazirine alkyne plays a crucial role in the research on the inhibition and labeling of FTO protein by fluorescein derivatives .

HY-148139

Cross-linked dextran G 75	生化学アッセイ試薬
Cross-linked dextran G 75 is a Gel-filtration media. Cross-linked dextran G 75 also is a dextran-based matrix and used for Gel-filtration chromatography (Particle size range: 40-120 μm; Sphere protein separation range: 3K-80K Da; Polysaccharide separation range: 1K-50K Da) .

HY-174892

Biotin-PEG5-NHS ester

生化学アッセイ試薬

Biotin-PEG5-NHS ester is a heterobifunctional crosslinker as well as a polyethylene glycol-containing bioconjugation reagent. Biotin-PEG5-NHS ester is widely used in scientific research fields such as the construction of highly sensitive biosensors, the development of targeted drug delivery systems (e.g., liposome modification), immunofluorescence imaging, and protein affinity purification, and serves as an important tool for achieving precise labeling and functionalization of biomolecules .

HY-138560

Cross-linked dextran G 50 2 Publications Verification	生化学アッセイ試薬
Cross-linked dextran G 50 is a gel filtration medium. Cross-linked dextran G 50 can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da) .

HY-141522

Cross-linked dextran G 100	生化学アッセイ試薬
Cross-linked dextran G 100 is a gel filtration medium that can be used for protein purification (Sphere protein separation range: 4K-150K Da; Polysaccharide separation range: 1K-100K Da) .

HY-78985

Benzene-1,3,5-tricarboxylic acid

Trimesic acid

生化学アッセイ試薬

Benzene-1,3,5-tricarboxylic acid (Trimesic acid) is a rigid planar small-molecule scaffold and crosslinker. Benzene-1,3,5-tricarboxylic acid induces bicyclic peptides to adopt a planar conformation, so as to maximize surface area and bind to the flat protein surfaces involved in protein-protein interactions. Benzene-1,3,5-tricarboxylic acid forms ionic crosslinks, hydrogen bonds and π-π bonds with chitosan, thereby constructing a hydrogel network. Benzene-1,3,5-tricarboxylic acid endows chitosan hydrogel systems with specific mechanical properties, enabling sustained release of cancer therapeutic drugs including 5-Fluorouracil (HY-90006) .

HY-156045C

Cross-linked dextran G 200

生化学アッセイ試薬

Cross-linked dextran G 200 is a hydrophilic gel based on molecular size exclusion and targeted macromolecular separation. Cross-linked dextran G 200 works through the gel permeation mechanism, and the cross-linked structure forms a three-dimensional network with a specific pore size, achieving separation based on the molecular hydrodynamic volume. Cross-linked dextran G 200 can be used to adjust the osmotic solute distribution coefficient and the ability to maintain osmotic equilibrium, such as in gel filtration chromatography for purification and analysis of biomacromolecules such as proteins and nucleic acids . Cross-linked dextran G 200 can also be used as a gel filtration filler (particle size range: 40-120 μm; globular protein separation range: 5-600 kDa) .

HY-156045B

Cross-linked dextran G 150

生化学アッセイ試薬

Cross-linked dextran G 150 is a hydrophilic gel based on molecular size exclusion and targeted for the separation of macromolecules. Cross-linked dextran G 150 functions through the gel permeation mechanism, where the cross-linked structure forms a three-dimensional network with specific pore diameters, achieving separation based on the molecular volumetric flow. Cross-linked dextran G 150 can be used to regulate the distribution coefficient of permeating solutes and maintain the permeation balance, such as in gel filtration chromatography for the purification and analysis of biological macromolecules like proteins and nucleic acids. Cross-linked dextran G 150 can also be used as a gel filtration filler (particle size range: 40-120 μm; spherical protein separation range: 5-300 kDa) .

HY-W075885

trans-Platinum(II)diammine dichloride trans-platinumdiamminedichloride	生化学アッセイ試薬
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links .

HY-W1048851B

4-Arm-PEG10000-Maleimide 4-Arm-PEG10000-Mal	生化学アッセイ試薬
4-Arm-PEG10000-Maleimide (4-Arm-PEG10000-Mal) is a four-arm star-shaped multifunctional PEG crosslinker with an average molecular weight of 10 kDa and maleimide terminal groups. 4-Arm-PEG10000-Maleimide efficiently conjugates biomolecules via thiol-Michael reaction, and is widely used in protein modification, antibody-drug conjugation and biomaterial preparation .

HY-138560A

Cross-linked dextran G 50, medium	生化学アッセイ試薬
Cross-linked dextran G 50, medium is a gel filtration medium. Cross-linked dextran G 50, medium can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, medium are microspheres with an average particle size of D50 = 220-250 μm .

HY-138560B

Cross-linked dextran G 50, fine	生化学アッセイ試薬
Cross-linked dextran G 50, fine is a gel filtration medium. Cross-linked dextran G 50, fine can be used in gel permeation chromatography for fractionation of the glycopeptide mixture (Sphere protein separation range: 1.5K-30K Da; Polysaccharide separation range: 500-10K Da). Cross-linked dextran G 50, fineThe average particle size is D50=110-130 μmof microspheres .

HY-174358D

HOOC-PEG10000-COOH	生化学アッセイ試薬
HOOC-PEG10000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG10000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-156045

Cross-linked dextran G 15	生化学アッセイ試薬
Cross-linked dextran G 15 is a hydrophilic gel that can be used as a gel filter filler (Sphere protein separation range: >1500 Da; Polysaccharide separation range: >1500 Da) .

HY-156045A

Cross-linked dextran G 10	生化学アッセイ試薬
Cross-linked dextran G 10 is a weak cation exchanger and a hydrophilic gel that can be used as a gel filter filler (Sphere protein separation range: >700 Da; Polysaccharide separation range: >700 Da) .

HY-174358A

HOOC-PEG2000-COOH	生化学アッセイ試薬
HOOC-PEG2000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG2000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-174358E

HOOC-PEG20000-COOH	生化学アッセイ試薬
HOOC-PEG20000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG20000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-W127719

Photobiotin acetate

生化学アッセイ試薬

Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W414754

2,5-Dioxopyrrolidin-1-yl methyl phthalate	生化学アッセイ試薬
2,5-Dioxopyrrolidin-1-yl methyl phthalate is a cross-linking agent used for modification of proteins and peptides. 2,5-Dioxopyrrolidin-1-yl methyl phthalate is a reagent for introducing succinimide-activated esters that react with primary amines in proteins and peptides to form stable amide bonds.

HY-W075885R

trans-Platinum(II)diammine dichloride (Standard)

trans-platinumdiamminedichloride (Standard)

生化学アッセイ試薬

trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) (Standard) is an analytical standard for trans-Platinum(II)diammine dichloride (HY-W075885). This product is intended for research and analytical applications. trans-Platinum(II)diammine dichloride is a geometric isomer of Cisplatin (HY-17394). trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage but exhibits low cytotoxicity. trans-Platinum(II)diammine dichloride can be used to study DNA-protein cross-links.

HY-174358C

HOOC-PEG5000-COOH	生化学アッセイ試薬
HOOC-PEG5000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG5000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-174358

HOOC-PEG1000-COOH	生化学アッセイ試薬
HOOC-PEG1000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG1000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-174358H

HOOC-PEG40000-COOH	生化学アッセイ試薬
HOOC-PEG40000-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG40000-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-174358B

HOOC-PEG3400-COOH	生化学アッセイ試薬
HOOC-PEG3400-COOH has two active carboxyl groups at both ends, which can selectively react with the amino groups in peptide coupling agents. HOOC-PEG3400-COOH is a good cross-linking agent for PEGylation of proteins and peptides, nanoparticles and surface modification .

HY-42360G

SMCC

生化学アッセイ試薬

製品番号	製品名	Target	研究分野

HY-135113

DL/meso-Lanthionine	Amino Acid Derivatives	Others
DL/meso-Lanthionine is a mixture of the racemic mixture (DL-) and meso- isomers of Lanthionine. Lanthionine is a non-protein amino acid composed of two alanine residues cross-linked by a thioether bond and is a structural component of the bacterial cell wall.

HY-P11661

DC-peptoid-1	Epigenetic Reader Domain	Inflammation/Immunology
DC-peptoid-1 is a specific binder and crosslinker targeting the phosphorylated Brd4 PDID domain, with a dissociation constant (K_d) of approximately 50-100 μM for human-derived targets. DC-peptoid-1 only binds to phosphorylated PDID and fails to recognize the non-phosphorylated form or other domains (such as Brd4 598-785). DC-peptoid-1 effectively crosslinks with the target protein both in solution and cell lysates. It can successfully capture phosphorylated PDID from complex systems via immobilization, without binding to bacterial-derived non-phosphorylated proteins or other non-specific phosphoproteins. DC-peptoid-1 has the potential to serve as a phosphoprotein-specific antibody substitute for applications such as immunoaffinity purification .

製品番号	製品名

HY-K0213

Protein A Agarose 5 Publications Verification
MCE Protein A Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein A, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG, IgE, IgM.

HY-K0215

Protein L Agarose 1 Publications Verification
MCE Protein L Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein L, effectively purifies mammalian monoclonal and polyclonal antibodies which have kappa light chain.

HY-K0211

Glutathione Agarose 5+ Cited Publications
MCE Glutathione Agarose, a 4% highly cross-linked agarose reagent, enables high-yield, high-purity purification of GST-tagged proteins.

HY-K0214

Protein G Agarose 5+ Cited Publications
MCE Protein G Agarose, a 4% highly cross-linked agarose reagent coupled with recombinant Protein G, effectively purifies mammalian monoclonal and polyclonal antibodies, such as human IgG3 and rat IgG2a.

HY-K0210

Ni-NTA His-Tag Purification Agarose Maximum Cited Publications 30 Publications Verification
MCE Ni-NTA His-Tag Purification Agarose, a 6% highly cross-linked agarose reagent, enables high-yield, high-purity purification of his-tagged proteins.

HY-K0219

High-Affinity Iodoacetyl Agarose 1 Publications Verification
MCE High-Affinity Iodoacetyl Agarose, a 4% highly cross-linked agarose reagent coupled with a derivative of iodoacetic acid, is ideal for conjugating sulfhydryl-containing peptide or protein for subsequent affinity purification.

製品番号	製品名	Target	研究分野	Image

HY-P99047

Simtuzumab AB 0024; GS 6624	Monoamine Oxidase	Cardiovascular Disease Inflammation/Immunology
Simtuzumab (AB 0024; GS 6624) is a monoclonal antibody directed against Lysyl oxidase like-2 (LOXL2). Simtuzumab non-competitively blocks collagen cross-linking, reduces LOXL2 protein expression and attenuates extracellular matrix changes. Simtuzumab reduces myocardial fibrosis and prevents cardiac dysfunction. Simtuzumab lowers Myh7 and Nppa gene expression, reduces contraction heterogeneity, and cuts COL1A1 deposition. Simtuzumab can be used for the research of LMNA mutation-induced dilated cardiomyopathy, idiopathic pulmonary fibrosis, and primary sclerosing cholangitis .

製品番号	製品名	Category	Target	構造式

HY-129380

Fructosyl-lysine 1 Publications Verification Fructoselysine	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes?detection .

HY-N1470

Plantagoside	Plantaginaceae Structural Classification Flavonoids Classification of Application Fields Flavonones Phenols Polyphenols Metabolic Disease Plantago asiatica L. Plants Disease Research Fields Source Classification	Glycosidase
Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .

HY-129380A

Fructosyl-lysine dihydrochloride 1 Publications Verification Fructoselysine dihydrochloride	天然物 Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine–arginine protein cross-link that can be an indicator in diabetes detection .

HY-113033

Pentosidine	Structural Classification 天然物 Disease markers Endogenous metabolite Source Classification	Others Biochemical Assay Reagents
Pentosidine is a fluorescent advanced glycation end product (AGE) and cross-linker. Pentosidine is a fluorescent cross-linked structure formed by lysine and arginine in sugar oxidation reactions, and it is commonly found in collagen, skin, bone, lens and plasma proteins . Pentosidine is used in research related to type 1 diabetes, brown cataracts, rheumatoid arthritis, atherosclerosis and neurodegenerative diseases .

HY-129380AR

Fructosyl-lysine dihydrochloride (Standard) Fructoselysine dihydrochloride (Standard)	Structural Classification 天然物 Endogenous metabolite Source Classification	Endogenous Metabolite Reference Standards
Fructosyl-lysine (dihydrochloride) (Standard) is the analytical standard of Fructosyl-lysine (dihydrochloride). This product is intended for research and analytical applications. Fructosyl-lysine (Fructoselysine) dihydrochloride is an amadori glycation product from the reaction of glucose and lysine by the Maillard reaction. Fructosyl-lysine dihydrochloride is the precursor to glucosepane, a lysine-arginine protein cross-link that can be an indicator in diabetes detection .

HY-N1470R

Plantagoside (Standard)	Plantaginaceae Structural Classification Flavonoids Flavonones Phenols Polyphenols Plantago asiatica L. Plants Source Classification	Reference Standards Glycosidase
Plantagoside (Standard) is the analytical standard of Plantagoside (HY-N1470). This product is intended for research and analytical applications. Plantagoside is a flavanone glucoside found in Plantago asiatica seeds, acting as a specific non-competitive α-mannosidase inhibitor with IC₅₀ values of 5 μM and a K_i of 2.7 μM (jack bean). Plantagoside suppresses antibody response and Concanavalin A (HY-P2149)-induced lymphocyte proliferation in mouse spleen cells. Plantagoside inhibits the Maillard reaction, advanced glycation end product formation, and glycation-dependent protein-protein cross-link formation. Plantagoside can be used for the research of diabetes .

製品番号	製品名	構造式

HY-B0245S

Busulfan-d8
Busulfan-d₈ is a deuterium labeled Busulfan. Busulfan is a potent alkylating antineoplastic agent. Busulfan causes DNA damage by cross-linking DNAs and DNA and proteins. Busulfan inhibits thioredoxin reductase. Busulfan induces apoptosis. Busulfan is an immunosuppressive and myeloablative chemotherapeutic agent .

HY-118759S

DSP Crosslinker-d8
DSP Crosslinker-d₈ is the deuterium labeled DSP Crosslinker (HY-118759). DSP Crosslinker is an amine-reactive and cleavable protein crosslinker. DSP Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-114697S

DSG Crosslinker-d4
DSG Crosslinker-d₄ (Disuccinimidyl glutarate-d₄) is the deuterium labeled DSG Crosslinker (HY-114697). DSG Crosslinker is an amine-reactive and noncleavable protein crosslinker. DSG Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-W705390

Disuccinimidyl suberate Crosslinker-d4
Disuccinimidyl suberate Crosslinker-d₄ is the deuterium labeled Disuccinimidyl suberate Crosslinker (HY-W019543). Disuccinimidyl suberate Crosslinker is an amine-reactive bifunctional protein crosslinker. Disuccinimidyl suberate Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

HY-78985S

Benzene-1,3,5-tricarboxylic acid-d3

Benzene-1,3,5-tricarboxylic acid-d₃ (Trimesic acid-d₃) is the deuterium labeled Benzene-1,3,5-tricarboxylic acid (HY-78985). Benzene-1,3,5-tricarboxylic acid (Trimesic acid) is a rigid planar small-molecule scaffold and crosslinker. Benzene-1,3,5-tricarboxylic acid induces bicyclic peptides to adopt a planar conformation, so as to maximize surface area and bind to the flat protein surfaces involved in protein-protein interactions. Benzene-1,3,5-tricarboxylic acid forms ionic crosslinks, hydrogen bonds and π-π bonds with chitosan, thereby constructing a hydrogel network. Benzene-1,3,5-tricarboxylic acid endows chitosan hydrogel systems with specific mechanical properties, enabling sustained release of cancer therapeutic drugs including 5-Fluorouracil (HY-90006) .

HY-124329AS

BS3 Crosslinker-d4 disodium
BS3 Crosslinker-d₄ disodium is the deuterium labeled BS3 Crosslinker. BS3 Crosslinker disodium is an amine-reactive homobifunctional protein crosslinker. BS3 Crosslinker disodium enables stable protein-protein, peptide, and biomolecule conjugation.

HY-130547S

BS2G Crosslinker-d4 disodium
BS2G Crosslinker-d₄ disodium is the deuterium labeled BS2G Crosslinker disodium (HY-130547). BS2G Crosslinker is an amine-reactive homobifunctional protein crosslinker. BS2G Crosslinker enables stable protein-protein, peptide, and biomolecule conjugation.

製品番号	製品名		Classification

HY-W074785

Carboxyl diazirine alkyne		Alkynes
Carboxyl diazirine alkyne is a protein cross-linking compound. Carboxyl diazirine alkyne plays a crucial role in the research on the inhibition and labeling of FTO protein by fluorescein derivatives .

HY-W035129

endo-BCN-NHS carbonate		BCN
endo-BCN-NHS carbonate is an elastin-like protein (ELP) modification reagent. endo-BCN-NHS carbonate can react with lysine residues in ELP to make ELP carry BCN groups, and then cross-link ELP through strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. endo-BCN-NHS carbonate promotes hydrogel formation. endo-BCN-NHS carbonate is mainly used in cell encapsulation related research .

HY-111434A

N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride UAA crosslinker 1 hydrochloride		Azide
N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride (UAA crosslinker 1 hydrochloride) is a click chemistry-reactive amino acid derivative. N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride mediates the generation of antibody-drug conjugates (ADCs). N6-[(2-Azidoethoxy)carbonyl]-L-lysine hydrochloride is used for site-specific incorporation into recombinant proteins, or for synthesizing chemical probes and tools for biological research .

HY-111434

N6-[(2-Azidoethoxy)carbonyl]-L-lysine UAA crosslinker 1		Azide
N6-[(2-Azidoethoxy) carbonyl]-L-lysine (UAA crosslinker 1) is a click chemistry-reactive amino acid derivative. N6-[(2-Azidoethoxy) carbonyl]-L-lysine mediates the generation of antibody-drug conjugates (ADCs). N6-[(2-Azidoethoxy) carbonyl]-L-lysine is used for site-specific incorporation into recombinant proteins, or for synthesizing chemical probes and tools for biological research .

HY-151791

(S,R,S)-AHPC-C6-PEG3-butyl-N3		Azide
(S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent containing an azide group. (S,R,S)-AHPC-C6-PEG3-butyl-N3 serves as crosslinker-E3 ligase ligand conjugate, Click reactive protein degrader building block for PROTAC research, Template for synthesis of targeted protein degrader, VH032 conjugate . (S,R,S)-AHPC-C6-PEG3-butyl-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

HY-W127719

Photobiotin acetate		Azide
Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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