4-Maleimidobenzoic acid

Cat. No.: HY-W104848 Purity: 99.76%: Data Sheet
COA

SDS
Handling Instructions
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4-Maleimidobenzoic acid is a protein crosslinker. 4-Maleimidobenzoic acid can be used to synthesis maleimidobenzoyl spacers.

For research use only. We do not sell to patients.

4-Maleimidobenzoic acid Chemical Structure

CAS No. : 17057-04-4

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 g	In-stock	Estimated Time of Arrival: December 31
5 g	In-stock	Estimated Time of Arrival: December 31
10 g	In-stock	Estimated Time of Arrival: December 31
25 g	In-stock	Estimated Time of Arrival: December 31
50 g	Get quote

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Biological Activity
Purity & Documentation
References
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Description

4-Maleimidobenzoic acid is a protein crosslinker. 4-Maleimidobenzoic acid can be used to synthesis maleimidobenzoyl spacers^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MT2	CC₅₀	> 400 μM Compound: B13	Cytotoxicity against human MT2 cells after 4 days by XTT assay Cytotoxicity against human MT2 cells after 4 days by XTT assay	[PMID: 19053778]
MT2	EC₅₀	205.44 μM Compound: B13	Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA Antiviral activity against HIV1 3B in human MT2 cells assessed as inhibition of p24 antigen level after 4 days by ELISA	[PMID: 19053778]

Molecular Weight

217.18

Formula

C₁₁H₇NO₄

CAS No.

17057-04-4

Appearance

Solid

Color

White to off-white

SMILES

C1=C(C=CC(=C1)N2C(=O)C=CC2=O)C(=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (460.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6045 mL	23.0224 mL	46.0448 mL
5 mM	0.9209 mL	4.6045 mL	9.2090 mL
10 mM	0.4604 mL	2.3022 mL	4.6045 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.76%

Select Batch:

Data Sheet (271 KB) SDS (392 KB)

COA (253 KB) HNMR (128 KB) RP-HPLC (85 KB)

Handling Instructions (2659 KB)

References

[1]. Lau A, et, al. Conjugation of doxorubicin to monoclonal anti-carcinoembryonic antigen antibody via novel thiol-directed cross-linking reagents. Bioorg Med Chem. 1995 Oct;3(10):1299-304. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6045 mL	23.0224 mL	46.0448 mL	115.1119 mL
	5 mM	0.9209 mL	4.6045 mL	9.2090 mL	23.0224 mL
	10 mM	0.4604 mL	2.3022 mL	4.6045 mL	11.5112 mL
	15 mM	0.3070 mL	1.5348 mL	3.0697 mL	7.6741 mL
	20 mM	0.2302 mL	1.1511 mL	2.3022 mL	5.7556 mL
	25 mM	0.1842 mL	0.9209 mL	1.8418 mL	4.6045 mL
	30 mM	0.1535 mL	0.7674 mL	1.5348 mL	3.8371 mL
	40 mM	0.1151 mL	0.5756 mL	1.1511 mL	2.8778 mL
	50 mM	0.0921 mL	0.4604 mL	0.9209 mL	2.3022 mL
	60 mM	0.0767 mL	0.3837 mL	0.7674 mL	1.9185 mL
	80 mM	0.0576 mL	0.2878 mL	0.5756 mL	1.4389 mL
	100 mM	0.0460 mL	0.2302 mL	0.4604 mL	1.1511 mL