BS3 Crosslinker-d4 disodium
BS3 Crosslinker-d4 disodium is the deuterated-labeled BS3 Crosslinker disodium (HY-124329A). BS3 Crosslinker disodium is a cell-impermeable NHS ester crosslinker. BS3 Crosslinker disodium "covalently locks" two spatially adjacent proteins on the surface of living cells into a covalent complex, and the dimerization/oligomerization status is determined by observing molecular weight shifts via Western blot. BS3 Crosslinker disodium can crosslink EGFR and c-MET to assist in detecting and evaluating their dimerization status. It can be used in research related to oral cancer and glioblastoma.
For research use only. We do not sell to patients.
- CAS No.: 910292-87-4
- Formula: C16H14D4N2Na2O14S2
- Molecular Weight:576.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Application
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS No. 910292-87-4
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Unlabeled CAS 127634-19-9
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Molecular Weight 576.45
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Formula C16H14D4N2Na2O14S2
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SMILES
O=C(C(CC1=O)S(=O)(O[Na])=O)N1OC(C([2H])([2H])CCCCC([2H])([2H])C(ON2C(C(CC2=O)S(=O)(O[Na])=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chen S, et al. LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer. International journal of oral science. 2025 Sep 12;17(1):64. [Content Brief]
[2]. Wang Y, et al. S-palmitoylation of c-MET by CK2α-mediated zDHHC15 phosphorylation drives glioblastoma stem cell tumorigenicity. Neuro-oncology. 2025 Sep 17;27(8):1972-1986. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BS3 Crosslinker-d4 disodium Related Classifications
HY-124329AS Related Classifications
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