1. Antibody-drug Conjugate/ADC Related
  2. ADC Linker
  3. BS3 Crosslinker disodium

BS3 Crosslinker disodium 

Cat. No.: HY-124329A
Handling Instructions

BS3 Crosslinker disodium is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

BS3 Crosslinker disodium Chemical Structure

BS3 Crosslinker disodium Chemical Structure

CAS No. : 127634-19-9

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Description

BS3 Crosslinker disodium is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Non-cleavable

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].

Molecular Weight

572.43

Formula

C₁₆H₁₈N₂Na₂O₁₄S₂

CAS No.

127634-19-9

SMILES

O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCCCCCC(ON2C(C(S(=O)(O[Na])=O)CC2=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (218.37 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7469 mL 8.7347 mL 17.4694 mL
5 mM 0.3494 mL 1.7469 mL 3.4939 mL
10 mM 0.1747 mL 0.8735 mL 1.7469 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.63 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

BS3 Crosslinker disodiumADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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Product name:
BS3 Crosslinker disodium
Cat. No.:
HY-124329A
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