127634-19-9
Chemical Structure
BS3 Crosslinker disodium
- CAS No.: 127634-19-9
- Formula:C16H18N2Na2O14S2
- Molecular Weight:572.43
IUPAC Name: sodium 1,1'-(octanedioylbis(oxy))bis(2,5-dioxopyrrolidine-3-sulfonate)
InChIKey: MGJYOHMBGJPESL-UHFFFAOYSA-L
SMILES: O=C(ON1C(C(S(=O)(O[Na])=O)CC1=O)=O)CCCCCCC(ON2C(C(S(=O)(O[Na])=O)CC2=O)=O)=O
Biological Activity: BS3 Crosslinker disodium is a cell-impermeable NHS ester crosslinker. BS3 Crosslinker disodium "covalently locks" two spatially adjacent proteins on the surface of living cells into a covalent complex, and the dimerization/oligomerization status is determined by observing molecular weight shifts via Western blot. BS3 Crosslinker disodium can crosslink EGFR and c-MET to assist in detecting and evaluating their dimerization status. It can be used in research related to oral cancer and glioblastoma[1][2].
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BS3 Crosslinker disodium | 98.0% | BS3 Crosslinker disodium is a cell-impermeable NHS ester crosslinker. BS3 Crosslinker disodium "covalently locks" two spatially adjacent proteins on the surface of living cells into a covalent complex, and the dimerization/oligomerization status is determined by observing molecular weight shifts via Western blot. BS3 Crosslinker disodium can crosslink EGFR and c-MET to assist in detecting and evaluating their dimerization status. It can be used in research related to oral cancer and glioblastoma. | ||||||||||||||||||||
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BS3 Crosslinker-d4 disodium | BS3 Crosslinker-d4 disodium is the deuterated-labeled BS3 Crosslinker disodium (HY-124329A). BS3 Crosslinker disodium is a cell-impermeable NHS ester crosslinker. BS3 Crosslinker disodium "covalently locks" two spatially adjacent proteins on the surface of living cells into a covalent complex, and the dimerization/oligomerization status is determined by observing molecular weight shifts via Western blot. BS3 Crosslinker disodium can crosslink EGFR and c-MET to assist in detecting and evaluating their dimerization status. It can be used in research related to oral cancer and glioblastoma. | |||||||||||||||||||||
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- [1]. Chen S, et al. LncRNA EUDAL shapes tumor cell response to hypoxia-induced constitutive EGFR activation and promotes chemoresistance in oral cancer. International journal of oral science. 2025 Sep 12;17(1):64. [Content Brief]
- [2]. Wang Y, et al. S-palmitoylation of c-MET by CK2α-mediated zDHHC15 phosphorylation drives glioblastoma stem cell tumorigenicity. Neuro-oncology. 2025 Sep 17;27(8):1972-1986. [Content Brief]
