2. Metabolic Enzyme/Protease
  3. Glutaminase
  4. TTGM 5826

TTGM 5826 is a tissue transglutaminase (tTG) inhibitor with an EC50 of 20 μM. TTGM 5826 stabilizes the open conformation of tTG that exhibits protein cross-linking activity, and acts as a competitive inhibitor of tTG-mediated cross-linking activity. TTGM 5826 inhibits the transformed phenotypes of breast cancer cells, brain cancer cells and glioma stem cells. TTGM 5826 can be used in the research of breast cancer, glioblastoma, pancreatic cancer and glioma stem cell-related tumors.

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TTGM 5826

TTGM 5826 Chemical Structure

CAS No. : 330471-93-7

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Description

TTGM 5826 is a tissue transglutaminase (tTG) inhibitor with an EC50 of 20 μM. TTGM 5826 stabilizes the open conformation of tTG that exhibits protein cross-linking activity, and acts as a competitive inhibitor of tTG-mediated cross-linking activity. TTGM 5826 inhibits the transformed phenotypes of breast cancer cells, brain cancer cells and glioma stem cells. TTGM 5826 can be used in the research of breast cancer, glioblastoma, pancreatic cancer and glioma stem cell-related tumors[1].

In Vitro

TTGM 5826 (30 μM; 6 days) potently inhibits the growth of onco-Dbl-transformed MEF cells, while exerting minimal effects on untransformed MEF cells[1].
TTGM 5826 (6 days) inhibits the growth of tTG-expressing cancer cell lines and GSCs, with IC50 values ranging from 11 μM (GSC267) to 30 μM (Mia-PaCa-2, U-87 MG); it shows no effect on tTG-negative T47D and HME-1 cells, and exhibits enhanced activity against T98G cells with retinoic acid (HY-14649)-induced tTG upregulation[1].
TTGM 5826 (15 μM; 12-36 h) significantly inhibits the migration of MDA-MB-231, U-87 MG and LN229 cancer cells[1].
TTGM 5826 (15-30 μM; 10 days) completely blocks colony formation of MDA-MB-231 cells and potently inhibits colony formation of LN229 cells[1].
TTGM 5826 (30-120 μM; 14 days) inhibits the anchorage-independent growth of LN229 and U-87 MG glioblastoma cells in a dose-dependent manner, with an inhibition rate of approximately 80%-85% at concentrations of 60-120 μM[1].
TTGM 5826 (6.3-50.0 μM; 3 days) inhibits sphere formation (a marker of stem cell properties) in GSC374 and GSC267 glioma stem cells in a dose-dependent manner, and almost completely abolishes sphere formation at 50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TTGM 5826 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: onco-Dbl-transformed mouse embryonic fibroblasts (MEFs), non-transformed control MEFs
Concentration: 30 μM
Incubation Time: 6 days
Result: Potently inhibited the growth of onco-Dbl-transformed MEFs, while having minimal effect on non-transformed control MEFs.

Cell Migration Assay[1]

Cell Line: MDA-MB-231, U-87 MG, LN229
Concentration: 15 μM
Incubation Time: 12-36 h (until wound closure in control cultures)
Result: Inhibited migration by ~30% in MDA-MB-231 cells, ~50% in U-87 MG cells, and ~40% in LN229 cells.
Molecular Weight

480.47

Formula

C27H20N4O5
CAS No.
SMILES

O=C1NC(/C(C(N1C2=CC=CC=C2)=O)=C\NC3=CC=C(C)C(CN(C(C4=C5C=CC=C4)=O)C5=O)=C3)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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TTGM 5826 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TTGM 5826330471-93-7TTGM5826TTGM-5826Glutaminaseglioma stem cellsbrain cancer cellstTGbreast cancer cellsMEFsMDA-MB-231pancreatic cancertissue transglutaminasebreast cancerglioblastomaInhibitorinhibitorinhibit

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