330471-93-7
Chemical Structure
TTGM 5826
- CAS No.: 330471-93-7
- Formula:C27H20N4O5
- Molecular Weight:480.47
IUPAC Name: (E)-5-(((3-((1,3-dioxoisoindolin-2-yl)methyl)-4-methylphenyl)amino)methylene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
InChIKey: KWMHLXLINLFRFA-HYARGMPZSA-N
SMILES: O=C1NC(/C(C(N1C2=CC=CC=C2)=O)=C\NC3=CC=C(C)C(CN(C(C4=C5C=CC=C4)=O)C5=O)=C3)=O
Biological Activity: TTGM 5826 is a tissue transglutaminase (tTG) inhibitor with an EC50 of 20 μM. TTGM 5826 stabilizes the open conformation of tTG that exhibits protein cross-linking activity, and acts as a competitive inhibitor of tTG-mediated cross-linking activity. TTGM 5826 inhibits the transformed phenotypes of breast cancer cells, brain cancer cells and glioma stem cells. TTGM 5826 can be used in the research of breast cancer, glioblastoma, pancreatic cancer and glioma stem cell-related tumors[1].
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TTGM 5826 | TTGM 5826 is a tissue transglutaminase (tTG) inhibitor with an EC50 of 20 μM. TTGM 5826 stabilizes the open conformation of tTG that exhibits protein cross-linking activity, and acts as a competitive inhibitor of tTG-mediated cross-linking activity. TTGM 5826 inhibits the transformed phenotypes of breast cancer cells, brain cancer cells and glioma stem cells. TTGM 5826 can be used in the research of breast cancer, glioblastoma, pancreatic cancer and glioma stem cell-related tumors. | |||||||||||||||||||||
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Keywords
