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  3. Biochemical Assay Reagents
  4. EY-CBS

EY-CBS is a synthetic and rigid cross linker. EY-CBS reacts selectively with cysteines in a-helices, to stabilize the connecting helix. EY-CBS can be used for the study of the structural stability of protein polypeptides.

For research use only. We do not sell to patients.

EY-CBS

EY-CBS Chemical Structure

CAS No. : 960294-74-0

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EY-CBS Related Antibodies

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Description

EY-CBS is a synthetic and rigid cross linker. EY-CBS reacts selectively with cysteines in a-helices, to stabilize the connecting helix. EY-CBS can be used for the study of the structural stability of protein polypeptides[1].
Molecular Weight

521.35

Formula

C18H14Cl2N2O8S2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(CCl)NC1=CC=C(C(S(=O)(O)=O)=C1)C#CC2=CC=C(NC(CCl)=O)C=C2S(=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (191.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9181 mL 9.5905 mL 19.1810 mL
5 mM 0.3836 mL 1.9181 mL 3.8362 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9181 mL 9.5905 mL 19.1810 mL 47.9524 mL
5 mM 0.3836 mL 1.9181 mL 3.8362 mL 9.5905 mL
10 mM 0.1918 mL 0.9590 mL 1.9181 mL 4.7952 mL
15 mM 0.1279 mL 0.6394 mL 1.2787 mL 3.1968 mL
20 mM 0.0959 mL 0.4795 mL 0.9590 mL 2.3976 mL
25 mM 0.0767 mL 0.3836 mL 0.7672 mL 1.9181 mL
30 mM 0.0639 mL 0.3197 mL 0.6394 mL 1.5984 mL
40 mM 0.0480 mL 0.2398 mL 0.4795 mL 1.1988 mL
50 mM 0.0384 mL 0.1918 mL 0.3836 mL 0.9590 mL
60 mM 0.0320 mL 0.1598 mL 0.3197 mL 0.7992 mL
80 mM 0.0240 mL 0.1199 mL 0.2398 mL 0.5994 mL
100 mM 0.0192 mL 0.0959 mL 0.1918 mL 0.4795 mL
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EY-CBS Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EY-CBS960294-74-0Biochemical Assay ReagentsChemical crosslinkerAlpha-helix stabilizationProtein engineeringStructure predictionBifunctional reagentCysteine-specific reactionRigid spacerFusion proteinX-ray crystallographyInhibitorinhibitorinhibit

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