2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. DSP Crosslinker

DSP Crosslinker 

Cat. No.: HY-118759 Purity: 98.73%
COA Handling Instructions

DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs).

For research use only. We do not sell to patients.

DSP Crosslinker Chemical Structure

DSP Crosslinker Chemical Structure

CAS No. : 57757-57-0

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250 mg USD 140 In-stock
500 mg USD 220 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

DSP Crosslinker Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE DSP Crosslinker

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View All Isoforms
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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

DSP Crosslinker is a cleavable ADC linker, used in the synthesis of antibody-drug conjugates (ADCs)[1].

IC50 & Target

Disulfide Cleavable Linker

 

Cleavable Linker

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DSP Crosslinker Related Antibodies
Molecular Weight

404.42

Appearance

Solid

Formula

C14H16N2O8S2
CAS No.
SMILES

O=C(CCSSCCC(ON1C(CCC1=O)=O)=O)ON2C(CCC2=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (123.63 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4727 mL 12.3634 mL 24.7268 mL
5 mM 0.4945 mL 2.4727 mL 4.9454 mL
10 mM 0.2473 mL 1.2363 mL 2.4727 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (6.18 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 98.73%

COA (248 KB) HNMR (122 KB) LCMS (103 KB)

Handling Instructions (2659 KB)
References
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DSP Crosslinker Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DSP Crosslinker57757-57-0ADC LinkerAntibody-drug conjugates linkercleavableADClinkerInhibitorinhibitorinhibit

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