Propanedial (13.88 mM in water)  (Synonyms: Malondialdehyde)

Propanedial (Malondialdehyde) (13.88 mM in water) is one of the final products of lipid peroxidation. Propanedial causes protein inactivation, DNA damage and cross-linking by forming stable covalent adducts with biological macromolecules, which is the main mechanism for its cytotoxicity and genotoxicity. Propanedial production increases with the elevation of free radicals. Propanedial is a key biomarker for evaluating the level of cellular oxidative stress^[1][2][3].

Propanedial can easily react with nucleophilic sites on biological macromolecules such as proteins and DNA (such as the ε-amino group of lysine), forming stable covalent adducts. The accumulation of excessive Propanedial and its adducts is an important aspect of the pathological processes of various aging-related diseases and mental disorders such as bipolar disorder^[1][2][3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

72.06

C₃H₄O₂

542-78-9

Liquid

Colorless to light yellow

O=CCC=O

Shipping with dry ice.

Solution, -20°C, 1 year

• [1]. Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev. 2014;2014:360438.  [Content Brief]

  [2]. Capuzzi E, Ossola P, Caldiroli A, Auxilia AM, Buoli M. Malondialdehyde as a candidate biomarker for bipolar disorder: A meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Mar 8;113:110469.  [Content Brief]

  [3]. Gaweł S, et al. Malondialdehyde (MDA) as a lipid peroxidation marker. Wiad Lek. 2004;57(9-10):453-5. Polish.  [Content Brief]