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RAW264.7+cells

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) AMPK (1) Antibiotic (1) Apoptosis (6) Bacterial (5) Calcium Channel (2) Caspase (4) Cathepsin (1) CD28 (1) Cholinesterase (ChE) (2) COX (7) Cyclic GMP-AMP Synthase (1) Drug Derivative (2) Drug Metabolite (1) EBV (1) Endogenous Metabolite (3) ERK (3) Glycosidase (2) HDAC (1) Heme Oxygenase (HO) (1) HIV Protease (1) HSV (1) IKK (1) Indoleamine 2,3-Dioxygenase (IDO) (1) Interleukin Related (16) JAK (1) JNK (3) Keap1-Nrf2 (2) Lipoxygenase (2) NF-κB (20) NO Synthase (41) NOD-like Receptor (NLR) (2) Nuclear Factor of activated T Cells (NFAT) (1) p38 MAPK (1) PGE synthase (1) Phosphatase (2) PI3K (1) PPAR (5) PROTACs (1) Pyroptosis (2) RANKL/RANK (1) Reactive Oxygen Species (ROS) (10) Reference Standards (5) Src (1) STAT (2) STING (2) TNF Receptor (15) Toll-like Receptor (TLR) (3)
By Research Areas:	Cancer (12) Cardiovascular Disease (11) Infection (4) Inflammation/Immunology (85) Metabolic Disease (12) Neurological Disease (3)
Click Chemistry:	Azide (1) Alkynes (2)

108

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Peptides

Natural
Products

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-111152

ML115 Maximum Cited Publications 6 Publications Verification	STAT	Cancer
ML115, a molecular probe of the signal transducer, is a selective STAT3 agonist, with an EC₅₀ of 2 nM. ML115 increases the expression of BCL3, a known STAT3-dependent oncogene. ML115 is inactive against the related STAT1, STAT5 and NF-κB anti-targets. ML115 counteracts the effects of Ginsenoside Rc (HY-N0042) on cell viability and inflammatory responses in LPS (HY-D1056)-stimulated H9c2 and RAW264.7 cells, while altering oxidative stress markers. ML115 can be used for the study of breast and prostate cancers .

HY-N6636

Valencene 1 Publications Verification	NF-κB Interleukin Related	Inflammation/Immunology
Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model .

HY-N0634

Cimifugin 1 Publications Verification Cimitin	NF-κB	Inflammation/Immunology
Cimifugin (Cimitin) is a bioactive component of Cimicifuga racemosa, a Chinese herb. Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions . Cimifugin reduces the migration and chemotaxis of RAW264.7 cells and inhibits the release of inflammatory factors and activation of MAPKs and NF-κB signaling pathways induced by LPS .

HY-107825

Flavonol 2 Publications Verification	Endogenous Metabolite Bacterial Cholinesterase (ChE)	Cardiovascular Disease Metabolic Disease Inflammation/Immunology Cancer
Flavonol is a cholinesterase (ChE) inhibitor, with an IC₅₀ value of 120 μM and a K_i value of 74 μM. Flavonol has antioxidant, free radical-scavenging, antibacterial properties, and immune modulation functions. Flavonol inhibits the PriA helicase of Staphylococcus aureus. Flavonol can suppress the production of NO in LPS-activated RAW 264.7 cells by inhibiting the expression of the iNOS enzyme. Flavonol shows protective and analgesic effects in mice through various neuronal pathways. Flavonol can be used in research related to tumors and atherosclerosis diseases .

HY-N0617

Sanggenon C 2 Publications Verification	Phosphatase ERK NF-κB Apoptosis	Cardiovascular Disease Inflammation/Immunology Cancer
Sanggenon C, a flavonoid, exerts protective effects against cardiac hypertrophy and fibrosis via suppression of the calcineurin/NFAT2 pathway. Sanggenon C inhibits mitochondrial fission to induce apoptosis by blocking the ERK signaling pathway. Sanggenon C inhibits inducible nitric oxide synthase expression in RAW264.7 cells, and TNF-α-stimulated cell adhesion and VCAM-1 expression, by suppressing NF-κB activity. Sanggenon C possesses antioxidant, anti-inflammatory and antitumor activities .

HY-172208

PROTAC cGAS degrader-1	PROTACs Cyclic GMP-AMP Synthase	Inflammation/Immunology
PROTAC cGAS degrader-1 is a potent and selective cGAS PROTAC degrader, with DC₅₀ values of 0.9 μM and 4.6 μM in THP-1 and RAW 264.7 cells, respectively. PROTAC cGAS degrader-1 induces proteasome-mediated degradation of cGAS, inhibits the cGAS signaling pathway, and attenuates double-stranded DNA-induced activation of cGAS in human and mouse cells. PROTAC cGAS degrader-1 is applicable to research related to ulcerative colitis .

HY-N11058

Damnacanthol	Lipoxygenase NO Synthase	Inflammation/Immunology
Damnacanthol is a natural product that can be isolated from Damnacanthus major . Damnacanthol has anti-15-lipoxygenase activity and can inhibit nitric oxide production in LPS-activated macrophages RAW 264.7 cells .

HY-155751

HMGB1-IN-1	Interleukin Related TNF Receptor NOD-like Receptor (NLR)	Inflammation/Immunology
HMGB1-IN-1 (compound 6) displays strong NO inhibitory effect in RAW264.7 cells with IC₅₀ value of 15.9 ± 0.6 μM. HMGB1-IN-1 inhibit the HMGB1/NF-κB/NLRP3 pathway. HMGB1-IN-1 shows good anti-inflammatory activity and good anti-sepsis effects in kidney injury .

HY-N8559

Aloesone	Reactive Oxygen Species (ROS) Apoptosis	Inflammation/Immunology
Aloesone is a phenolic compound. Aloesone can inhibit the production of ROS, the release of NO, M1 polarization, and apoptosis in RAW264.7 cells stimulated by LPS (HY-D1056). Aloesone has anti-inflammatory and antioxidant activities .

HY-N9337

Amaroswerin	NO Synthase	Metabolic Disease Inflammation/Immunology Cancer
Amaroswerin is a bioactive secoiridoid glucoside from Swertia mussotii. Amaroswerin has anti-inflammatory, antidiabetic, antiviral, anticholinergic and immunomodulatory activities. Amaroswerin inhibits NO release with an IC₅₀ value of 5.42 μg/mL in RAW264.7 cells .

HY-124478

Ethyl gentisate Ethyl 2,5-dihydroxybenzoate	Phosphatase	Metabolic Disease
Ethyl gentisate (Ethyl 2,5-dihydroxybenzoate) is a dual modulator for cell differentiation, that enhances the osteogenic differentiation of human mesenchymal stem cells (hMSCs) and alkaline phosphatase activity, inhibits RANKL-activated osteoclastogenesis in RAW264.7 cells, and balances the bone remodeling process .

HY-W753791

(±)-Perillaldehyde	TNF Receptor JNK	Neurological Disease Inflammation/Immunology
(±)-Perillaldehyde has an antidepressant effect by modulating the olfactory nervous system in a mouse model of stress-induced depression. (±)-Perillaldehyde also has anti-inflammatory activity, inducing JNK activation in RAW264.7 cells and inhibiting the expression of TNF-α, with an IC₅₀ of 171.7 μM .

HY-W341547

3,4-Dihydro-6,7-isoquinolinediol	Adrenergic Receptor	Inflammation/Immunology
3,4-Dihydro-6,7-isoquinolinediol (compound 7) is a β2-AR agonist with an EC50 of 106.9 μM in CH-K1/GA1S cells. 3,4-Dihydro-6,7-isoquinolinediol can also inhibit the production of NO in mouse macrophage RAW 264.7 cells induced by lipopolysaccharide, showing anti-inflammatory activity .

HY-N4207

Cnidicin	Others	Others
Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-N13239

Dandelion Extract	Apoptosis	Inflammation/Immunology
Dandelion Extract is a dandelion extract, and its ingredients include: Flavone. Dandelion Extract can reduce LPS-induced inflammatory responses in RAW264.7 cells by regulating cell polarization and apoptosis. Dandelion Extract can also reduce CuSO₄-induced inflammatory response in zebrafish larvae. .

HY-N13160

Sanggenon F	NO Synthase	Metabolic Disease Inflammation/Immunology
Sanggenon F is a flavonoid compound derived from Morus alba var. multicaulis. It inhibits the differentiation of 3T3-L1 adipocytes and the production of nitric oxide (NO) in RAW264.7 cells induced by lipopolysaccharides (HY-D1056) and IFN-γ (IC₅₀ of 19 nM). Sanggenon F has potential application value in the fields of anti-inflammatory and metabolic diseases .

HY-N12394

Norwogonin-8-O-glucuronide	Reactive Oxygen Species (ROS) NO Synthase	Inflammation/Immunology
Norwogonin-8-O-glucuronide is a glucuronide that can be isolated from Scutellaria indica. Norwogonin-8-O-glucuronide has anti-inflammatory activity. Norwogonin-8-O-glucuronide is a flavone glycoside. Norwogonin-8-O-glucuronide inhibits NO production in macrophage RAW264.7 cells with an IC₅₀ above 30 μM .

HY-123789

T5342126 1 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology
T-5342126 is a toll-like receptor 4 (TLR4) antagonist. It reduces LPS-induced production of nitric oxide (NO) in RAW 264.7 cells (IC₅₀=27.8 μM), as well as decreases LPS-induced IL-8, TNF-α, and IL-6 production in isolated human whole blood (IC₅₀s=110.5, 315.6, and 318.4 μM, respectively). T-5342126 (82 mg/kg) reduces ethanol intake and the abundance of ionized calcium-binding adapter molecule 1 (Iba1), a marker of microglial activation, in the central nucleus of the amygdala in ethanol-dependent mice.

HY-N16172

Sanggenon B Sanggenone B	Others	Inflammation/Immunology
Sanggenon B (Sanggenone B) is a compound that can be extracted from mulberry trees and has an inhibitory effect on NO production in RAW264.7 cells stimulated by LPS (HY-D1056). Sanggenon B has anti-inflammatory activity .

HY-118816

11β-Prostaglandin F2α 11-epi PGF2α-EA; 11β-PGF2α-EA; 11β-Prostamide F2α	Drug Metabolite	Metabolic Disease
11β-Prostaglandin F2α ethanolamide (11β-PGF2α-EA) is the theoretical hepatic metabolite of PGD2-EA, produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues.1 AEA can be used directly by COX-2 and specific PG synthase to produce ethanolamide congeners of the classical PGs. PGD2-EA is formed in activated RAW 264.7 cells treated with AEA.

HY-N13175

Panaxcerol B	NO Synthase	Cancer
Panaxcerol B is a monogalactosyl monoacylglyceride, with an IC₅₀ of 59.4 μM for NO production in LPS-stimulated RAW264.7 cells .

HY-129151

Ganoderic acid C1	TNF Receptor	Inflammation/Immunology
Ganoderic acid C1, a natural compound that could be isolated from G. lucidum, suppresses TNF-α production by murine macrophages (RAW 264.7 cells) .

HY-N2838

Alismol	NO Synthase	Inflammation/Immunology
Alismol is a natural sesquiterpene. Alismol shows promising inhibitory effects on INF-γ-induced nitric oxide production in murine macrophage RAW264.7 cells .

HY-N2989

3-O-Acetyl-16α-hydroxydehydrotrametenolic acid	NO Synthase	Inflammation/Immunology
3-O-Acetyl-16α-hydroxydehydrotrametenolic acid, an anti-inflammatory triterpenoid, inhibits NO production and iNOS expression in LPS-stimulated Raw264.7 cells .

HY-N3211

N-cis-Feruloyl tyramine cis-N-(4-Hydroxyphenethyl) ferulamide; cis-N-Feruloyltyramine	NO Synthase	Inflammation/Immunology
N-cis-Feruloyl tyramine (cis-N-(4-Hydroxyphenethyl) ferulamide) is a natural phenolic compound, exhibits modest inhibitory activity on LPS-activated NO production in RAW 264.7 cells .

HY-N17678

(E)-Sinapoyl glucose Raphanusol B	Drug Derivative NO Synthase	Inflammation/Immunology
(E)-Sinapoyl glucose is an inflammatory pathway inhibitor. (E)-Sinapoyl glucose inhibits NO production in RAW 264.7 cells with an IC₅₀ value of 38.32 µM. (E)-Sinapoyl glucose is promising for research of inflammatory diseases .

HY-N15689

Dichotomine E	NO Synthase	Inflammation/Immunology
Dichotomine E is a β-carboline alkaloid that can be isolated from the root of Stellaria dichotoma var. lanceolata. Dichotomine E has anti-inflammatory property for the inhibition of NO production in LPS (HY-D1056)-treated RAW264.7 cells .

HY-N9866

Grasshopper ketone	Others	Inflammation/Immunology
It is a bioactive compound with anti-inflammatory activity that inhibits LPS-induced NO production in RAW 264.7 cells and acts by inhibiting the phosphorylation of MAPK (ERK, JNK and p38) and NF-κB p65. Grasshopper ketone, as an ingredient, has shown its potential in anti-inflammatory inhibition .

HY-N11657

Sanggenon A Sanggenone A	NF-κB Keap1-Nrf2	Inflammation/Immunology
Sanggenon A (Sanggenone A) exerts anti-inflammatory effects by regulating NF-κB and HO-1/Nrf2 signaling pathways in BV2 and RAW264.7 cells. Sanggenon A markedly inhibits the Lipopolysaccharide (LPS; HY-D1056)-induced production of nitric oxide .

HY-N12042

Taxamairin B	TNF Receptor PI3K Reactive Oxygen Species (ROS) Interleukin Related	Inflammation/Immunology
Taxamairin B is a potent anti-inflammatory agent. Taxamairin B decreases proinflammatory cytokines (TNF-α, IL-1β and IL-6) expression and the production of NO and ROS in LPS-induced RAW264.7 cells. Taxamairin B exhibits significant protective effects in LPS-induced acute lung injury in mice .

HY-172977

FGA139	Cathepsin NO Synthase TNF Receptor	Neurological Disease Inflammation/Immunology
FGA139 is a cysteine proteases inhibitor with IC₅₀ values of 4.98/3.14 μM for cathepsin B/L. FGA139 reduces LPS-induced NO production in RAW264.7 cells and tumor necrosis factor (TNFα) levels in microglia, and has anti-oxidative stress and anti-inflammatory activities. FGA139 promotes the secretion of neuroprotective metabolites purine and linoleic acid by LPS-stimulated microglia. FGA139 can be used in neuroinflammatory diseases research .

HY-N8132

2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside	Reactive Oxygen Species (ROS)	Inflammation/Immunology
2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside is a chlorophenyl glycoside found in the bulbs of Lilium brownie var. viridulum. 2,4,6-Trichlorol-3-methyl-5-methoxy-phenol 1-O-β-d-glucopyranosyl-(1 → 6)-β-d-glucopyranoside exhibits weak inhibition of NO production in LPS-stimulated RAW 264.7 cells .

HY-N6636R

Valencene (Standard)	Reference Standards NF-κB Interleukin Related	Inflammation/Immunology
Valencene (Standard) is the analytical standard of Valencene. This product is intended for research and analytical applications. Valencene is a sesquiterpene that can be isolated from Cyperus rotundus. Valencene possesses antiallergic, antimelanogenesis, anti-infammatory, and antioxidant activitivies. Valencene inhibits the exaggerated expression of Th2 chemokines and proinflammatory chemokines through blockade of the NF-κB pathway. Valencene inhibits the production and expression of proinflammatory cytokines IL-1β and IL-6 in LPS-stimulated RAW 264.7 cells. Valencene can reduce atopic dermatitis symptoms and recover decreased expression of filaggrin in DNCB-sensitized mouse model .

HY-W573700

Methyl everninate	Others	Others
Methyl everninate is the major constituent of the deuterochloroform. Methyl everninate, rhodomollosides A and B are the derivatives of Methyl everninate, with cytotoxicity against RAW264.7 cells. Both of they shows inhibitory effects with a lipopolysaccharide (LPS)-stimulated murine macrophages RAW 264.7 cells model .

HY-N10120

Methylsyringin	Others	Inflammation/Immunology
Methylsyringin exhibits anti-inflammatory activity in the LPS-stimulated RAW264.7 cells.

HY-N3392

Lethedoside A	NO Synthase	Inflammation/Immunology
Lethedoside A is a natural flavonoid that shows inhibitory activity for LPS-induced NO production in RAW 264.7 cells .

HY-N9896

Anhydronotoptol	NO Synthase	Inflammation/Immunology
Anhydronotoptol is a potent nitric oxide inhibitory coumarin. Anhydronotoptol inhibits NO production in RAW 264.7 cells induced by LPS with an IC₅₀ value of 36.6 μM .

HY-139844

Anti-inflammatory agent 7	p38 MAPK NF-κB	Inflammation/Immunology
Anti-inflammatory agent 7 inhibits proinflammatory cytokines by blocking the NF-κB/MAPK signaling pathway in LPS-treated RAW 264.7 cells as well as mice.

HY-130787

Apterin	NO Synthase	Inflammation/Immunology
Apterin is a natural compound with anti-inflammatory activity. Apterin shows significantly inhibitory activity on NO production in RAW264.7 cells with an IC₅₀ value of 41.8 μM .

HY-N10062

Amakusamine	RANKL/RANK	Others
Amakusamine inhibits the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC₅₀ value of 10.5 μM in RAW264.7 cells.

HY-N1080

Vitexdoin A	Others	Inflammation/Immunology
Vitexdoin A is a nitric oxide scavenging lignin. Vitexdoin A inhibits NO production with an IC₅₀ of 0.38 μM in LPS (HY-D1056)-stimulated RAW 264.7 cells .

HY-161043

ECDD-S16	Pyroptosis	Inflammation/Immunology
ECDD-S16 is a potent inhibitor of pyroptosis. ECDD-S16 inhibits surface and endosomal TLR ligands activated pyroptosis in Raw264.7 cells .

HY-N9891

12-Dehydrogingerdione 12-DHGD	NO Synthase Interleukin Related	Inflammation/Immunology
12-Dehydrogingerdione is an inhibitor of NO Synthase. 12-Dehydrogingerdione signi?cantly inhibits LPS-stimulated production of NO, IL-6 and PGE2 in Raw 264.7 cells .

HY-N4207R

Cnidicin (Standard)	Reference Standards Others	Others
Cnidicin (Standard) is the analytical standard of Cnidicin. This product is intended for research and analytical applications. Cnidicin, a coumarin, inhibits the degranulation of mast cell and the nitric oxide (NO) generation in RAW 264.7 cells .

HY-N1494

(+)-14-Deoxy-ε-caesalpin 14-Deoxy-ε-caesalpin	NO Synthase	Inflammation/Immunology
(+)-14-Deoxy-ε-caesalpin (14-Deoxy-ε-caesalpin), a cassane diterpenoid, inhibits nitric oxide (NO) production release of RAW 264.7 cells stimulated by Lipopolysaccharide (LPS) .

HY-149647

HD-2a	JAK STAT	Inflammation/Immunology
HA-2a can inhibit the JAK2/STAT3 pathway via downregulates circDcbld2 expression in RAW264.7 cells .

HY-N2794

9-Hydroxy-α-lapachone α-Dihydrocaryopterone	NO Synthase	Inflammation/Immunology
9-Hydroxy-α-lapachone (α-Dihydrocaryopterone) is a natural phenol, exhibits potent inhibitory effects with an IC₅₀ of 4.64 µM on LPS-induced NO production in RAW 264.7 cells .

HY-N15571

Hedopeptolide	NO Synthase	Inflammation/Immunology
Hedopeptolide can be found in the marine cyanobacteria Okeania sp. Hedopeptolide inhibits LSP-induced NO production in RAW264.7 cells (IC₅₀: 4 μM). Hedopeptolide exhibits anti-inflammatory activity .

HY-N1695

Demethylregelin Regelin acid	NO Synthase	Inflammation/Immunology
Demethylregelin (Regelin acid), a triterpene, effectively reduces the expression of iNOS protein and subsequent nitric oxide production induced by lipopolysaccharide (HY-D1056) in RAW264.7 cells. Demethylregelin has anti-inflammatory activities .

HY-N12429

Marstenacisside F1	Others	Inflammation/Immunology
Marstenacisside F1 (compound 1) is a polyoxypregnanoside with anti-inflammatory activity isolated from Marsdenia tenacissima. Marstenacisside F1 inhibits lipopolysaccharide-induced nitric oxide (NO) production in RAW 264.7 cells and is a derivative of Tenacigenin B.

Cat. No.	Product Name	Target	Research Area

HY-P11183

Cathelicidin-PY	Bacterial Toll-like Receptor (TLR) TNF Receptor Interleukin Related JNK NF-κB	Infection Inflammation/Immunology
Cathelicidin-PY is an antimicrobial peptide exhibiting strong antimicrobial property. Cathelicidin-PY inhibits the activation of TLR4 inflammatory response pathways induced by lipopolysaccharide (LPS) (HY-D1056). Cathelicidin-PY possesses strong antimicrobial and anti-inflammatory activities and low cytotoxic ability against RAW 264.7 cells. Cathelicidin-PY can be used for antimicrobial and anti-inflammatory research .

Cat. No.	Product Name		Classification

HY-176126

STING agonist-42		Alkynes
STING agonist-42 (compound 8a) is a potent STING agonist. STING agonist-42 activates STING in THP1 and RAW 264.7 cells with EC₅₀s of 0.06 and 14.15 μM, respectively .

HY-173115

15-LOX-IN-2		Alkynes
15-LOX-IN-2 (Compound 2a) is an orally active COX-2/15-LOX inhibitor and a partial agonist of PPARγ. 15-LOX-IN-2 has anti-inflammatory activity and inhibits the levels of 20-HETE, IL-1β and TNF-α in RAW 264.7 cells treated with LPS (HY-D1056). In addition, 15-LOX-IN-2 has significant glucose uptake capacity in the absence of insulin. 15-LOX-IN-2 can be used for the research of metabolic diseases .

HY-159564

iNOS/COX-2-IN-3		Azide
iNOS/COX-2-IN-3 (compound 7d) is a dual inhibitor of iNOS and COX-2, with potential anti-inflammatory activity against LPS (HY-D1056)-induced RAW 264.7 cells (IC₅₀=3.48 μM). iNOS/COX-2-IN-3 has good plasma stability, oral activity and gastric safety, and its inhibitory activity on iNOS and COX-2 expression is 5.43-fold and 2.37-fold that of Indomethacin (HY-14397), respectively .

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RAW264.7+cells

Inhibitors & Agonists

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NaturalProducts

Click Chemistry

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