Asperflavin
Asperflavin is an anti-inflammatory compound that can be produced by the marine fungus Eurotium amstelodami. Asperflavin inhibits the production of NO, PGE2, and proinflammatory cytokines, as well as the expression of inducible NOS (iNOS) in RAW 264.7 cells treated with LPS (HY-D1056). Asperflavin can be used in the study of inflammatory diseases.
For research use only. We do not sell to patients.
- CAS No.: 1415764-41-8
- Formula: C16H16O5
- Molecular Weight:288.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
|
iNOS |
IL-6 |
IL-1β |
TNF-α |
Asperflavin (0- 200 μM, 24 h) does not alter cell viability of LPS-treated RAW 264.7 cells[1].
Asperflavin (0-200 μM, 24 h) inhibits the production of NO and PGE2 in LPS-treated RAW 264.7 cells[1].
Asperflavin (0-200 μM, 24 h) inhibits the expression of iNOS in LPS-treated RAW 264.7 cells, but does not reduce the expression of COX-2[1].
Asperflavin (0-200 μM, 24 h) reduces the expression of TNF-α, IL-1β and IL-6 in LPS-treated RAW 264.7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LPS-Stimulated (1 μg/mL) RAW 264.7 cells
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Concentration:50 μM, 100 μM, 200 μM
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Incubation Time:24 h
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Result:Inhibited the expression of iNOS but did not reduce the expression of COX-2.
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Cell Line:LPS-Stimulated (1 μg/mL) RAW 264.7 cells
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Concentration:50 μM, 100 μM, 200 μM
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Incubation Time:24 h
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Result:Reduced the production of TNF-α, IL-1β, and IL-6 at a concentration of 200 μM.
Reduced TNF-α, IL-6 levels without changing IL-1β levels at concentrations of 100 μM.
Reduced the production of TNF-α, did not change IL-1β, IL-6 production at a concentration of 50 μM.
Chemical Information
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CAS No. 1415764-41-8
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Molecular Weight 288.30
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Formula C16H16O5
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SMILES
OC1=C2C(C[C@](O)(CC2=O)C)=CC3=CC(O)=CC(OC)=C31
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Structure Classification
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Initial Source
Aspergillus sp. EGF15-0-3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Asperflavin Related Classifications
HY-N15651 Related Classifications
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