Stat3 - signal transducer and activator of transcription 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25125

About Stat3

Primary_assembly 10: 85,811,218-85,863,057 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 133 orthologues, 5 paralogues and is associated with 125 phenotypes. Biased expression in Heart (RPKM 347.1), Lung (RPKM 285.5) and 9 other tissues.

Summary

Enables CCR5 Chemokine Receptor binding activity; Glucocorticoid Receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of interleukin-6 production; and regulation of cellular biosynthetic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in mitochondrial inner membrane and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Biomarker of colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent Infection syndrome 1; reproductive organ Cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Apr 2022]

Stat3 Products (2)

mRNA Protein Name
NM_012747.2 NP_036879.1 signal transducer and activator of transcription 3
NM_012747.2 NP_036879.1 signal transducer and activator of transcription 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CCR5 chemokine receptor binding IPI
IPI: Inferred from physical interaction
14674010 RGD
enables DNA binding IDA
IDA: Inferred from direct assay
8530402 RGD
enables DNA-binding transcription factor binding IPI
IPI: Inferred from physical interaction
16527988 RGD
enables nuclear glucocorticoid receptor binding IPI
IPI: Inferred from physical interaction
20155810 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16055727 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16648019 RGD
Biological Process GO Annotation Evidence References Source
involved in acute-phase response IEP
IEP: Inferred from expression pattern
8530402 RGD
acts upstream of or within cellular response to cytokine stimulus IDA
IDA: Inferred from direct assay
19414010 RGD
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19414010 RGD
involved in modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
22284190 RGD
involved in modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
22284190 RGD
involved in modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
22284190 RGD
involved in negative regulation of hydrogen peroxide biosynthetic process IMP
IMP: Inferred from mutant phenotype
23590160 RGD
involved in positive regulation of ATP biosynthetic process IMP
IMP: Inferred from mutant phenotype
23590160 RGD
involved in positive regulation of canonical NF-kappaB signal transduction IGI
IGI: Inferred from genetic interaction
29702085 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
23608221 RGD
involved in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation IMP
IMP: Inferred from mutant phenotype
23869758 RGD
acts upstream of positive regulation of interleukin-6 production IGI
IGI: Inferred from genetic interaction
29702085 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19538478 RGD
involved in postsynapse to nucleus signaling pathway IDA
IDA: Inferred from direct assay
22284190 RGD
involved in postsynapse to nucleus signaling pathway IEP
IEP: Inferred from expression pattern
22284190 RGD
involved in regulation of cellular response to hypoxia IMP
IMP: Inferred from mutant phenotype
19450559 RGD
involved in regulation of mitochondrial membrane permeability IMP
IMP: Inferred from mutant phenotype
23590160 RGD
involved in response to cytokine IDA
IDA: Inferred from direct assay
18270592 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17916759 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17916759 RGD
involved in response to ischemia IMP
IMP: Inferred from mutant phenotype
23884942 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
18339648 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
17911393 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18031608 RGD
Cellular Component GO Annotation Evidence References Source
is active in Schaffer collateral - CA1 synapse EXP
EXP: Inferred from Experiment
22284190 RGD
is active in Schaffer collateral - CA1 synapse IDA
IDA: Inferred from direct assay
22284190 RGD
is active in Schaffer collateral - CA1 synapse IMP
IMP: Inferred from mutant phenotype
22284190 RGD
located in cytosol IDA
IDA: Inferred from direct assay
23884942 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
22284190 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22284190 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22284190 RGD
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
23271731 RGD
located in nucleus IDA
IDA: Inferred from direct assay
19538478 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
10891587 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Stat3 Protein Structure

STAT_int

STAT_int: smart00964 (1 - 119)

STAT3_CCD

STAT3_CCD: cd16853 (138 - 317)

STAT3_DBD

STAT3_DBD: cd16847 (320 - 483)

SH2_STAT3

SH2_STAT3: cd10374 (553 - 714)

  • 0
  • 200
  • 400
  • 600
  • 770 a.a.
Protein Preferred Names Protein Names

signal transducer and activator of transcription 3

  • signal transducer and activator of transcription 3 (acute-phase response factor)

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10201 Sorafenib Inhibitor 99.85% Yes
HY-117287 Deucravacitinib Inhibitor 99.93% Unkown
HY-N0193 Artesunate Inhibitor 99.89% Yes
HY-14944 Homoharringtonine Inhibitor 99.96% Yes
HY-B0497 Niclosamide Inhibitor 99.96% Yes
HY-B2163 Astaxanthin Inhibitor 98.0% Unkown
HY-100754 Ritlecitinib Inhibitor 99.80% Yes
HY-12987 Pimozide Inhibitor 99.94% Yes
HY-10201A Sorafenib tosylate Inhibitor 99.98% Yes
HY-B0130 Perindopril 99.85% Yes
HY-17015A Peramivir 99.94% Unkown
HY-B1436 Nifuroxazide Inhibitor 99.90% Unkown
HY-B0294 Flubendazole Inhibitor 99.05% Yes
HY-15728 Radotinib Inhibitor 99.19% Yes
HY-B0130A Perindopril erbumine 99.98% Yes
HY-B0667 Balsalazide Inhibitor 98.65% Yes
HY-B0667A Balsalazide sodium hydrate Inhibitor 98.30% Yes
HY-100754C Ritlecitinib tosylate Inhibitor 99.65% Yes
HY-112961 Patiromer Inhibitor 95.0% Unkown
HY-B0497B Niclosamide monohydrate Inhibitor / Unkown
HY-100754A Ritlecitinib malonate Inhibitor / Unkown
HY-108244 Balsalazide disodium Inhibitor / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9916 Sarilumab Inhibitor 99.36% Unkown
HY-P99118 Serplulimab Inducer 99.30% Unkown

Clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name Effect
Purity Phase
HY-12987S Pimozide-d4 Inhibitor 99.2% Phase 4
HY-16141 Cilengitide Inhibitor 99.91% Phase 3
HY-13919 Napabucasin Inhibitor 99.94% Phase 3
HY-112288 C188-9 Inhibitor 99.84% Phase 2
HY-15312 WP1066 Inhibitor 99.53% Phase 2
HY-136657 SC-43 Inhibitor 99.01% Phase 2
HY-165386 TU-100 Inhibitor / Phase 2
HY-14743A Golotimod TFA Inhibitor / Phase 2
HY-156730 KT-333 Degrader 98.91% Phase 1
HY-13326 ASP3026 99.88% Phase 1
HY-16196 ENMD-1198 Inhibitor 98.87% Phase 1
HY-124067 EC-70124 Inhibitor / Phase 1
HY-164425 ENT-03 Activator / Phase 1
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99210 Olokizumab Inhibitor 99.54% Phase 3
HY-P99244 Fezakinumab Modulator 99.9% Phase 2
HY-P991888 INCA033989 Inhibitor 98.12% Phase 1

Pre-clinical Phase

Bioactive Molecules (261)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13818 Stattic Inhibitor 99.96% Unkown
HY-107632 GYY4137 Inhibitor 98.64% Unkown
HY-12000 AG490 Inhibitor 99.86% Unkown
HY-P1061 Colivelin Activator 99.92% Unkown
HY-10074 TPCA-1 Inhibitor 99.66% Unkown
HY-15146 NSC 74859 Inhibitor 98.35% Unkown
HY-N0751 Scutellarin Inhibitor 99.57% Unkown
HY-N0174 Cryptotanshinone Inhibitor 99.07% Unkown
HY-148748 Butyzamide Activator 99.83% Unkown
HY-129602 SD-36 Inhibitor 99.73% Unkown
HY-N0177 Diosgenin Inhibitor 99.92% Unkown
HY-N0250 Saikosaponin D Inhibitor 99.81% Unkown
HY-125771 1-Stearoyl-sn-glycero-3-phosphocholine Inhibitor 99.53% Unkown
HY-P1061A Colivelin TFA Activator 99.79% Unkown
HY-111152 ML115 Agonist 99.98% Unkown
HY-N0622 Morusin Inhibitor 99.54% Unkown
HY-129603 SI-109 Inhibitor 99.91% Unkown
HY-16975 SH-4-54 Inhibitor 99.80% Unkown
HY-N1405 Cucurbitacin I Inhibitor 99.60% Unkown
HY-100493 BP-1-102 Inhibitor 99.26% Unkown
HY-100753 STAT3-IN-1 Inhibitor 96.28% Unkown
HY-113066C Guanosine 5'-diphosphate sodium, 96% (HPLC) Inhibitor 99.88% Unkown
HY-115594 Erasin Inhibitor 96.02% Unkown
HY-N0038 Alantolactone Inhibitor 99.94% Unkown
HY-173236 STAT4-IN-1 Inhibitor 99.17% Unkown
HY-N0202 Atractylenolide II Inhibitor 99.89% Unkown
HY-170621 STAT1/3-IN-1 Inhibitor 99.23% Unkown
HY-N2959 Brevilin A Inhibitor 99.86% Unkown
HY-128588 STAT3-IN-3 Inhibitor 98.40% Unkown
HY-N0826 Corynoline Modulator 98.84% Unkown
HY-113205 15-keto-Prostaglandin E2 Inhibitor ≥99.0% Unkown
HY-19536 LLL12 Inhibitor 99.45% Unkown
HY-160496 STAT3-IN-25 Inhibitor 99.36% Unkown
HY-103692 STX-0119 Inhibitor 98.40% Unkown
HY-100602 HJC0152 Inhibitor 99.75% Unkown
HY-121983 CAY10594 Inhibitor 98.64% Unkown
HY-135457 JMS-053 Inhibitor 98.0% Unkown
HY-100453 HO-3867 Inhibitor 99.67% Unkown
HY-N6954 Garcinone C Inhibitor 99.51% Unkown
HY-N0735 Phellodendrine chloride Inhibitor 99.68% Unkown
HY-N2312 Mogrol Inhibitor 99.76% Unkown
HY-N2116 Ginkgolic acid C17:1 Inhibitor 99.80% Unkown
HY-P1615 Cenupatide Inhibitor 99.94% Unkown
HY-122258 NSC-370284 Inhibitor 99.27% Unkown
HY-N0885 Telocinobufagin Inhibitor 99.93% Unkown
HY-N2963 Broussonin E Activator 98.11% Unkown
HY-148692 OSM-SMI-10B Inhibitor 99.70% Unkown
HY-113573 Protosappanin A 99.95% Unkown
HY-N6953 Garcinone D Activator 99.30% Unkown
HY-N2521 Tetramethylcurcumin Inhibitor 99.91% Unkown
HY-103128 inS3-54A18 Inhibitor 99.93% Unkown
HY-N0897 Corylifol A Inhibitor 99.90% Unkown
HY-169360 SD-436 Degrader 98.27% Unkown
HY-129125 YMU1 Activator 99.19% Unkown
HY-N1356 Reticuline Inhibitor 98.89% Unkown
HY-158142 PROTAC TYK2 degrader-1 Inhibitor 99.55% Unkown
HY-N6711 Equisetin Inhibitor 99.40% Unkown
HY-150538 STAT3-IN-12 Inhibitor 99.87% Unkown
HY-P10201A Ac-GpYLPQTV-NH2 acetate Inhibitor 99.00% Unkown
HY-N0918 Desmethoxyyangonin Inhibitor 99.00% Unkown
HY-P10953 Fulipiftide Activator 99.38% Unkown
HY-12538 Graveoline Inhibitor 99.93% Unkown
HY-164546 WB436B Inhibitor 99.93% Unkown
HY-129138 Cyanidin 3,5-diglucoside chloride Inhibitor 99.44% Unkown
HY-N1410 Triacetylresveratrol Inhibitor 99.11% Unkown
HY-18061 Ochromycinone Inhibitor 99.61% Unkown
HY-12352A HJC0416 hydrochloride Inhibitor 98.68% Unkown
HY-14743B Golotimod hydrochloride Inhibitor 99.79% Unkown
HY-156466 QL-1200186 Inhibitor 99.95% Unkown
HY-N9561 Vanicoside B Inhibitor 99.82% Unkown
HY-N7064 Iminostilbene Inhibitor 99.66% Unkown
HY-151976 STAT3-IN-15 Inhibitor 98.99% Unkown
HY-136658 STAT3-IN-48 Inhibitor 98.64% Unkown
HY-N1407 Polygalaxanthone III Activator 99.28% Unkown
HY-N7695 Physalin B Inhibitor 97.20% Unkown
HY-124858 SC99 Inhibitor 98.90% Unkown
HY-P5314 OK2 Inhibitor 99.13% Unkown
HY-N3239 Mulberrofuran G Inhibitor 97.86% Unkown
HY-N1988 Cucurbitacin IIa Activator 99.90% Unkown
HY-206870 BP79 Inhibitor / Unkown
HY-124686 ER-464195-01 Inhibitor 99.72% Unkown
HY-148706 STAT3-IN-17 Inhibitor 98.0% Unkown
HY-179715 PROTAC JAK1/2 degrader-1 Inhibitor 99.47% Unkown
HY-125771S 1-Stearoyl-sn-glycero-3-phosphocholine-d35 Inhibitor 99% Unkown
HY-163502 PROTAC STAT3 degrader-3 Degrader 99.75% Unkown
HY-120395 UC-514321 Inhibitor 98.0% Unkown
HY-147187 MNK8 Inhibitor 99.76% Unkown
HY-N2000 Bellidifolin Modulator 99.74% Unkown
HY-119487 MMPP Inhibitor 99.31% Unkown
HY-163526 STAT3-IN-26 96.84% Unkown
HY-100610 S3I-1757 Inhibitor 99.51% Unkown
HY-N7653 Azaleatin Inhibitor 98.86% Unkown
HY-163176 WB518 Inhibitor 96.48% Unkown
HY-N0143A Phlorizin dihydrate Antagonist 99.51% Unkown
HY-P2282 APTSTAT3-9R Inhibitor 98.82% Unkown
HY-122949 Momordicine I Inhibitor 97.0% Unkown
HY-100494 SH5-07 Inhibitor 98.0% Unkown
HY-120692 Cyclanoline chloride Inhibitor 96.27% Unkown
HY-N0427 Phellodendrine Inhibitor 99.60% Unkown
HY-112391 SD-1029 Inhibitor 88.8% Unkown
HY-125170 Galiellalactone Inhibitor 99% Unkown
HY-172946 SD-2301 Degrader 99.89% Unkown
HY-113509B 15(R)-Lipoxin A4 Inhibitor 98.3% Unkown
HY-N8389 Globulol Inhibitor 99.74% Unkown
HY-156730A KT-333 ammonium Degrader 99.48% Unkown
HY-109038 Mocravimod Activator 98.39% Yes
HY-150251 SD-91 Degrader 97.49% Unkown
HY-14743 Golotimod Inhibitor 98.98% Unkown
HY-113066 Guanosine 5'-diphosphate Inhibitor / Unkown
HY-172767 STAT3-D11-PROTAC-VHL Degrader 96.33% Unkown
HY-177990 STAT3-IN-52 Inhibitor / Unkown
HY-P10201 Ac-GpYLPQTV-NH2 Inhibitor 99.38% Unkown
HY-169908 STAT3-IN-37 Inhibitor / Unkown
HY-178821 ROCK2-IN-12 Inhibitor 98.02% Unkown
HY-N6651 Isocryptotanshinone Inhibitor ≥98.0% Unkown
HY-125542 DCZ3301 Inhibitor 99.73% Unkown
HY-N2240 Eupalinolide K Inhibitor 99.20% Unkown
HY-117511 HJC0123 Inhibitor 99.06% Unkown
HY-N8840 Laricitrin Inhibitor 99.36% Unkown
HY-107595 SD-1008 Inhibitor 99.10% Unkown
HY-182359 YYSW001 Inhibitor / Unkown
HY-156730B KT-333 diammonium Degrader / Unkown
HY-144871 STAT3-IN-8 Inhibitor / Unkown
HY-W717425 SC-60 Inhibitor / Unkown
HY-183670 JAK2-IN-21 Inhibitor / Unkown
HY-175634 ALOX5 stabilizer-1 Inhibitor / Unkown
HY-180795 PKM2 activator 11 Inhibitor / Unkown
HY-129341 WP1193 Inhibitor / Unkown
HY-115438 AUH-6-96 Inhibitor / Unkown
HY-115541 BRD4-IN-41 / Unkown
HY-184162 HSP110-IN-1 Inhibitor / Unkown
HY-170947 Antitumor agent-195 Inhibitor / Unkown
HY-149257 HAT-SIL-TG-1&AT Inhibitor / Unkown
HY-162885 YSY01A Inhibitor / Unkown
HY-175010 STAT3-IN-44 Inhibitor / Unkown
HY-122759 CPA-7 Inhibitor / Unkown
HY-184419 YZZ-24 Inhibitor / Unkown
HY-168178 Hsp110-STAT3 PPI-IN-2 Inhibitor / Unkown
HY-181514 STAT3-IN-53 Inhibitor / Unkown
HY-N16557 (Rac)-8-Gingerol Inhibitor / Unkown
HY-131559 N-Deacetyl-SI-109-(OEt)2 / Unkown
HY-182273 DM243 Modulator / Unkown
HY-175848 NSC 850745 Inhibitor / Unkown
HY-175771 STAT3-IN-46 Inhibitor / Unkown
HY-146666 STAT3-IN-9 Inhibitor / Unkown
HY-146728 STAT3-IN-10 Inhibitor / Unkown
HY-187212 SH-17 Inhibitor / Unkown
HY-151286 Antitumor agent-73 Inhibitor / Unkown
HY-170977 JAK1/STAT3-IN-1 Inhibitor / Unkown
HY-184731 AH-26 Inhibitor / Unkown
HY-174457 STAT3/CAIX-IN-1 Inhibitor / Unkown
HY-175298 STAT-3/c-Src-IN-1 Inhibitor / Unkown
HY-182922 SD-965 Degrader / Unkown
HY-N20711 Usenamine A Inhibitor / Unkown
HY-175009 MRC-G-001 Inhibitor / Unkown
HY-177990A STAT3-IN-52 hydrochloride Inhibitor 96.42% Unkown
HY-181773 P-gp-IN-36 Inhibitor / Unkown
HY-149700 ROCK2-IN-7 / Unkown
HY-181783 CHI3L1-IN-7 Inhibitor / Unkown
HY-180226 Apoptosis inducer 55 Inhibitor / Unkown
HY-12292G IM-12 (GMP) Inhibitor / Unkown
HY-164216A (trans)-STAT6-IN-13 Modulator / Unkown
HY-N13338 Avicin D Inhibitor / Unkown
HY-184736 STAT3/NF-κB-IN-3 Inhibitor / Unkown
HY-N13294 Cernuumolide J Inhibitor / Unkown
HY-179468 STAT3-IN-49 Inhibitor / Unkown
HY-N0390G L-Glutamine (GMP) Inhibitor / Unkown
HY-174988 JAK2-IN-13 Inhibitor / Unkown
HY-169403 NW16 Inhibitor / Unkown
HY-159570 XD2-149 Inhibitor / Unkown
HY-174386 STAT3-IN-43 Inhibitor / Unkown
HY-101021 Ascochlorin Inhibitor / Unkown
HY-164445 STAT3-IN-32 Inhibitor / Unkown
HY-155746 JAK2-IN-9 Inhibitor / Unkown
HY-13752 STA-1474 Inhibitor / Unkown
HY-180245 STAT3-IN-51 Inhibitor / Unkown
HY-168893 K882 Inhibitor / Unkown
HY-113205S 15-Keto-prostaglandin E2-d9 Inhibitor / Unkown
HY-175013 CDK6/9-IN-2 Inhibitor / Unkown
HY-125718 MLS-2384 free base / Unkown
HY-162803 c-Met-IN-24 Inhibitor / Unkown
HY-176535 KB-0118 Inhibitor / Unkown
HY-12352 HJC0416 Inhibitor / Unkown
HY-153023 PROTAC STAT3 degrader-2 Degrader / Unkown
HY-184692 NF-κB/STAT3/iNOS-IN-1 Inhibitor / Unkown
HY-126420 Kansuinine B Inhibitor 99.0% Unkown
HY-N11501 7-epi-Isogarcinol Inhibitor / Unkown
HY-184891 W1307 Inhibitor / Unkown
HY-175781 CHI3L1-IN-4 Inhibitor / Unkown
HY-112447 STAT3-IN-5 Inhibitor / Unkown
HY-180117 MMP-2/9-IN-2 Inhibitor / Unkown
HY-N13352 Bufothionine Inhibitor / Unkown
HY-174428 PROTAC JAK2 degrader-1 Inhibitor / Unkown
HY-182288 YN11 Inhibitor / Unkown
HY-182510 NTZ-24 Inhibitor / Unkown
HY-179243 S3D5 Degrader / Unkown
HY-161864 STAT3-IN-29 Inhibitor / Unkown
HY-176876 Glucocorticoid receptor/IL-6-IN-1 Inhibitor / Unkown
HY-150895 SI-191 Ligand / Unkown
HY-164533 STAT3-IN-33 Inhibitor / Unkown
HY-180922 EGFR kinase-IN-8 Inhibitor / Unkown
HY-184706 SHN7 Inhibitor / Unkown
HY-169797 STAT3-IN-38 Inhibitor / Unkown
HY-138071 8α-Tigloyloxyhirsutinolide 13-O-acetate Inhibitor 95.0% Unkown
HY-153858 PHI-501 Inhibitor / Unkown
HY-175320 PROTAC c-Met degrader-5 Inhibitor / Unkown
HY-164216 STAT6-IN-13 Inhibitor / Unkown
HY-178140 STAT3-IN-47 Inhibitor / Unkown
HY-180956 PROTAC ALK degrader-5 Inhibitor / Unkown
HY-183783 PROTAC RET Degrader 2 Inhibitor / Unkown
HY-169370 STAT3 HiBiT degrader 1 Degrader / Unkown
HY-170946 WR-S-462 Inhibitor / Unkown
HY-184149 ROCK2-IN-17 / Unkown
HY-168903 STAT3-IN-41 Inhibitor / Unkown
HY-176555 Z169667518 Inhibitor / Unkown
HY-183143 Lss-11 Inhibitor / Unkown
HY-161351 STAT3/AKT-IN-1 Inhibitor / Unkown
HY-183307 mTOR-IN-29 / Unkown
HY-182274 DM245 Inhibitor / Unkown
HY-184119 Pabgraminone C Modulator / Unkown
HY-182380 ODZ10117 Inhibitor / Unkown
HY-168551 PROTAC ALK degrader-3 Inhibitor / Unkown
HY-183272 PI3K/Akt/mTOR-IN-7 Inhibitor / Unkown
HY-187011 STAT3 ligand 7 Ligand / Unkown
HY-N3913 Furowanin A Inhibitor / Unkown
HY-180937 CHI3L1-IN-6 Inhibitor / Unkown
HY-161859 VEGFR-2/STAT-3-IN-1 Inhibitor / Unkown
HY-181872 JAK1-IN-20 Inhibitor / Unkown
HY-181587 PDGFRA/CAIX/XII-IN-1 Inhibitor 98.10% Unkown
HY-183370 JAK2/STAT3-IN-2 Inhibitor / Unkown
HY-171656 G721-0282 Inhibitor 99.96% Unkown
HY-N17494 Crispene E Inhibitor / Unkown
HY-159157 Anti-inflammatory agent 92 Inhibitor / Unkown
HY-184734 STAT3/NF-κB-IN-2 Inhibitor / Unkown
HY-175201 pro-FTY Inhibitor / Unkown
HY-175227 STAT3/NF-κB-IN-1 Inhibitor / Unkown
HY-120031 NSC-368262 Inhibitor / Unkown
HY-183628 MEAP Modulator / Unkown
HY-186227 ISS840 Inhibitor / Unkown
HY-184833 Tyk2-IN-25 Inhibitor / Unkown
HY-N20636 7α-Morroniside Inhibitor / Unkown
HY-N8098 Pulchinenoside E2 Inhibitor 99.28% Unkown
HY-107632G GYY4137 (GMP) Inhibitor / Unkown
HY-124595 MPT0B098 / Unkown
HY-N16435 Plumericin Inhibitor / Unkown
HY-N4189 Isocucurbitacin B Inhibitor 98.98% Unkown
HY-153652 LC28 Inhibitor / Unkown
HY-113205S1 15-Keto-prostaglandin E2-d4 Inhibitor / Unkown
HY-183402 FLLL12 Inhibitor / Unkown
HY-13752B STA-1474 sodium Inhibitor / Unkown
HY-183519 AH057 / Unkown
HY-N18989 Cyclo(L-Ile-D-Leu) Inhibitor / Unkown
HY-N14323 Madindoline A Inhibitor / Unkown
HY-119009 TM-233 Inhibitor / Unkown
HY-N19899 Phaeosphaeride A Inhibitor / Unkown
HY-164521 PMMB-187 Inhibitor / Unkown
HY-N15201 Betavulgarin Inhibitor / Unkown
HY-123827 GPA512 Inhibitor / Unkown
HY-164473 DETD-35 Inhibitor / Unkown
HY-171038 STAT3-IN-39 Inhibitor / Unkown
HY-169361 STAT3 ligand 5 / Unkown
Inhibitory Antibodies (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991218 Anti-IL11 Antibody (X203) Inhibitor 98.53% Unkown
HY-P99143 Anti-Mouse NK1.1 Antibody (PK136) Inhibitor 98.57% Unkown
HY-P990212 Anti-Mouse IL-6 Antibody (MP5-20F3) Inhibitor 99.36% Unkown
HY-P990279 Anti-Mouse CD276/B7-H3 Antibody (MJ18) Inhibitor 95.00% Unkown
HY-P990294 Anti-Mouse CD106/VCAM-1 Antibody (M/K-2.7) Inhibitor 95.00% Unkown
HY-P99917 Eflepedocokin alfa Activator ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Stat3 NCBI NCBI:6774