2. Apoptosis Stem Cell/Wnt JAK/STAT Signaling
  3. Apoptosis STAT
  4. STAT3-IN-9

STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase.

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STAT3-IN-9 Chemical Structure

STAT3-IN-9 Chemical Structure

CAS No. : 2987726-27-0

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STAT3-IN-9 Related Antibodies

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Description

STAT3-IN-9 is a potent STAT3 inhibitor. STAT3-IN-9 inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701). STAT3-IN-9 induces apoptosis and cell cycle arrest at the G2/M phase[1].

IC50 & Target

STAT3

 

In Vitro

STAT3-IN-9 (compound C6) (48 h) shows potent in vitro anti-tumor activity with IC50s of 0.16, 5.80, 1.63, 5.73, >25, >25 µM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively[1].
STAT3-IN-9 (0, 0.2, 1.0, 5.0 µM; 24 h) inhibits the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701)[1].
STAT3-IN-9 (0, 0.2, 1 µM; 24 h) induces apoptosis through the mitochondrial Caspase dependent apoptotic pathway[1].
STAT3-IN-9 (0, 0.2, 1 µM; 24 h) induces cell cycle arrest at the G2/M phase in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3-IN-9 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells
Concentration:
Incubation Time: 48 h
Result: Showed potent in vitro anti-tumor activity with IC50s of 0.16, 5.80, 1.63, 5.73, >25, >25 µM for MDA-MB-468, MDA-MB-231, HepG2, A549, U251, HCT116 cells, respectively.

Western Blot Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0, 0.2, 1.0, 5.0 µM
Incubation Time: 24 h
Result: Inhibited the activation of STAT3 (Tyr705) without influencing the phosphorylation of STAT1 (Tyr701).

Apoptosis Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0, 0.2, 1 µM
Incubation Time: 24 h
Result: Induced apoptosis through the mitochondrial Caspase dependent apoptotic pathway.

Cell Cycle Analysis[1]

Cell Line: MDA-MB-468 cells
Concentration: 0, 0.2, 1 µM
Incubation Time: 24 h
Result: Cells were arrest at the G2/M phase in a dose-dependent manner.
Molecular Weight

391.42

Formula

C22H21N3O4
CAS No.
SMILES

COC1=CC(NC2=CC(C3=CC=NN3C)=CC4=C2OC(C(C)=O)=C4)=CC(OC)=C1
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Purity & Documentation
References
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STAT3-IN-9 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-92987726-27-0ApoptosisSTATMDA-MB-468 cellsapoptosisG2/Mphosphorylationanti-tumorconcentration-dependentInhibitorinhibitorinhibit

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