STAT3 - signal transducer and activator of transcription 3 Gene
Also Known as APRF; HIES; ADMIO; ADMIO1
Species: Homo sapiens
About STAT3
This gene has 50 transcripts (splice variants), 133 orthologues, 6 paralogues and is associated with 103 phenotypes. Ubiquitous expression in gall bladder (RPKM 47.5), lung (RPKM 47.3) and 25 other tissues.
Summary
The protein encoded by this gene is a member of the STAT protein family. In response to Cytokines and Growth Factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various Cytokines and Growth Factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and Apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and Bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020]
STAT3 Products (24)
| mRNA | Protein | Name |
|---|---|---|
| NM_001369512.1 | NP_001356441.1 | signal transducer and activator of transcription 3 isoform 1 |
| NM_001384986.1 | NP_001371915.1 | signal transducer and activator of transcription 3 isoform 7 |
| NM_003150.4 | NP_003141.2 | signal transducer and activator of transcription 3 isoform 2 |
| NM_001384985.1 | NP_001371914.1 | signal transducer and activator of transcription 3 isoform 6 |
| NM_001369514.1 | NP_001356443.1 | signal transducer and activator of transcription 3 isoform 2 |
| NM_001369517.1 | NP_001356446.1 | signal transducer and activator of transcription 3 isoform 3 |
| NM_001384989.1 | NP_001371918.1 | signal transducer and activator of transcription 3 isoform 10 |
| NM_001384992.1 | NP_001371921.1 | signal transducer and activator of transcription 3 isoform 13 |
| NM_001369520.1 | NP_001356449.1 | signal transducer and activator of transcription 3 isoform 4 |
| NM_001369519.1 | NP_001356448.1 | signal transducer and activator of transcription 3 isoform 4 |
| NM_001369516.1 | NP_001356445.1 | signal transducer and activator of transcription 3 isoform 2 |
| NM_001384990.1 | NP_001371919.1 | signal transducer and activator of transcription 3 isoform 11 |
| NM_001384993.1 | NP_001371922.1 | signal transducer and activator of transcription 3 isoform 14 |
| NM_001369518.1 | NP_001356447.1 | signal transducer and activator of transcription 3 isoform 3 |
| NM_001384984.1 | NP_001371913.1 | signal transducer and activator of transcription 3 isoform 5 |
| XM_047436586.1 | XP_047292542.1 | signal transducer and activator of transcription 3 isoform X3 |
| NM_001369513.1 | NP_001356442.1 | signal transducer and activator of transcription 3 isoform 1 |
| NM_213662.2 | NP_998827.1 | signal transducer and activator of transcription 3 isoform 3 |
| XM_047436585.1 | XP_047292541.1 | signal transducer and activator of transcription 3 isoform X1 |
| NM_001384987.1 | NP_001371916.1 | signal transducer and activator of transcription 3 isoform 8 |
| XM_017024973.3 | XP_016880462.1 | signal transducer and activator of transcription 3 isoform X2 |
| NM_139276.3 | NP_644805.1 | signal transducer and activator of transcription 3 isoform 1 |
| NM_001384988.1 | NP_001371917.1 | signal transducer and activator of transcription 3 isoform 9 |
| NM_001384991.1 | NP_001371920.1 | signal transducer and activator of transcription 3 isoform 12 |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| part of RNA polymerase II transcription regulator complex |
IMP
IMP: Inferred from mutant phenotype
|
16946298 | GOA |
| part of RNA polymerase II transcription regulator complex |
IPI
IPI: Inferred from physical interaction
|
8662591 | GOA |
| located in chromatin |
IDA
IDA: Inferred from direct assay
|
16835372 | GOA |
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
15653507 | GOA |
| is active in nucleus |
IDA
IDA: Inferred from direct assay
|
7528668 | GOA |
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
12444102 | GOA |
| part of transcription regulator complex |
IDA
IDA: Inferred from direct assay
|
24429361 | GOA |
STAT3 Protein Structure
STAT_int: STAT protein, protein interaction domain (2 - 121)
STAT_alpha: STAT protein, all-alpha domain (139 - 319)
STAT_bind: STAT protein, DNA binding domain (321 - 574)
SH2: SH2 domain (584 - 674)
- 0
- 200
- 400
- 600
- 770 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
signal transducer and activator of transcription 3 |
|
STAT3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
STAT3 | P40763 | CORO1A | Homo sapiens | P31146 | 21988832 | |
|
Intra
|
STAT3 | P40763 | BCKDK | Homo sapiens | O14874 | 21988832 | |
|
Intra
|
STAT3 | P40763 | STAT1 | Homo sapiens | P42224 | 8662591 | |
|
Intra
|
STAT3 | P40763 | STAT1 | Homo sapiens | P42224 | 35140242 | |
|
Intra
|
STAT3 | P40763 | STAT1 | Homo sapiens | P42224 | 25241761 | |
|
Intra
|
STAT3 | P40763 | STAT1 | Homo sapiens | P42224 | 25609649 | |
|
Intra
|
STAT3 | P40763 | BICD1 | Homo sapiens | Q96G01 | 21988832 | |
|
Intra
|
STAT3 | P40763 | POM121 | Homo sapiens | Q96HA1-2 | 32296183 | |
|
Intra
|
STAT3 | P40763 | JAK1 | Homo sapiens | P23458 | 25065853 | |
|
Intra
|
STAT3 | P40763 | CAPN1 | Homo sapiens | P07384 | 21988832 | |
|
Intra
|
STAT3 | P40763 | BLK | Homo sapiens | P51451 | 29892012 | |
|
Intra
|
STAT3 | P40763 | BLK | Homo sapiens | P51451 | 31515488 | |
|
Intra
|
STAT3 | P40763 | BLK | Homo sapiens | P51451 | 25416956 | |
|
Intra
|
STAT3 | P40763 | BLK | Homo sapiens | P51451 | 32296183 | |
|
Intra
|
STAT3 | P40763 | MAPK13 | Homo sapiens | O15264 | 32852592 | |
|
Cross
|
STAT3 | P40763 | Zdhhc19 | Mus musculus | Q810M5 | 31462771 | |
|
Intra
|
STAT3 | P40763 | RET | Homo sapiens | P07949 | 11536047 | |
|
Intra
|
STAT3 | P40763 | SOX1 | Homo sapiens | O00570 | 20929579 | |
|
Intra
|
STAT3 | P40763 | EGFR | Homo sapiens | P00533 | 25241761 | |
|
Intra
|
STAT3 | P40763 | EGFR | Homo sapiens | P00533 | 24135280 | |
|
Intra
|
STAT3 | P40763 | EGFR | Homo sapiens | P00533 | 24135280 | |
|
Intra
|
STAT3 | P40763 | SP1 | Homo sapiens | P08047 | 21184768 | |
|
Intra
|
STAT3 | P40763 | RPS9 | Homo sapiens | P46781 | 21988832 | |
|
Intra
|
STAT3 | P40763 | IMPDH2 | Homo sapiens | P12268 | 32296183 | |
|
Intra
|
STAT3 | P40763 | MAP3K7 | Homo sapiens | O43318 | 15764709 | |
|
Intra
|
STAT3 | P40763 | MAP3K7 | Homo sapiens | O43318 | 15764709 | |
|
Intra
|
STAT3 | P40763 | GADD45GIP1 | Homo sapiens | Q8TAE8 | 18200042 | |
|
Intra
|
STAT3 | P40763 | SULT2A1 | Homo sapiens | Q06520 | 21988832 | |
|
Intra
|
STAT3 | P40763 | MORC4 | Homo sapiens | Q8TE76 | 21988832 | |
|
Intra
|
STAT3 | P40763 | OGDHL | Homo sapiens | Q9ULD0 | 21988832 | |
|
Intra
|
STAT3 | P40763 | EZH2 | Homo sapiens | Q15910 | 23684459 | |
|
Intra
|
STAT3 | P40763 | DIRAS3 | Homo sapiens | O95661 | 21643014 | |
|
Intra
|
STAT3 | P40763 | ERBB2 | Homo sapiens | P04626 | 19372587 | |
|
Intra
|
STAT3 | P40763 | GNL3 | Homo sapiens | Q9BVP2 | 21988832 | |
|
Intra
|
STAT3 | P40763 | GNL3 | Homo sapiens | Q9BVP2 | 21988832 | |
|
Intra
|
STAT3 | P40763 | BMX | Homo sapiens | P51813 | 32296183 | |
|
Intra
|
STAT3 | P40763 | ECH1 | Homo sapiens | Q13011 | 21988832 | |
|
Intra
|
STAT3 | P40763 | MAPK9 | Homo sapiens | P45984 | 20871632 | |
|
Intra
|
STAT3 | P40763 | ECHS1 | Homo sapiens | P30084 | 23416296 | |
|
Intra
|
STAT3 | P40763 | MRPS31 | Homo sapiens | Q92665 | 21988832 | |
|
Intra
|
STAT3 | P40763 | NR4A1 | Homo sapiens | P22736 | 21988832 | |
|
Intra
|
STAT3 | P40763 | NR4A1 | Homo sapiens | P22736 | 21988832 | |
|
Intra
|
STAT3 | P40763 | CSF3R | Homo sapiens | Q99062 | 9864141 | |
|
Intra
|
STAT3 | P40763 | CSF3R | Homo sapiens | Q99062 | 9864141 | |
|
Intra
|
STAT3 | P40763 | LMO2 | Homo sapiens | P25791 | 25416956 | |
|
Intra
|
STAT3 | P40763 | LMO2 | Homo sapiens | P25791 | 25416956 | |
|
Intra
|
STAT3 | P40763 | DAXX | Homo sapiens | Q9UER7 | 16331268 | |
|
Intra
|
STAT3 | P40763 | DAXX | Homo sapiens | Q9UER7 | 16331268 | |
|
Intra
|
STAT3 | P40763 | SYK | Homo sapiens | P43405 | 21516116 | |
|
Intra
|
STAT3 | P40763 | SYK | Homo sapiens | P43405 | 25416956 | |
|
Intra
|
STAT3 | P40763 | SYK | Homo sapiens | P43405 | 20133729 | |
|
Intra
|
STAT3 | P40763 | SYK | Homo sapiens | P43405 | 32296183 | |
|
Intra
|
STAT3 | P40763 | PGR | Homo sapiens | P06401 | 21184768 | |
|
Intra
|
STAT3 | P40763 | PGR | Homo sapiens | P06401 | 21184768 | |
|
Intra
|
STAT3 | P40763 | PTPN1 | Homo sapiens | P18031 | 15821101 | |
|
Cross
|
STAT3 | P40763 | q9dum3_hhv8 | Human herpesvirus 8 | Q9DUM3 | 16364321 | |
|
Cross
|
STAT3 | P40763 | q9dum3_hhv8 | Human herpesvirus 8 | Q9DUM3 | 16364321 |
Recombinant STAT3 Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P70574 | STAT3 Protein, Human (His) | P40763-1 (M1-N175) | ≥ 95%, as determined by reducing SDS-PAGE. |
STAT3 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80281 | Phospho-STAT3 (Ser727) Antibody (YA147) | WB, ICC/IF, IHC-P, IP | Human, Rat, Mouse |
| HY-P80282 | Phospho-STAT3 (Tyr705) Antibody (YA146) | WB, IHC-P, IP | Human, Mouse |
| HY-P80282A | Phospho-STAT3 (Tyr705) Antibody (YA146) (PBS only) | WB, IHC-P, IP | Human, Mouse, Rat |
| HY-P80344 | STAT3 Antibody (YA056) | WB, ICC/IF, IHC-P, IP | Human, Mouse, Rat |
| HY-P80857 | Phospho-STAT3 (Tyr705) Antibody | WB, IHC-P, ICC/IF, IP | Human, Mouse, Rat |
| HY-P80902 | STAT3 Antibody (YA666) | WB, IHC-P | Human, Rat, Mouse |
| HY-P80902A | STAT3 Antibody (YA666)(PBS only) | WB, IHC-P | Human, Mouse, Rat |
| HY-P84300 | STAT3 Antibody (YA3997) | WB, IHC-P, ICC/IF, ELISA | Human, Mouse, Monkey |
| HY-P84300A | STAT3 Antibody (YA3997)(PBS only) | WB, IHC-P, ICC/IF, ELISA | Human, Mouse, Monkey |
| HY-P86382 | STAT3 Antibody (YA6074) | WB, IHC-P, ICC/IF, IP, ELISA | Human, Mouse, Rat |
| HY-P86737 | phospho-STAT3 (Tyr705) Antibody (YA6429) | IHC-P, IHC-F, IF-Tissue | Human, Rat |
| HY-P86737A | phospho-STAT3 (Tyr705) Antibody (YA6429)(PBS only) | IHC-P, IHC-F, IF-Tissue | Human, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Chronic Mucocutaneous Candidiasis |
|
|
| Essential Thrombocythemia |
|
|
| Basal Cell Carcinoma |
|
|
| Hepatoblastoma |
|
|
| Heart Disease |
|
|
| Teratoma |
|
|
| Connective Tissue Disease |
|
|
| Nail Disease |
|
|
| Combined Immunodeficiency |
|
|
| Estrogen-Receptor Positive Breast Cancer |
|
|
| Eye Disease |
|
|
| Autoimmune Lymphoproliferative Syndrome |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Breast Cancer |
|
|
| Rhabdomyosarcoma |
|
|
| Hypereosinophilic Syndrome |
|
|
| Myelofibrosis |
|
|
| Opportunistic Mycosis |
|
|
| Mixed Lacrimal Gland Cancer |
|
|
| Gastrointestinal Stromal Tumor |
|
|
| Echinococcosis |
|
|
| Bone Cancer |
|
|
| Integumentary System Disease |
|
|
| Pertussis |
|
|
| Myocardial Infarction |
|
|
| Skin Papilloma |
|
|
| Retinitis Pigmentosa |
|
|
| Gastric Cancer |
|
|
| High Grade Glioma |
|
|
| Autoimmune Disease Of Gastrointestinal Tract |
|
|
| Squamous Cell Carcinoma, Head And Neck |
|
|
| Behcet Syndrome |
|
|
| Keratoacanthoma |
|
|
| Hepatocellular Adenoma |
|
|
| Chronic Lymphoproliferative Disorder Of Natural Killer Cells |
|
|
| Sezary'S Disease |
|
|
| Peripheral Nervous System Disease |
|
|
| Hypertension, Essential |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Candidiasis |
|
|
| Squamous Cell Carcinoma |
|
|
| T-Cell Acute Lymphoblastic Leukemia |
|
|
| Melanoma |
|
|
| Nervous System Disease |
|
|
| Lymphoma, Hodgkin, Classic |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Cystic Fibrosis |
|
|
| Colonic Benign Neoplasm |
|
|
| Rasopathy |
|
|
| Celiac Disease 1 |
|
|
| Fungal Infectious Disease |
|
|
| Interstitial Lung Disease 2 |
|
|
| Myocarditis |
|
|
| Autoimmune Disease |
|
|
| Colitis |
|
|
| Medulloblastoma |
|
|
| Lung Cancer Susceptibility 3 |
|
|
| Intestinal Benign Neoplasm |
|
|
| Common Variable Immunodeficiency |
|
|
| Renal Cell Carcinoma, Nonpapillary |
|
|
| Ileitis |
|
|
| Felty Syndrome |
|
|
| Diabetes Mellitus |
|
|
| Hypertelorism, Microtia, Facial Clefting Syndrome |
|
|
| Severe Combined Immunodeficiency |
|
|
| Bone Inflammation Disease |
|
|
| Psoriasis |
|
|
| Papilledema |
|
|
| Hyper Ige Syndrome |
|
|
| Cheilitis |
|
|
| Dermatitis |
|
|
| Lymphoma |
|
|
| Isolated Permanent Neonatal Diabetes Mellitus |
|
|
| Aggressive Nk-Cell Leukemia |
|
|
| Myelodysplastic Syndrome |
|
|
| Myeloma, Multiple |
|
|
| Measles |
|
|
| Estrogen-Receptor Negative Breast Cancer |
|
|
| Hypopharynx Cancer |
|
|
| Hypothyroidism |
|
|
| Endometrial Cancer |
|
|
| Lymphoma, Non-Hodgkin, Familial |
|
|
| T-Cell Large Granular Lymphocyte Leukemia |
|
|
| Dilated Cardiomyopathy |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Wilms Tumor 1 |
|
|
| Lung Cancer |
|
|
| Skin Benign Neoplasm |
|
|
| Omenn Syndrome |
|
|
| Leukemia, Acute Myeloid |
|
|
| Hyper Ige Recurrent Infection Syndrome 1 |
|
|
| Breast Adenocarcinoma |
|
|
| Colorectal Cancer |
|
|
| Melanoma, Uveal |
|
|
| Esophageal Cancer |
|
|
| Thymus Gland Disease |
|
|
| Polycythemia Vera |
|
|
| Hepatic Encephalopathy |
|
|
| Hyper-Ige Recurrent Infection Syndrome 1, Autosomal Dominant |
|
|
| Mantle Cell Lymphoma |
|
|
| Multiple Sclerosis |
|
|
| Burkitt Lymphoma |
|
|
| Gastrointestinal System Benign Neoplasm |
|
|
| Leptin Deficiency Or Dysfunction |
|
|
| Skin Disease |
|
|
| Thrombocytopenia |
|
|
| Pheochromocytoma |
|
|
| Glioblastoma |
|
|
| Hepatocellular Carcinoma |
|
|
| Breast Implant-Associated Anaplastic Large Cell Lymphoma |
|
|
| Adenocarcinoma |
|
|
| Osteoporosis |
|
|
| Arthritis |
|
|
| Autosomal Dominant Polycystic Kidney Disease |
|
|
| Plasmablastic Lymphoma |
|
|
| Liver Benign Neoplasm |
|
|
| Hepatitis |
|
|
| Dermatitis, Atopic |
|
|
| Mycosis Fungoides |
|
|
| Aspergillosis |
|
|
| Hepatitis C |
|
|
| Cholangiocarcinoma |
|
|
| Pancreatic Adenocarcinoma |
|
|
| Thrombocytosis |
|
|
| Neuroblastoma |
|
|
| Inflammatory Bowel Disease |
|
|
| Myeloproliferative Neoplasm |
|
|
| Immunodeficiency 35 |
|
|
| Papilloma |
|
|
| Leukemia |
|
|
| Autoimmune Disease Of Skin And Connective Tissue |
|
|
| Hepatitis C Virus |
|
|
| Pancreatic Ductal Carcinoma |
|
|
| Bone Marrow Cancer |
|
|
| Systemic Lupus Erythematosus |
|
|
| Lymphangioma |
|
|
| Erythroleukemia |
|
|
| Lymphoproliferative Syndrome |
|
|
| Cervical Cancer |
|
|
| Hepatitis B |
|
|
| Amyotrophic Lateral Sclerosis 1 |
|
|
| Lymphoid Interstitial Pneumonia |
|
|
| Gallbladder Cancer |
|
|
| Prostate Cancer |
|
|
| Bile Reflux |
|
|
| Brain Cancer |
|
|
| B Cell Deficiency |
|
|
| Hemangioblastoma |
|
|
| Anaplastic Large Cell Lymphoma |
|
|
| Crohn'S Disease |
|
|
| Leukocyte Disease |
|
|
| Mature T-Cell And Nk-Cell Lymphoma |
|
|
| Leukemia, Chronic Lymphocytic |
|
|
| Pancreatic Cancer |
|
|
| Nasopharyngeal Carcinoma |
|
|
| Asthma |
|
|
| Ovarian Cancer |
|
|
| Prion Disease |
|
|
| Bone Squamous Cell Carcinoma |
|
|
| B-Cell Lymphoma |
|
|
| Cervix Carcinoma |
|
|
| Colon Adenoma |
|
|
| Leukemia, Chronic Myeloid |
|
|
| Chromophobe Renal Cell Carcinoma |
|
|
| Acute Promyelocytic Leukemia |
|
|
| Autoimmune Disease, Multisystem, Infantile-Onset, 1 |
|
|
| Autoimmune Enteropathy |
|
|
| Primary Cutaneous T-Cell Non-Hodgkin Lymphoma |
|
|
| Cardiovascular System Disease |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | STAT3 | VGNC | VGNC:46890 |
| Rattus norvegicus | STAT3 | RGD | RGD:3772 |
| Bos taurus | STAT3 | VGNC | VGNC:35371 |
| Mus musculus | STAT3 | MGD | MGI:103038 |
| Felis catus | STAT3 | VGNC | VGNC:65761 |
| Macaca mulatta | STAT3 | VGNC | VGNC:77906 |
| Others | STAT3 | NCBI |