SOX1 - SRY-box transcription factor 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6656

About SOX1

Cytogenetic location: 13q34 Genomic coordinates (GRCh38): 13:112,067,149-112,071,706 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and 20 paralogues.

Summary

This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with Other proteins. In mice, a similar protein regulates the gamma-crystallin genes and is essential for lens development. [provided by RefSeq, Jul 2008]

SOX1 Products (1)

mRNA	Protein	Name
NM_005986.3	NP_005977.2	transcription factor SOX-1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20049565	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20929579	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SOX1 Protein Structure

HMG_box

SOXp

0
100
200
300
391 a.a.

Protein Preferred Names	Protein Names
transcription factor SOX-1	SRY (sex determining region Y)-box 1

SOX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SOX1	O00570	STAT3	Homo sapiens	P40763	Anti Bait CoIP	20929579

Cross: Cross-species interaction Intra: Intraspecies interaction

SOX1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80330	SOX1 Antibody (YA070)	WB, ICC/IF, IHC-P	Human, Mouse, Rat
HY-P87081	SOX1 Antibody (YA6774)	WB, IHC-F, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lambert-Eaton Myasthenic Syndrome	Lambert-Eaton Syndrome Eaton-Lambert Syndrome Lems Lambert Eaton Myasthenic Syndrome Eaton Lambert Syndrome Lambert Eaton Syndrome Myasthenic Syndrome Of Lambert-Eaton Myasthenic-Myopathic Syndrome Of Lambert-Eaton Lems - [Lambert-Eaton Myasthenic Syndrome]
Bilateral Hypoactive Labyrinth	Hypoactive Bilateral Labyrinthine Dysfunction Hypoactive Labyrinth, Bilateral
Inner Ear Disease	Labyrinthine Dysfunction Diseases Of Inner Ear Labyrinthine Disease Abnormality Of The Inner Ear Labyrinth Diseases Labyrinthine Disorder Nonfunctioning Labyrinth Labyrinthine Loss Of Function Labyrinthine Syndrome Labyrinthine Disorder Nos
Paraneoplastic Polyneuropathy
Neuromuscular Junction Disease	Neuromuscular Junction Diseases
Autoimmune Disease Of Peripheral Nervous System
Limbic Encephalitis
Autoimmune Epilepsy
Retinitis Pigmentosa 50	RP50 Retinitis Pigmentosa, Concentric Retinitis Pigmentosa-50 Retinitis Pigmentosa Concentric
Germ Cell And Embryonal Cancer	Germ Cell And Embryonal Neoplasm
Postinfectious Encephalitis	Postinfective Encephalitis Secondary Encephalitis
Cataract 34, Multiple Types	Cataract, Autosomal Recessive Congenital 3 Cataract 34 Multiple Types CTRCT34 Catc3 Cataract 34, Multiple Types, With Or Without Microcornea Autosomal Recessive Congenital Cataract 3 Cataract 34 Multiple Types With Or Without Microcornea Cataract, Multiple Types, Type 34
Germ Cell Cancer	Malignant Germ Cell Tumor Neoplasms, Germ Cell And Embryonal Germ Cell Neoplasm Germ Cell Tumour Malignant Tumor Of The Germ Cell Neoplasms Germ Cell Malignant Germ Cell Neoplasm
Neuromuscular Disease	Neuromuscular Diseases Neuromuscular Disorders Neuromuscular Disorder
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12273	DMH-1	Inhibitor	99.95%	Unkown
HY-133028	CKI-7 free base	Inhibitor	99.31%	Unkown
HY-W011109	CKI-7	Inhibitor	99.97%	Unkown
HY-RS13582	SOX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-12273G	DMH-1 (GMP)	Inhibitor	/	Unkown
HY-RS19383	Sox1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25875	Sox1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SOX1	RGD	RGD:6487636
Bos taurus	SOX1	VGNC	VGNC:35140
Mus musculus	SOX1	MGD	MGI:98357
Canis familiaris	SOX1	VGNC	VGNC:57497
Others	SOX1	NCBI