2. Stem Cell/Wnt TGF-beta/Smad Cytoskeleton Cell Cycle/DNA Damage
  3. Organoid TGF-β Receptor Microtubule/Tubulin
  4. DMH-1

DMH-1 (GMP) is GMP grade DMH-1 (HY-12273). DMH-1 (GMP) is a selective BMP inhibitor. DMH-1 (GMP) upregulates the expression of SOX1. DMH-1 (GMP) increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 (GMP) induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons.

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DMH-1

DMH-1 Chemical Structure

CAS No. : 1206711-16-1

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DMH-1 Related Antibodies

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Description

DMH-1 (GMP) is GMP grade DMH-1 (HY-12273). DMH-1 (GMP) is a selective BMP inhibitor. DMH-1 (GMP) upregulates the expression of SOX1. DMH-1 (GMP) increases cardiomyocyte progenitor cells and promotes the differentiation of mouse embryonic stem cells into cardiomyocytes. DMH-1 (GMP) induces the differentiation of hiPSC-derived neural progenitor cells into β3-tubulin-positive neurons[1][2].

IC50 & Target[1]

BMP

 

In Vitro

DMH-1 (GMP) (0.5 μM) induces the formation of beating embryoid bodies (EBs), with an efficiency of approximately 20% on day 7, peaking at approximately 75% on day 9. Its efficiency at all evaluated time points is significantly higher than that of the DMSO control group[1].
DMH-1 (GMP) (0.5 μM) specifically upregulates the expression profile of canonical cardiogenic genes, including BryT, Mesp1, Isl1 and Nkx2.5, and does not significantly induce the expression of non-cardiomyocyte mesodermal, endodermal or ectodermal markers compared with the DMSO control group[1].
DMH-1 (GMP) (0.5 μM; 24-48 h) does not induce cell apoptosis[1].
DMH-1 (GMP) (0.5-10 μM; 7 days) increases the expression of SOX1 in hiPSCs in a concentration-dependent manner[2].
DMH-1 (GMP) (0.5 μM) induces hiPSC-derived neural progenitor cells to differentiate into β3-tubulin-positive neurons[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DMH-1 Related Antibodies

Real Time qPCR[1]

Cell Line: CGR8 mouse embryonic stem cell-derived EBs
Concentration: 0.5 μM
Incubation Time: from induction, assessed at Day 3, Day 4, Day 6, Day 8, Day 10
Result: Significantly upregulated pre-mesoderm marker BryT (Day 3, Day 4), mesoderm lineage marker Mesp1 (Day 3, Day 4), second heart field marker Isl1 (Day 3, Day 4), and cardiomyocyte-specific marker Nkx2.5 (Day 6, Day 8, Day 10) relative to DMSO vehicle control.
Did not specifically induce hematopoietic marker Gata1, multipotent progenitor marker Kdr/Flk-1, smooth muscle marker Myh11, endoderm markers Sox17 or FoxA2, or ectoderm marker Nestin relative to DMSO vehicle control.
Induced a modest 2.3-fold increase in endocardial marker VE-CAM on Day 10 relative to DMSO.
Molecular Weight

380.44

Formula

C24H20N4O
CAS No.
SMILES

CC(C)OC1=CC=C(C2=CN3C(N=C2)=C(C4=CC=NC5=CC=CC=C45)C=N3)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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DMH-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DMH-1 (GMP)1206711-16-1OrganoidTGF-β ReceptorMicrotubule/TubulinTransforming growth factor beta receptorsALK3human-induced pluripotent stem cellALK1ALK2mouse embryonic stem cellp38 MAPKSmad2Flk1BMP Type 1 receptorALK6Inhibitorinhibitorinhibit

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