Art. -Nr.: HY-136658

STAT3-IN-48

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

STAT3-IN-48 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-48 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-48 does not inhibit kinase activity and has anticancer effects.

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Reinheit: 98.64%
CAS. Nr.: 1313019-65-6
Formel: C₂₁H₁₃ClF₃N₃O₂
Molecular Weight:431.80

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

STAT3-IN-48 Chemical Structure

CAS. Nr.: 1313019-65-6

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Lösungsmittel & Löslichkeit
- In Vitro
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

p-STAT3

Alle STAT Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
PLC-PRF-5	IC₅₀	7.5 μM Compound: 1	Cytotoxicity against human PLC/PRF/5 cells assessed as growth inhibition Cytotoxicity against human PLC/PRF/5 cells assessed as growth inhibition	[PMID: 21531053]

In Vitro

STAT3-IN-48 (SC-1; 1-10 μM; 48 hours; breast cancer cells) treatment demonstrates dose-dependent suppression of cell viability in all tested breast cancer cells^[1].
STAT3-IN-48 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment induces potent apoptotic activity^[1].
STAT3-IN-48 (SC-1; 1-10 μM; 36 hours; breast cancer cells) treatment shows downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration:

1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time:

48 hours
Result:

Demonstrated dose-dependent suppression of cell viability in all tested breast cancer cells.

Apoptosis Analysis^[1]

Cell Line:

HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration:

1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time:

36 hours
Result:

Induced potent apoptotic activity.

Western Blot Analysis^[1]

Cell Line:

HCC-1937, MDA-MB-231, MDA-MB-468, MDA-MB-453, SK-BR3 and MCF-7 cells
Concentration:

1 μM, 2 μM, 5 μM, 7.5 μM, 10 μM
Incubation Time:

36 hours
Result:

Showed downregulation of p-STAT3 and its downstream proteins cyclin D1 and survivin in a dose-dependent manner in breast cancer cell lines.

In Vivo

STAT3-IN-48 (10 mg/kg; oral gavage; daily; for 28 days; female NCr athymic nude mice) treatment shows efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Female NCr athymic nude mice (4-6 weeks of age) injected with breast cancer cells ^[1]
Dosage:

10 mg/kg
Administration:

Oral gavage; daily; for 28 days
Result:

Showed efficacious antitumor activity and p-STAT3 downregulation in MDA-MB-468 xenograft tumors.

Chemical Information

CAS. Nr. 1313019-65-6
Appearance Solid
Molecular Weight 431.80
Formel C₂₁H₁₃ClF₃N₃O₂
Color White to off-white
SMILES

O=C(NC1=CC=C(OC2=CC=C(C#N)C=C2)C=C1)NC3=CC=C(Cl)C(C(F)(F)F)=C3
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Cancer Manag Res

Inhibition of microRNA-15b-5p Attenuates the Progression of Oral Squamous Cell Carcinoma via Modulating the PTPN4/STAT3 Axis. [Abstract]

2020 Oct 28;12:10559-10572. PMID: 33149666

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 250 mg/mL (578.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.3159 mL

11.5794 mL

23.1589 mL

5 mM

0.4632 mL

2.3159 mL

4.6318 mL

10 mM

0.2316 mL

1.1579 mL

2.3159 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chun-Yu Liu, et al. Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast Cancer Res. 2013;15(4):R63. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.3159 mL	11.5794 mL	23.1589 mL	57.8972 mL
	5 mM	0.4632 mL	2.3159 mL	4.6318 mL	11.5794 mL
	10 mM	0.2316 mL	1.1579 mL	2.3159 mL	5.7897 mL
	15 mM	0.1544 mL	0.7720 mL	1.5439 mL	3.8598 mL
	20 mM	0.1158 mL	0.5790 mL	1.1579 mL	2.8949 mL
	25 mM	0.0926 mL	0.4632 mL	0.9264 mL	2.3159 mL
	30 mM	0.0772 mL	0.3860 mL	0.7720 mL	1.9299 mL
	40 mM	0.0579 mL	0.2895 mL	0.5790 mL	1.4474 mL
	50 mM	0.0463 mL	0.2316 mL	0.4632 mL	1.1579 mL
	60 mM	0.0386 mL	0.1930 mL	0.3860 mL	0.9650 mL
	80 mM	0.0289 mL	0.1447 mL	0.2895 mL	0.7237 mL
	100 mM	0.0232 mL	0.1158 mL	0.2316 mL	0.5790 mL

Keywords

STAT3-IN-48

1 Cited Publications

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STAT3-IN-48

Apoptosis Compound Library

Immunology/Inflammation Compound Library

JAK/STAT Compound Library

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Anti-Cancer Compound Library

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Orally Active Compound Library

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Posttranslational Modification Library

Publications Citing Use of MedChemExpress (MCE) STAT3-IN-48

Alle STAT Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (1)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

STAT3-IN-48 Related Classifications

HY-136658 Related Classifications