STAT3 degrader-1
STAT3 degrader-1 is a small-molecule targeted protein degrader that targets STAT3. STAT3 degrader-1 is applicable to studies on STAT3-dependent signaling pathways and leukemia.
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- No. CAS: 2497585-16-5
- Fòrmula: C58H63F5N9O12PS
- Peso molecular:1236.20
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
[1]|
STAT3 |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID mice bearing subcutaneous MOLM-16 xenografts; 5 × 106 cells in 50% Matrigel[1]
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Dosage:50 mg/kg
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Administration:i.v.; 4W
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Result:Markedly suppressed MOLM-16 xenograft tumor growth compared with vehicle.
Chemical Information
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No. CAS 2497585-16-5
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Peso molecular 1236.20
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Fòrmula C58H63F5N9O12PS
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SMILES
FC(C=C1)=CC=C1C[C@H](NC([C@H](CCC(N)=O)NC([C@H]2N3[C@](CCN(C[C@@H](C3=O)NC(C4=CC5=CC(C(F)(F)P(O)(O)=O)=CC=C5S4)=O)CC(F)F)([H])CC2)=O)=O)C(N(CC6)CCC6CCC#CC7=C8C(C(N(C9C(NC(CC9)=O)=O)C8)=O)=CC=C7)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
STAT3 degrader-1 Related Classifications
HY-147048 Related Classifications
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