2. PROTAC Stem Cell/Wnt JAK/STAT Signaling
  3. Ligands for Target Protein for PROTAC STAT
  4. SI-191

SI-191 is a STAT3 inhibitor and a target protein ligand. SI-191 inhibits the growth of cancer cells. SI-191 can be used in the research of acute leukemia and lymphoma. SI-191 can be used for the synthesis of PROTAC SD-91 (HY-150251).

For research use only. We do not sell to patients.

SI-191

SI-191 Chemical Structure

CAS No. : 2754428-37-8

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SI-191 Related Antibodies

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Description

SI-191 is a STAT3 inhibitor and a target protein ligand. SI-191 inhibits the growth of cancer cells. SI-191 can be used in the research of acute leukemia and lymphoma. SI-191 can be used for the synthesis of PROTAC SD-91 (HY-150251)[1].

IC50 & Target[1]

STAT3

 

Cellular Effect
Cell Line Type Value Description References
SU-DHL-1 IC50
>10 μM
Compound: SI-191
Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay
Antiproliferative activity against human SU-DHL-1 cells assessed as cell growth inhibition incubated for 4 days by CellTiter-Glo asssay
[PMID: 34141084]
In Vitro

SI-191 (>10 μM) inhibits the growth of MOLM-16 acute leukemia cells, SU-DHL-1 lymphoma cells, and SUP-M2 lymphoma cells with IC50 values greater than 10 μM for all three cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SI-191 Related Antibodies
Molecular Weight

813.79

Formula

C40H44N7O10P
CAS No.
SMILES

CC(N1CC[C@H]2CC[C@H](N2C([C@H](C1)NC(C3=CC4=CC(C(P(O)(O)=O)=O)=CC=C4N3)=O)=O)C(N[C@H](C(NC(C5=CC=CC=C5)C6=CC=CC=C6)=O)CCC(N)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SI-191 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SI-1912754428-37-8SI191SI 191Ligands for Target Protein for PROTACSTATTarget Protein-binding Moietyleukemia cellsSU-DHL-1 lymphoma cellsSTAT6STAT5SUP-M2 lymphoma cellsSTAT3STAT1STAT4MOLM-16 acute leukemia cellsSTAT2Inhibitorinhibitorinhibit

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SI-191
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HY-150895
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