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Cat. No.: HY-178140

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STAT3-IN-47

STAT3-IN-47 is an orally active STAT3 inhibitor. STAT3-IN-47 exhibits broad-spectrum anti-tumor activity against HeLa, HepG2, U87, and LN229 cells. STAT3-IN-47 suppresses STAT3 activation in vitro. STAT3-IN-47 can be used for the study of solid tumors, especially central nervous system (CNS) malignancies and hepatocellular carcinoma.

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CAS No.: 2787548-58-5
Formule: C₁₅H₈N₄O₃S
Masse moléculaire:324.31

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

STAT3-IN-47 Chemical Structure

CAS No.: 2787548-58-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target^[1]

STAT3

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In Vitro

STAT3-IN-47 (Compound S1) (0.1-10 μM) exhibits broad-spectrum anti-tumor activity against HeLa, HepG2, U87, and LN229 cells, with IC₅₀ values of 5.066 μM, 0.8089 μM, 1.970 μM, and 1.412 μM respectively^[1].
STAT3-IN-47 (0.1-10 μM) suppresses STAT3 activation in a dose-dependent manner in HeLa, HepG2, U87, and LN229 cells^[1].
STAT3-IN-47 (0.5-2 μM) inhibits EGF-induced STAT3 phosphorylation (Y705) in HeLa cells and dose-dependently suppresses IL-6-induced STAT3 phosphorylation (Y705) in HepG2, U87, LN229 cells^[1].
STAT3-IN-47 downregulates stemness-associated genes (Nanog, Oct4, β-catenin) in Huh7, LN229, and HepG2 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	MRT_0-inf	MRT_0-t	AUC_0-t	AUC_0-inf	CL	V_dss	T_max	C_max	F
Rat^[1]	3 mg/kg	i.v.	2.1 h	0.6 h	0.53 h	1040 ng·h/mL	1040 ng·h/mL	49.4 mL/min/kg	1.77 L/kg	/	/	/
Rat^[1]	6 mg/kg	i.g.	2.1 h	4.1 h	4.2 h	186 ng·h/mL	182 ng·h/mL	/	/	1.8 h	31.9 ng/mL	8.8 %

Chemical Information

CAS No. 2787548-58-5
Masse moléculaire 324.31
Formule C₁₅H₈N₄O₃S
SMILES

O=C(C1=C2OC(/C=N/N3C=NNC3=S)=C1)C4=C(C2=O)C=CC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yin K, et al. Discovery of novel 1,2,4-triazole schiff bases hybridized with 1,4-naphthoquinones as potent STAT3 inhibitors. Bioorg Chem. 2025 Aug 30;165:108936. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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STAT3-IN-47

Voir tous les produits spécifiques à Isoform STAT