EGFR kinase-IN-8
EGFR kinase-IN-8 (Compound H8b) is an EGFR inhibitor. EGFR kinase-IN-8 potently inhibits both triple-mutated EGFRL858R/T790M/C797S (IC50 = 3.86 nM) and double-mutated EGFRL858R/T790M (IC50 = 1.23 nM). EGFR kinase-IN-8 suppresses EGFR phosphorylation and downstream AKT, STAT3, and MAPK signaling. EGFR kinase-IN-8 exhibits anticancer activity against non-small cell lung cancer.
For research use only. We do not sell to patients.
- CAS No.: 3081622-35-4
- Formula: C31H40Cl3N8O3P
- Molecular Weight:710.03
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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All EGFR Isoforms
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Biological Activity
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EGFRL858R/T790M 1.23 nM (IC50) |
EGFRL858R/T790M/C797S 3.86 nM (IC50) |
STAT3 |
Chemical Information
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CAS No. 3081622-35-4
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Molecular Weight 710.03
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Formula C31H40Cl3N8O3P
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SMILES
CP(C1=C(C=CC=C1)NC2=C(C=NC(NC3=CC(NC(C(Cl)Cl)=O)=C(C=C3OC)N4CCC(CC4)N5CCN(CC5)C)=N2)Cl)(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EGFR kinase-IN-8 Related Classifications
HY-180922 Related Classifications
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