3081622-35-4
3081622-35-4
Chemical Structure
EGFR kinase-IN-8
- CAS. Nr.: 3081622-35-4
- Formula:C31H40Cl3N8O3P
- Molecular Weight:710.03
InChIKey: WKUTZQYPDRJNAE-UHFFFAOYSA-N
SMILES: CP(C1=C(C=CC=C1)NC2=C(C=NC(NC3=CC(NC(C(Cl)Cl)=O)=C(C=C3OC)N4CCC(CC4)N5CCN(CC5)C)=N2)Cl)(C)=O
Biological Activity: EGFR kinase-IN-8 (Compound H8b) is an EGFR inhibitor. EGFR kinase-IN-8 potently inhibits both triple-mutated EGFRL858R/T790M/C797S (IC50 = 3.86 nM) and double-mutated EGFRL858R/T790M (IC50 = 1.23 nM). EGFR kinase-IN-8 suppresses EGFR phosphorylation and downstream AKT, STAT3, and MAPK signaling. EGFR kinase-IN-8 exhibits anticancer activity against non-small cell lung cancer[1].
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EGFR kinase-IN-8 | EGFR kinase-IN-8 (Compound H8b) is an EGFR inhibitor. EGFR kinase-IN-8 potently inhibits both triple-mutated EGFRL858R/T790M/C797S (IC50 = 3.86 nM) and double-mutated EGFRL858R/T790M (IC50 = 1.23 nM). EGFR kinase-IN-8 suppresses EGFR phosphorylation and downstream AKT, STAT3, and MAPK signaling. EGFR kinase-IN-8 exhibits anticancer activity against non-small cell lung cancer. | |||||||||||||||||||||
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