2. Epigenetics PI3K/Akt/mTOR Autophagy MAPK/ERK Pathway Apoptosis Stem Cell/Wnt JAK/STAT Signaling Vitamin D Related/Nuclear Receptor Immunology/Inflammation NF-κB
  3. AMPK Autophagy mTOR Ribosomal S6 Kinase (RSK) Apoptosis STAT Bcl-2 Family Survivin Glucocorticoid Receptor NF-κB
  4. Avicin D

Avicin D is a plant triterpenoid. Avicin D induces Autophagy by activation of AMPK. Avicin D inhibits mTOR and S6 kinase activity. Avicin D selectively induces Apoptosis and downregulates p-STAT-3, bcl-2, and Survivin. Avicin D has properties of being a selective Glucocorticoid receptor modulator. Avicin D inhibits NF-κB activation. Avicin D shows anti-tumor effects against cutaneous T-cell lymphomas.

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Avicin D

Avicin D Chemical Structure

CAS No. : 197787-20-5

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Avicin D Related Antibodies

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p70S6K RSK2 RSK3 RSK4

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STAT3 STAT5 STAT6 STAT1

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Description

Avicin D is a plant triterpenoid. Avicin D induces Autophagy by activation of AMPK. Avicin D inhibits mTOR and S6 kinase activity. Avicin D selectively induces Apoptosis and downregulates p-STAT-3, bcl-2, and Survivin. Avicin D has properties of being a selective Glucocorticoid receptor modulator. Avicin D inhibits NF-κB activation. Avicin D shows anti-tumor effects against cutaneous T-cell lymphomas[1][2][3].

IC50 & Target[1][2][3]

Bcl-2

 

p-STAT3

 

Molecular Weight

2083.26

Formula

C98H155NO46
CAS No.
SMILES

O=C([C@]([C@@H](C[C@]12C)O)(C[C@@H]3OC(/C(CO)=C/CC[C@@](C=C)(C)O[C@H](O[C@@H]4C)[C@@H]([C@H]([C@@H]4OC(/C(CO)=C/CC[C@@](C)(O)C=C)=O)O)O)=O)[C@](CC(C)3C)([H])C1=CC[C@@]5([H])[C@]2(CC[C@](C(C)6C)([H])[C@@]5(CC[C@@H]6O[C@H](O[C@@H]7CO[C@H](O[C@@H]8C)[C@@H]([C@H]([C@H]8O)O)O[C@H](OC[C@H]9O)[C@@H]([C@H]9O)O)[C@@H]([C@H]([C@@H]7O)O)NC(C)=O)C)C)O[C@H](O[C@@H]%10CO)[C@@H]([C@H]([C@@H]%10O)O)O[C@H](O[C@H]%11C)[C@@H]([C@@H]([C@H]%11O[C@@H]([C@@H]([C@H]%12O)O)O[C@H]%12CO)O[C@@H]([C@@H]([C@H]%13O)O)O[C@@H]([C@H]%13O)CO)O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Avicin D Related Classifications

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Keywords:

Avicin D197787-20-5AMPKAutophagymTORRibosomal S6 Kinase (RSK)ApoptosisSTATBcl-2 FamilySurvivinGlucocorticoid ReceptorNF-κBAMP-activated protein kinaseMammalian target of RapamycinS6KNuclear factor-κBNuclear factor-kappaBcutaneous T-cell lymphomasInhibitorinhibitorinhibit

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