197787-20-5
Chemical Structure
Avicin D
- CAS No.: 197787-20-5
- Formula:C98H155NO46
- Molecular Weight:2083.26
InChIKey: HKEDBKXRDHFCFB-LUAQNYIXSA-N
SMILES: O=C([C@]([C@@H](C[C@]12C)O)(C[C@@H]3OC(/C(CO)=C/CC[C@@](C=C)(C)O[C@H](O[C@@H]4C)[C@@H]([C@H]([C@@H]4OC(/C(CO)=C/CC[C@@](C)(O)C=C)=O)O)O)=O)[C@](CC(C)3C)([H])C1=CC[C@@]5([H])[C@]2(CC[C@](C(C)6C)([H])[C@@]5(CC[C@@H]6O[C@H](O[C@@H]7CO[C@H](O[C@@H]8C)[C@@H]([C@H]([C@H]8O)O)O[C@H](OC[C@H]9O)[C@@H]([C@H]9O)O)[C@@H]([C@H]([C@@H]7O)O)NC(C)=O)C)C)O[C@H](O[C@@H]%10CO)[C@@H]([C@H]([C@@H]%10O)O)O[C@H](O[C@H]%11C)[C@@H]([C@@H]([C@H]%11O[C@@H]([C@@H]([C@H]%12O)O)O[C@H]%12CO)O[C@@H]([C@@H]([C@H]%13O)O)O[C@@H]([C@H]%13O)CO)O
Biological Activity: Avicin D is a plant triterpenoid. Avicin D induces Autophagy by activation of AMPK. Avicin D inhibits mTOR and S6 kinase activity. Avicin D selectively induces Apoptosis and downregulates p-STAT-3, bcl-2, and Survivin. Avicin D has properties of being a selective Glucocorticoid receptor modulator. Avicin D inhibits NF-κB activation. Avicin D shows anti-tumor effects against cutaneous T-cell lymphomas[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Avicin D | Avicin D is a plant triterpenoid. Avicin D induces Autophagy by activation of AMPK. Avicin D inhibits mTOR and S6 kinase activity. Avicin D selectively induces Apoptosis and downregulates p-STAT-3, bcl-2, and Survivin. Avicin D has properties of being a selective Glucocorticoid receptor modulator. Avicin D inhibits NF-κB activation. Avicin D shows anti-tumor effects against cutaneous T-cell lymphomas. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Xu ZX, et al. A plant triterpenoid, avicin D, induces autophagy by activation of AMP-activated protein kinase. Cell Death Differ. 2007 Nov;14(11):1948-57. [Content Brief]
- [2]. Zhang C, et al. Avicin D selectively induces apoptosis and downregulates p-STAT-3, bcl-2, and survivin in cutaneous T-cell lymphoma cells. J Invest Dermatol. 2008 Nov;128(11):2728-2735. [Content Brief]
- [3]. Haridas V, et al. The anticancer plant triterpenoid, avicin D, regulates glucocorticoid receptor signaling: implications for cellular metabolism. PLoS One. 2011;6(11):e28037. [Content Brief]
