2. PROTAC Protein Tyrosine Kinase/RTK Stem Cell/Wnt JAK/STAT Signaling
  3. PROTACs Anaplastic lymphoma kinase (ALK) STAT
  4. PROTAC ALK degrader-5

PROTAC ALK degrader-5 (Compound 17) is an efficient ALK PROTAC degrader, with its inhibitory effects on EML4-ALK and NPM-ALK being 27.4 nM and 116.5 nM respectively. PROTAC ALK degrader-5 exhibits potent anti-proliferative activity against H3122 and Karpas 299. PROTAC ALK degrader-5 effectively inhibits the phosphorylation of ALK and STAT3. PROTAC ALK degrader-5 can be used for the study of ALK-driven malignant tumors, such as human non-small cell lung cancer and anaplastic large cell lymphoma.
(Pink: Anaplastic lymphoma kinase (ALK) Target protein ligand; Blue: Cereblon ligand (HY-14658); Black: linker).

For research use only. We do not sell to patients.

PROTAC ALK degrader-5

PROTAC ALK degrader-5 Chemical Structure

CAS No. : 2379672-57-6

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PROTAC ALK degrader-5 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

PROTAC ALK degrader-5 (Compound 17) is an efficient ALK PROTAC degrader, with its inhibitory effects on EML4-ALK and NPM-ALK being 27.4 nM and 116.5 nM respectively. PROTAC ALK degrader-5 exhibits potent anti-proliferative activity against H3122 and Karpas 299. PROTAC ALK degrader-5 effectively inhibits the phosphorylation of ALK and STAT3. PROTAC ALK degrader-5 can be used for the study of ALK-driven malignant tumors, such as human non-small cell lung cancer and anaplastic large cell lymphoma[1]. (Pink: Anaplastic lymphoma kinase (ALK) Target protein ligand; Blue: Cereblon ligand (HY-14658); Black: linker).

IC50 & Target[1]

STAT3

 

Cereblon

 

Cellular Effect
Cell Line Type Value Description References
KARPAS-299 IC50
42 1
Compound: 17
Antiproliferative activity against ALK-positive human KARPAS-299 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
Antiproliferative activity against ALK-positive human KARPAS-299 cells assessed as inhibition of cell proliferation measured after 72 hrs by MTT assay
[PMID: 34176264]
Molecular Weight

711.77

Formula

C40H37N7O6
CAS No.
SMILES

O=C(N1)C(N2C(C3=CC=CC(NCC(N4CCN(C5=CC(C6(C)C)=C(C(C7=C6NC8=C7C=CC(C#N)=C8)=O)C=C5CC)CC4)=O)=C3C2=O)=O)CCC1=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PROTAC ALK degrader-5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC ALK degrader-52379672-57-6PROTAC ALK degrader5PROTAC ALK degrader 5PROTACsAnaplastic lymphoma kinase (ALK)STATAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246PROTACALK degradationAlectinibanaplastic lymphoma kinasetargeted protein degradationCRBN E3 ligaseKarpas 299 xenograftInhibitorinhibitorinhibit

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PROTAC ALK degrader-5
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