2. Epigenetics Stem Cell/Wnt Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. JAK STAT
  4. SD-1029

SD-1029 is a JAK2/STAT3 inhibitor. SD-1029 inhibits STAT3 nuclear translocation. SD-1029 is an inhibitor of STAT3 activation due to inhibition of JAK2 phosphorylation.

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SD-1029 Chemical Structure

SD-1029 Chemical Structure

CAS No. : 118372-34-2

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Based on 1 publication(s) in Google Scholar

SD-1029 Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE SD-1029

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JAK1 JAK2 JAK3 Tyk2 JAK

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STAT3 STAT5 STAT6 STAT1

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Description

SD-1029 is a JAK2/STAT3 inhibitor[1]. SD-1029 inhibits STAT3 nuclear translocation. SD-1029 is an inhibitor of STAT3 activation due to inhibition of JAK2 phosphorylation[2].

IC50 & Target[1]

STAT3

 

JAK2

 

In Vitro

SD-1029 (10 μM) inhibits EGFP-Stat3 nuclear translocation in BHK-21 and U-2OS cells[1].
SD-1029 (5 and 10 μM; 24 hours) inhibits cell growth and induces apoptosis in OVCAR8TR ovarian cancer cells[1].
SD-1029 (10 μM; 24 hours) suppresses p-Stat3 levels in human breast and ovarian cancer cell lines[1].
SD-1029 inhibits not only JAK2 phosphorylation, but also the phosphorylation of STAT1 and STAT3. SD-1029 strongly inhibits Tyk2 phosphorylation, implicating both JAK2 and Tyk2 as upstream requirements for IL-23-induced IL-23R expression[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SD-1029 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: OVCAR8TR ovarian cancer cells
Concentration: 5 and 10 μM
Incubation Time: 24 hours
Result: Down-regulated cell proliferation, and induced apoptotic cell death.
Treatment resulted in a marked, 20-fold induction of apoptosis in the OVCAR8TR cells that express constitutively activated Stat3.

Western Blot Analysis[1]

Cell Line: MDA-MB-468 and MDA435 (breast cancer), OV1063 (ovarian cancer), and the paclitaxel-resistant ovarian cancer daughter lines, SKOV-3TR and OVCAR8TR.
Concentration: 10 μM
Incubation Time: 24 hours
Result: Led to reduced levels of pStat3.
Molecular Weight

639.25

Formula

C25H32Br2Cl2N2O3
CAS No.
SMILES

O=C1C(C(C2=CC=C(Cl)C(Cl)=C2)C3=C(CCC(CN(C)C)C3=O)O4)=C4CCC1CN(C)C.[H]Br.[H]Br
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SD-1029 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SD-1029118372-34-2SD1029SD 1029JAKSTATJanus kinaseSTAT3nucleartranslocationJAK2phosphorylationInhibitorinhibitorinhibit

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