118372-34-2
118372-34-2
Chemical Structure
SD-1029
- CAS No.: 118372-34-2
- Formula:C25H32Br2Cl2N2O3
- Molecular Weight:639.25
IUPAC Name: 9-(3,4-dichlorophenyl)-2,7-bis((dimethylamino)methyl)-3,4,5,6,7,9-hexahydro-1H-xanthene-1,8(2H)-dione dihydrobromide
InChIKey: INKLAKXQHDQKKZ-UHFFFAOYSA-N
SMILES: O=C1C(C(C2=CC=C(Cl)C(Cl)=C2)C3=C(CCC(CN(C)C)C3=O)O4)=C4CCC1CN(C)C.[H]Br.[H]Br
Biological Activity: SD-1029 is a JAK2/STAT3 inhibitor[1]. SD-1029 inhibits STAT3 nuclear translocation. SD-1029 is an inhibitor of STAT3 activation due to inhibition of JAK2 phosphorylation[2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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SD-1029 | 88.8% | SD-1029 is a JAK2/STAT3 inhibitor. SD-1029 inhibits STAT3 nuclear translocation. SD-1029 is an inhibitor of STAT3 activation due to inhibition of JAK2 phosphorylation. | ||||||||||||||||||||
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References
- [1]. Zhenfeng Duan, et al. SD-1029 inhibits signal transducer and activator of transcription 3 nuclear translocation. Clin Cancer Res. 2006 Nov 15;12(22):6844-52. [Content Brief]
- [2]. Nor Fazila Che Mat, et al. Interleukin-23-induced interleukin-23 receptor subunit expression is mediated by the Janus kinase/signal transducer and activation of transcription pathway in human CD4 T cells. J Interferon Cytokine Res. 2011 Apr;31(4):363-71. [Content Brief]
Keywords
