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Cat. No.: HY-189467

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STAT3-IN-54

STAT3-IN-54 is a STAT3 inhibitor. STAT3-IN-54 induces Apoptosis and G0/G1 cell cycle arrest. STAT3-IN-54 exhibits selective anticancer activity against non-small cell lung cancer cells. STAT3-IN-54 can be used for research on non-small cell lung cancer.

For research use only. We do not sell to patients.

Formula: C₁₇H₁₀BrF₂N₃O₂S
Molecular Weight:438.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

STAT3-IN-54 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

^[1]

STAT3

All STAT Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC50	20.13 μM	Cytotoxicity against human A549 lung adenocarcinoma cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay. Cytotoxicity against human A549 lung adenocarcinoma cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.	42612271
L929	IC50	>500 μM	Cytotoxicity against mouse L929 embryonic fibroblast cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay. Cytotoxicity against mouse L929 embryonic fibroblast cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay.	42612271
A549	IC50	2.04 μM	Inhibition of STAT3 (Tyr705) in human A549 lung adenocarcinoma cells incubated for 24 hrs by in-cell ELISA assay. Inhibition of STAT3 (Tyr705) in human A549 lung adenocarcinoma cells incubated for 24 hrs by in-cell ELISA assay.	42612271

In Vitro

Anti-cancerApoptosisCell Cycle RegulationOthers

Anti-cancer

STAT3-IN-54 (Compound 2r) (24 h) exhibits selective cytotoxicity against A549 lung adenocarcinoma cells with an IC₅₀ of 20.13 μM, while showing no cytotoxicity against L929 mouse embryonic fibroblasts at the tested concentrations^[1].

Apoptosis

Anti-cancer

STAT3-IN-54 (20.13 μM; 24 h) induces early and late apoptosis in A549 lung adenocarcinoma cells^[1].

Cell Cycle Regulation

Anti-cancer

STAT3-IN-54 (20.13 μM; 24 h) induces cell cycle arrest at the G0/G1 phase in A549 lung adenocarcinoma cells^[1].

Others

STAT3-IN-54 (24 h) is a potent STAT3 inhibitor with an IC₅₀ of 2.04 μM in A549 lung adenocarcinoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

A549, L929
Concentration:

Various concentrations
Incubation Time:

24 h
Result:

Exerted cytotoxicity against A549 cells with an IC₅₀ of 20.13 μM.
Exhibited an IC₅₀ of >500 μM against L929 cells.
Achieved a selectivity index of >24.84.

Apoptosis Analysis^[1]

Cell Line:

A549
Concentration:

IC₅₀ concentration
Incubation Time:

24 h
Result:

Induced early apoptosis in 12.95% of A549 cells.
Induced late apoptosis in 6.04% of A549 cells.
Induced total apoptosis of 18.99%.
Induced greater total apoptosis than erlotinib and GSK690693.

Cell Cycle Analysis^[1]

Cell Line:

A549
Concentration:

IC₅₀ concentration
Incubation Time:

24 h
Result:

Induced a cell cycle distribution with 65.84% in G0/G1 phase, 21.01% in S phase, and 5.68% in G2/M phase.

Related Protocols :

Chemical Information

Molecular Weight 438.25
Formula C₁₇H₁₀BrF₂N₃O₂S
SMILES

FC1=CC=C(C2=CSC(N/N=C/C3=C(Br)C=C(OCO4)C4=C3)=N2)C(F)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Altıntop MD, et al. Development of thiazole-hydrazone hybrids for targeted therapy of non-small cell lung cancer. Bioorganic chemistry. 2026 Oct 05;181:110369.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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STAT3-IN-54

All STAT Isoforms

Biological Activity

Description

IC50 & Target

Cellular Effect

In Vitro

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

STAT3-IN-54 Related Classifications

HY-189467 Related Classifications

Bioz

Keywords

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