Glucocorticoid receptor/IL-6-IN-1
Glucocorticoid receptor/IL-6-IN-1 (Compound 35) is a selective dual inhibitor targeting the glucocorticoid receptor (GR) and IL-6 signaling pathway (IC50 values of 120 nM and 59 nM, respectively). Glucocorticoid receptor/IL-6-IN-1 inhibits IL-6-induced JAK/STAT3 phosphorylation, blocking inflammatory cytokine transcription. Glucocorticoid receptor/IL-6-IN-1 is promising for research of inflammatory diseases like rheumatoid arthritis and asthma.
For research use only. We do not sell to patients.
- CAS No.: 1198784-71-2
- Formula: C22H23F4N3O4S
- Molecular Weight:501.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-6 59 nM (IC50) |
STAT3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HFF | IC50 |
59 nM
Compound: 35
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Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production
Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production
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[PMID: 25516791] |
Chemical Information
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CAS No. 1198784-71-2
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Molecular Weight 501.49
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Formula C22H23F4N3O4S
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SMILES
O=C(C1=CC(F)=CC=C1C(C)(CC(CC2=CC3=C(N2)C=NC(S(=O)(C)=O)=C3)(C(F)(F)F)O)C)N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glucocorticoid receptor/IL-6-IN-1 Related Classifications
HY-176876 Related Classifications
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