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Results for "

GR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (30) Adenosine Receptor (1) Adrenergic Receptor (4) Amyloid-β (1) Androgen Receptor (1) Antibiotic (2) Apoptosis (7) Autophagy (4) Bacterial (3) Beta-lactamase (1) Biochemical Assay Reagents (1) Calcineurin (1) Calcium Channel (1) Caspase (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) Drug Metabolite (1) Endogenous Metabolite (1) Estrogen Receptor/ERR (1) Galectin (1) Glucocorticoid Receptor (27) iGluR (2) Integrin (1) Interleukin Related (2) Isotope-Labeled Compounds (9) LXR (1) Melatonin Receptor (2) Mineralocorticoid Receptor (3) MMP (2) Neurokinin Receptor (11) Neuropeptide Y Receptor (2) NF-κB (1) NO Synthase (4) Opioid Receptor (3) Parasite (1) Phosphatase (1) Phosphodiesterase (PDE) (3) PPAR (2) Progesterone Receptor (4) Reactive Oxygen Species (1) SARS-CoV (1) Thrombopoietin Receptor (1) Wnt (2) β-catenin (2)
By Research Areas:	Cancer (19) Cardiovascular Disease (8) Endocrinology (24) Infection (6) Inflammation/Immunology (27) Metabolic Disease (7) Neurological Disease (50)

By Targets:

5-HT Receptor (30)

Adenosine Receptor (1)

Adrenergic Receptor (4)

Amyloid-β (1)

Androgen Receptor (1)

Antibiotic (2)

Apoptosis (7)

Autophagy (4)

Bacterial (3)

Beta-lactamase (1)

Biochemical Assay Reagents (1)

Calcineurin (1)

Calcium Channel (1)

Caspase (1)

DNA/RNA Synthesis (1)

Dopamine Receptor (1)

Drug Metabolite (1)

Endogenous Metabolite (1)

Estrogen Receptor/ERR (1)

Galectin (1)

Glucocorticoid Receptor (27)

iGluR (2)

Integrin (1)

Interleukin Related (2)

Isotope-Labeled Compounds (9)

LXR (1)

Melatonin Receptor (2)

Mineralocorticoid Receptor (3)

MMP (2)

Neurokinin Receptor (11)

Neuropeptide Y Receptor (2)

NF-κB (1)

NO Synthase (4)

Opioid Receptor (3)

Parasite (1)

Phosphatase (1)

Phosphodiesterase (PDE) (3)

PPAR (2)

Progesterone Receptor (4)

Reactive Oxygen Species (1)

SARS-CoV (1)

Thrombopoietin Receptor (1)

Wnt (2)

β-catenin (2)

By Research Areas:

Cancer (19)

Cardiovascular Disease (8)

Endocrinology (24)

Infection (6)

Inflammation/Immunology (27)

Metabolic Disease (7)

Neurological Disease (50)

115

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107691

GR 159897	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide neurokinin 2 (NK₂) receptor antagonist. GR 159897 has little or no affinity for NK₁ and NK₃ receptors. GR 159897 inhibits binding of [ ³H]GR100679 to human NK₂ (hNK₂)-CHO cells and rat colon membranes with pK_is of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects .

HY-101248

GR-46611

5-HT Receptor Cancer

GR-46611 is a 5-HT_1D receptor agonist. GR-46611 can be used in the research of bladder hyperactivity, leukemia .

GR-46611	5-HT Receptor	Cancer
GR-46611 is a 5-HT_1D receptor agonist. GR-46611 can be used in the research of bladder hyperactivity, leukemia .

HY-101367A

GR 55562 dihydrochloride	5-HT Receptor	Neurological Disease
GR 55562 (dihydrochloride) is a selective 5-HT_1B receptor antagonist. GR 55562 can be used for the research of nerve disease .

HY-125862

Glutathione, Reductase baker's yeast EC 1.6.4.2; GR	Calcineurin	Metabolic Disease
Glutathione reductase (EC 1.6.4.2) (EC 1.6.4.2) is a reductase responsible for maintaining the supply of reduced glutathione .

HY-103146

GR125487 sulfamate	5-HT Receptor	Neurological Disease
GR125487 sulfamate is an orally active and selective antagonist of 5-HT₄R. GR125487 sulfamate effectively blocks the cognition enhancing effect. GR125487 sulfamate can be used to study memory disorders, gastrointestinal disorders, mood disorders and urinary tract dysfunction .

HY-W010869

GR 55562 hydrochloride	5-HT Receptor	Neurological Disease
GR 55562 hydrochloride is a selective 5-HT_1B receptor antagonist. GR 55562 hydrochloride can be used for the research of nerve disease .

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease Endocrinology
GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist . GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals .

HY-116046

GR 196429	Melatonin Receptor	Others
GR 196429 is a melatonin receptor agonist with some selectivity for the MT1 subtype. GR 196429 produces both sleep-promoting effects and alterations of circadian rhythm, as well as stimulating melatonin release in mice .

HY-P3853

GR 87389	Neurokinin Receptor	Neurological Disease
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra .

HY-128470

Mitoquidone

GR-30921
Others Cancer

Mitoquidone (GR-30921), a pentacyclic pyrroloquinone, is a potent anticancer agent .
HY-120182

GR 128107

Melatonin Receptor Cancer

GR 128107 is a competitive melatonin receptor antagonist (pK_i: 9.6) .
HY-10051

GR203040

Neurokinin Receptor Neurological Disease

GR203040 is an orally active NK₁ receptor antagonist with a pK_i of 10.3. GR203040 shows potent antiemetic activity .

Mitoquidone GR-30921	Others	Cancer
Mitoquidone (GR-30921), a pentacyclic pyrroloquinone, is a potent anticancer agent .

GR 128107	Melatonin Receptor	Cancer
GR 128107 is a competitive melatonin receptor antagonist (pK_i: 9.6) .

GR203040	Neurokinin Receptor	Neurological Disease
GR203040 is an orally active NK₁ receptor antagonist with a pK_i of 10.3. GR203040 shows potent antiemetic activity .

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity .

HY-101382

GR 103691 1 Publications Verification	Dopamine Receptor	Neurological Disease
GR 103691 is a potent, selective dopamine D₃ receptor antagonist with a K_i value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D₃ over hD₄ and hD₁ sites .

HY-P1278A

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-145128

GR103545

Opioid Receptor Neurological Disease

GR103545 is a potent and selective agonist of the κ-opioid receptor (κ-OR). ¹¹GR103545 is a radiotracer for imaging κ-OR in vivo ^[1]
HY-107747

GR 89696

Opioid Receptor Inflammation/Immunology

GR 89696 is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus .

GR103545	Opioid Receptor	Neurological Disease
GR103545 is a potent and selective agonist of the κ-opioid receptor (κ-OR). ¹¹GR103545 is a radiotracer for imaging κ-OR in vivo ^[1]

GR 89696	Opioid Receptor	Inflammation/Immunology
GR 89696 is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus .

HY-18978

GR79236	Adenosine Receptor	Inflammation/Immunology
GR79236 is a highly potent, selective and orally active adenosine A1 receptor agonist with a K_is of 3.1 nM and 1300 nM for A1 and A2 receptors, respectively. GR79236 has anti-nociceptive and anti-inflammatory actions .

HY-121392

GR 125743	5-HT Receptor	Cardiovascular Disease Neurological Disease
GR 125743 is a selective 5-HT_1B/1D receptor antagonist, with pK_is of 8.85 and 8.31 for wild-type h5-HT_1B and wild-type h5-HT_1D, respectively. GR 125743 is used for the research of Parkinson's disease and cardiovascular diseases .

HY-103152

GR 113808	5-HT Receptor	Neurological Disease Inflammation/Immunology
GR 113808 is a potent and highly selective 5-HT₄ receptor antagonist (pK_b= 8.8). GR 113808 shows 300-fold selectivity over 5-HT_1A, 5-HT_1B, 5-HT_2A, 5-HT_2C and 5-HT₃ receptors .

HY-107747A

GR 89696 free base

Opioid Receptor Inflammation/Immunology

GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus .

GR 89696 free base	Opioid Receptor	Inflammation/Immunology
GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus .

HY-P99515

Xeligekimab GR 1501	Interleukin Related	Inflammation/Immunology
Xeligekimab (GR 1501) is an anti-human interleukin 17A (IL-17A) humanized monoclonal antibody. Xeligekimab inhibits the pro-inflammatory cascade .

HY-107590

GR144053 trihydrochloride

Integrin Cardiovascular Disease

GR 144053 trihydrochloride is a selective and non-peptic GPIIb/IIIa inhibitor (IC₅₀=37 nM) .

GR144053 trihydrochloride	Integrin	Cardiovascular Disease
GR 144053 trihydrochloride is a selective and non-peptic GPIIb/IIIa inhibitor (IC₅₀=37 nM) .

HY-100794

GR127935 hydrochloride
GR127935 hydrochloride is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 hydrochloride can be used in neurological disease research .

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-110390

GR148672X

Others Cardiovascular Disease

GR148672X is a triacyglycerol hydrolase (TGH) inhibitor with an IC₅₀ of 4 nM extracted from patent WO 2001016358 A2.

GR148672X	Others	Cardiovascular Disease
GR148672X is a triacyglycerol hydrolase (TGH) inhibitor with an IC₅₀ of 4 nM extracted from patent WO 2001016358 A2.

HY-B0002

Ondansetron hydrochloride GR 38032 hydrochloride; SN 307 hydrochloride	5-HT Receptor	Neurological Disease
Ondansetron hydrochloride (GR 38032 hydrochloride; SN 307 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.

HY-135747

Gut restricted-7 1 Publications Verification GR-7	Bacterial	Infection
Gut restricted-7 (GR-7) is a potent, covalent and orally active pan-bile salt hydrolase (BSH) inhibitor. Gut restricted-7 has a tissue-selective and is restricted to the gut. Gut restricted-7 decreases gut bacterial BSHs and decreases deconjugated bile acid levels in feces of mice .

HY-14929A

Migalastat hydrochloride GR181413A	Others	Others
Migalastat hydrochloride (GR181413A) is a potent and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC₅₀ of 0.04 μM for human α-Gal A.

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8) .

HY-70050C

Alosetron Hydrochloride GR 68755C; GR 68755 Hydrochloride; GR 68755X Hydrochloride	5-HT Receptor	Neurological Disease
Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC₅₀ at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects .

HY-70050A

Alosetron GR 68755; GR 68755X	5-HT Receptor	Neurological Disease Inflammation/Immunology
Alosetron (GR 68755) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC₅₀ at ~55 nM. Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects .

HY-B0121A

Sumatriptan hydrochloride GR 43175 hydrochloride	5-HT Receptor	Neurological Disease
Sumatriptan hydrochloride (GR 43175) is an orally active 5-HT1 receptor agonist with IC₅₀s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT_1D, 5-HT_1B and 5-HT_1F receptors, respectively. Sumatriptan hydrochloride can be used for migraine headache research .

HY-B0593

Ceftazidime 15+ Cited Publications GR20263	Beta-lactamase Bacterial Antibiotic	Infection
Ceftazidime (GR20263), an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8) .

HY-14929

Migalastat GR181413A free base	Others	Others
Migalastat (GR181413A free base) is an orally active and competitive inhibitor of α-galactosidase A (α-Gal A) with an IC₅₀ of 0.04 μM for human α-Gal A .

HY-B0121B

Sumatriptan 2 Publications Verification GR 43175 free base	5-HT Receptor	Neurological Disease
Sumatriptan (GR 43175) is an orally active 5-HT1 receptor agonist with IC₅₀s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT_1D, 5-HT_1B and 5-HT_1F receptors, respectively. Sumatriptan can be used for migraine headache research .

HY-108620

CDP-840 GR259653X	Phosphodiesterase (PDE)	Inflammation/Immunology
CDP-840 (GR259653X) is a potent, selective and orally active phosphodiesterase IV (PDE IV) inhibitor. CDP-840 inhibits antigen-induced early and late phase bronchoconstriction in conscious squirrel monkeys .

HY-70050CR

Alosetron Hydrochloride (Standard) GR 68755C (Standard); GR 68755 Hydrochloride (Standard); GR 68755X Hydrochloride (Standard)	5-HT Receptor	Neurological Disease
Alosetron (Hydrochloride) (Standard) is the analytical standard of Alosetron (Hydrochloride). This product is intended for research and analytical applications. Alosetron Hydrochloride (GR 68755C) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC₅₀ at ~55 nM. Alosetron Hydrochloride attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects .

HY-B0121

Sumatriptan succinate 2 Publications Verification GR 43175 succinate	5-HT Receptor	Neurological Disease
Sumatriptan succinate (GR 43175) is an orally active 5-HT1 receptor agonist with IC₅₀s of 7.3 nm, 9.3nm and 17.8 nm for 5-HT_1D, 5-HT_1B and 5-HT_1F receptors, respectively. Sumatriptan succinate can be used for migraine headache research .

HY-B0002A

Ondansetron hydrochloride dihydrate 5+ Cited Publications GR 38032 hydrochloride dihydrate; SN 307 hydrochloride dihydrate	5-HT Receptor	Neurological Disease
Ondansetron (GR 38032) hydrochloride dehydrate is an orally active, highly selective and competitive 5-HT₃ receptor antagonist (crosses the blood-brain barrier). Ondansetron hydrochloride dehydrate can be used in studies of preventing nausea and vomiting associated with cancer chemotherapy, radiation therapy and surgery .

HY-B0593A

Ceftazidime pentahydrate 15+ Cited Publications GR20263 pentahydrate
Ceftazidime (GR20263) pentahydrate , an antibiotic, has a broad spectrum activity against Gram-positive and Gram-negative aerobic bacteria. Ceftazidime pentahydrate is also active against Enterobacteriaceae (including β-lactamase-positive strains) and is resistant to hydrolysis by most β-lactamases .

HY-B0002B

Ondansetron 5+ Cited Publications GR 38032; SN 307	5-HT Receptor	Neurological Disease Cancer
Ondansetron (GR 38032; SN 307) is a highly selective 5-HT₃ receptor antagonist, with IC₅₀ value of 103 pM. Ondansetron exerts antiemetic effects by antagonizing 5-HT receptor located on local neurons in the peripheral and central nervous system. Ondansetron suppresses nausea and vomiting caused by chemotherapy and radiation therapy. Ondansetron has orally bioactivity .

HY-14302

Salmeterol 5+ Cited Publications GR33343X	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Salmeterol (GR33343X) is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-12143

Vofopitant dihydrochloride GR 205171A	Neurokinin Receptor	Neurological Disease Endocrinology Cancer
Vofopitant dihydrochloride (GR 205171A) is a potent, selective and orally available tachykinin neurokinin 1(NK1) receptor antagonist, inhibits [ ³H]SP binding to the NK1 receptor with pK_i values of 9.5 and 10.6 in rat and human membranes respectively, acts as a potential broad-spectrum anti-emetic agent .

HY-114440

Belapectin GR-MD-02	Galectin Apoptosis	Cancer
Belapectin (GR-MD-02) is a Galectin-3 (Gal-3) inhibitor. Belapectin drives tumor-induced immunosuppression by inducing T cell Apoptosis. Belapectin promotes tumor regression and improves survival of tumor-bearing mice through a CD8+ T cell-dependent mechanism. Belapectin binds to Gal-3 with affinity K_i of 2.8 μM .

HY-17453

Salmeterol xinafoate 5+ Cited Publications GR 33343X xinafoate	Adrenergic Receptor	Inflammation/Immunology Endocrinology
Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC₅₀s of 9.6, 6.1, and 5.9, respectively .

HY-70050

Alosetron (Hydrochloride(1:X)) GR 68755 (Hydrochloride(1:X)); GR 68755X (Hydrochloride(1:X))	5-HT Receptor	Neurological Disease Inflammation/Immunology
Alosetron (GR 68755) Hydrochloride(1:X) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron Hydrochloride(1:X) is used for the research of irritable bowel syndrome (IBS). Alosetron Hydrochloride(1:X) blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC₅₀ at ~55 nM. Alosetron Hydrochloride(1:X) attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects .

Cat. No.	Product Name	Target	Research Area

HY-P1192

GR-73632	Neurokinin Receptor	Neurological Disease Endocrinology
GR-73632 is a novel tachykinin neurokinin 1 (NK-1) receptor agonist . GR-73632 acts directly on the peripheral terminals of primary sensory neurons through NK1 receptor which convey itch signals .

HY-P1278

GR 64349	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1193

GR 82334	Peptides	Neurological Disease
GR 82334 is a potent and specific reversible tachykinin NK1 receptor antagonist . GR 82334 inhibits substance P-induced sensitization by blocking SP NK1 receptors in naked mole-rats .

HY-P3853

GR 87389	Neurokinin Receptor	Neurological Disease
GR 87389 is a potent NK2 receptor antagonist. GR 87389 antagonized GA 64349-induced smooth muscle strips contractions in a competitive manner in the human detrusor, prostate and prostatic urethra .

HY-P3854

GR 83074	Neurokinin Receptor	Neurological Disease
GR 83074 is a potent and selective NK-2 (Neurokinin Receptor) antagonist with a pK_B of 8.23. GR 83074 is inactive as an NK-3 antagonist and exhibits a 340-fold NK-2/NK-1 selectivity .

HY-P1278A

GR 64349 TFA	Neurokinin Receptor	Neurological Disease
GR 64349 is a potent and highly selective NK₂ receptor peptide antagonist, with an EC₅₀ of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK₁ and NK₃ receptors, respectively .

HY-P1277

GR 94800	Neurokinin Receptor	Neurological Disease
GR 94800 is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P1277A

GR 94800 TFA	Neurokinin Receptor	Neurological Disease
GR 94800 TFA is a potent and selective NK₂ receptor peptide antagonist, with pK_B values of 9.6, 6.4 and 6.0 for NK₂, NK₁ and NK₃ receptors, respectively .

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8) .

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8) .

HY-P5916

VSTx-3 κ-Theraphotoxin-GR4a; Kappa-TRTX-GR4a; Voltage sensor toxin 3; Peptide F	Peptides	Neurological Disease
VSTx-3 is a K_V channel blocker. VSTx-3 is demonstrated to be a potent, TTX-sensitive sodium channel blocker and especially, a potent blocker of NaV1.8 channels (IC₅₀ 0.19 μM for hNaV1.3, 0.43 μM for hNaV1.7 and 0.77 μM for hNaV1.8 channels).

HY-P5124

β-Amyloid peptide(16-20) KLVFF	Amyloid-β	Neurological Disease
β-Amyloid peptide(16-20) is a amino acid sequences (KLVFF) of Amyloid-β (Abeta). β-Amyloid peptide(16-20) is an effective inhibitor of Abeta fibril formation, with RG-/-GR-NH₂ residues added at N- and C-terminal ends to aid solubility) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-W040795

N2-Acetylguanine	Infection Structural Classification Natural Products Classification of Application Fields Source classification Endogenous metabolite Disease Research Fields	DNA/RNA Synthesis Endogenous Metabolite
N2-Acetylguanine is a C2-modified guanine. N2-Acetylguanine binds GR (guanine-guanine riboswitch) with an K_d value of 300 nM. N2-Acetylguanine modulate transcriptional termination. N2-Acetylguanine has the potential for the research of antimicrobial agent .

HY-23119

Sodium thiocyanate, GR, 99% Thiocyanate sodium	Structural Classification Natural Products Classification of Application Fields Animals Source classification Inflammation/Immunology Disease Research Fields	Interleukin Related Reactive Oxygen Species
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine IL-10 levels. Sodium thiocyanate also significantly reduces of ROS formation .

HY-N0835

(20S)-Protopanaxatriol 20(S)-APPT; g-PPT	Cardiovascular Disease Panax ginseng C. A. Meyer Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Plants Disease Research Fields Araliaceae	Glucocorticoid Receptor Estrogen Receptor/ERR LXR Apoptosis
(20S)-Protopanaxatriol is a metabolite of ginsenoside. (20S)-Protopanaxatriol works through the glucocorticoid receptor (GR) and estrogen receptor (ER), and is also a LXRα inhibitor. (20S)-Protopanaxatriol shows a broad spectrum of antitumor effects .

Species:	Human (2) Rat (1) Mouse (2) Cynomolgus (1)
Tag:	His (4) Tag Free (1) GST (2)
Source:	HEK293 (3) Sf9 insect cells (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P7774

	Semaphorin-4D/SEMA4D Protein, Human (713a.a, HEK293, His) rHuCD100, His; Semaphorin-4D; A8; BB18; GR3; CD100	Human	HEK293
	CD100 Protein, Human (HEK293, His) is a protein from the semaphorin family with important roles in the vascular, nervous and immune systems.

HY-P700579

	CAMKIV/CAMK4 Protein, Rat (His) CaM kinase-GR; Calspermin	Rat	E. coli
	CAMKIV/CAMK4 protein, a calcium/calmodulin-dependent kinase, operates within the calcium-triggered CaMKK-CaMK4 signaling cascade, exerting regulatory control through phosphorylation on various transcription activators. It notably influences the activity of CREB1, MEF2D, JUN, and RORA, pivotal players in immune response, inflammation, and memory consolidation. In the thymus, CAMKIV regulates the selection threshold of CD4(+)/CD8(+) double positive thymocytes during T-cell ontogeny. In CD4 memory T-cells, it links T-cell antigen receptor (TCR) signaling to the production of IL2, IFNG, and IL4, achieved through the regulation of CREB and MEF2. CAMKIV further plays a role in the differentiation and survival phases of osteoclasts and dendritic cells (DCs), mediating DCs survival by connecting TLR4 signaling and the temporal expression of BCL2. In hippocampal neuron nuclei, CAMKIV phosphorylates the transcription activator CREB1 on 'Ser-133', contributing to memory consolidation and long-term potentiation (LTP) in the hippocampus. Additionally, CAMKIV can activate MAP kinases MAPK1/ERK2, MAPK8/JNK1, and MAPK14/p38, stimulating transcription through the phosphorylation of ELK1 and ATF2. It also demonstrates the ability to phosphorylate CREBBP, PRM2, MEF2A, and STMN1/OP18 in vitro. Notably, CAMKIV is characterized as a heat-stable, acidic, calmodulin-binding protein. CAMKIV/CAMK4 Protein, Rat (His) is the recombinant rat-derived CAMKIV/CAMK4 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CAMKIV/CAMK4 Protein, Rat (His) is 474 a.a., with molecular weight of 57.2 kDa.

HY-P75457

	CAMKIV/CAMK4 Protein, Mouse (sf9) Calcium/calmodulin-dependent protein kinase type IV; CaMK IV; CAMK4; CAMK; CAMK-GR	Mouse	Sf9 insect cells
	CAMKIV/CAMK4 protein, a calcium/calmodulin-dependent kinase, regulates transcription activators (CREB1, MEF2D, JUN, and RORA) in immune response, inflammation, and memory consolidation. It controls thymocyte selection, TCR signaling, osteoclast and dendritic cell survival, and memory consolidation in hippocampal neurons. It activates MAP kinases, ELK1, ATF2, and potentially participates in spermatogenesis. CAMKIV/CAMK4 Protein, Mouse (sf9) is the recombinant mouse-derived CAMKIV/CAMK4 protein, expressed by Sf9 insect cells , with tag free. and with residual Gly-Pro in N-terminal (not related to functional changes) mutation. The total length of CAMKIV/CAMK4 Protein, Mouse (sf9) is 469 a.a., with molecular weight of ~55 kDa.

HY-P75458

	CAMKIV/CAMK4 Protein, Human (HEK293, GST) Calcium/calmodulin-dependent protein kinase type IV; CaMK IV; CAMK4; CAMK; CAMK-GR	Human	HEK293
	The CAMKIV/CAMK4 protein, a serine/threonine kinase, participates in transcriptional regulation across cell types. Its expression is widespread, with notable levels in the brain (RPKM 7.0), lymph nodes (RPKM 3.7), and 21 other tissues. This suggests its potential involvement in diverse physiological processes across multiple organs. CAMKIV/CAMK4 Protein, Human (HEK293, GST) is the recombinant human-derived CAMKIV/CAMK4 protein, expressed by HEK293 , with N-GST labeled tag. The total length of CAMKIV/CAMK4 Protein, Human (HEK293, GST) is 473 a.a., with molecular weight of ~100 kDa.

HY-P75456

	CAMKIV/CAMK4 Protein, Mouse (sf9, His-GST) Calcium/calmodulin-dependent protein kinase type IV; CaMK IV; CAMK4; CAMK; CAMK-GR	Mouse	Sf9 insect cells
	CAMKIV/CAMK4 protein, a calcium/calmodulin-dependent kinase, regulates transcription activators (CREB1, MEF2D, JUN, and RORA) in immune response, inflammation, and memory consolidation. It controls thymocyte selection, TCR signaling, osteoclast and dendritic cell survival, and memory consolidation in hippocampal neurons. It activates MAP kinases, ELK1, ATF2, and potentially participates in spermatogenesis. CAMKIV/CAMK4 Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived CAMKIV/CAMK4 protein, expressed by Sf9 insect cells, with N-His, N-GST labeled tag. The total length of CAMKIV/CAMK4 Protein, Mouse (sf9, His-GST) is 469 a.a., with molecular weight of ~85 kDa.

HY-P701006

	IFN-gamma Protein, Cynomolgus (HEK293, His) IFN-gamma-R1; CDw119; CD119; IFNGR1; IFNGR; AVP; FLJ45734; IFN-gamma R1; IFN-GR1; type 2	Cynomolgus	HEK293
	IFN-gamma (interferon-gamma) is a type II interferon derived from immune cells such as T cells and NK cells, which can significantly activate effector immune cells and enhance antigen presentation. It affects gene regulation through the JAK-STAT pathway and its receptor IFNGR1. IFN-gamma Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IFN-gamma protein, expressed by HEK293 , with C-His labeled tag. The total length of IFN-gamma Protein, Cynomolgus (HEK293, His) is 142 a.a., with molecular weight of 25-35 kDa.

Cat. No.	Product Name	Chemical Structure

HY-B0002BS

Ondansetron-d5
Ondansetron-d₅ is the deuterium labeled Ondansetron. Ondansetron (GR 38032; SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy.

HY-B0002BS1

Ondansetron-d3
Ondansetron-d₃ is the deuterium labeled Ondansetron[1]. Ondansetron(GR 38032;SN 307) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2].

HY-17453S

Salmeterol-d3 xinafoate
Salmeterol-d₃ (xinafoate) is the deuterium labeled Salmeterol xinafoate. Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively[1].

HY-17453S1

Salmeterol-13C6 xinafoate
Salmeterol- ¹³C₆ (xinafoate) is the ¹³C₆ labeled Salmeterol (xinafoate). Salmeterol (GR 33343X) xinafoate is a potent and selective human β2 adrenoceptor agonist. Salmeterol shows potent stimulation of cAMP accumulation in CHO cells expressing human β2, β1 and β3 adrenoceptors with pEC50s of 9.6, 6.1, and 5.9, respectively.

HY-70050AS

Alosetron-d3

Alosetron-d₃ is a deuterium labeled Alosetron. Alosetron is a serotonin 5HT3-receptor antagonist[1].
HY-B0197AS

Naratriptan-d3 hydrochloride

Naratriptan-d₃ (hydrochloride) is the deuterium labeled Naratriptan, which is a selective 5-HT1 receptor subtype agonist.
HY-70050CS

Alosetron D3 Hydrochloride

Alosetron-d₃ (hydrochloride) is deuterium labeled Alosetron, which is a serotonin 5HT3-receptor antagonist.

HY-B0121BS

Sumatriptan-d6 succinate
Sumatriptan-d6 succinate is the deuterium labeled Sumatriptan succinate. Sumatriptan succinate is an orally active 5-HT1 receptor agonist with K_is of 17 nM, 27 nM and 100 nM for 5-HT1D, 5-HT1B and 5-HT1A receptors, respectively. Sumatriptan succinate can be used for migraine headache research .

HY-B0197S

Naratriptan-d3

Naratriptan-d₃ is the deuterium labeled Naratriptan[1]. Naratriptan is a selective 5-HT1 receptor subtype agonist[2].

HY-B0002S1

Ondansetron-d6 hydrochloride
Ondansetron-d₆ (hydrochloride) is the deuterium labeled Ondansetron hydrochloride[1]. Ondansetron hydrochloride is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[2][3][4][5][6][7].

HY-B0002BS2

Ondansetron-13C,d3

Ondansetron- ¹³C,d₃ is the ¹³C- and deuterium labeled Ondansetron[1].

HY-12142S

rac-Vofopitant-d3
rac-Vofopitant-d₃ (rac-GR 205171-d₃)is the deuterium labeledVofopitant(HY-12142) . Vofopitant is potent tachykinin NK₁ receptor antagonist, with pK_is of 10.6, 9.5, and 9.8 for human, rat and ferret NK₁ receptor, respectively .

HY-13683S

Mifepristone-d3
Mifepristone-d₃ is the deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

HY-B0002S

Ondansetron-d3 hydrochloride
Ondansetron-d₃ (hydrochloride) is the deuterium labeled Ondansetron hydrochloride. Ondansetron hydrochloride (GR 38032 hydrochloride) is a serotonin 5-HT3 receptor antagonist used mainly as anantiemetic (to treat nausea and vomiting), often following chemotherapy[1][2].

HY-13683S1

Mifepristone-13C,d3

Mifepristone- ¹³C,d₃ is the ¹³C- and deuterium labeled Mifepristone. Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1]. Mifepristone-13C,d3 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-111372S

Finerenone-d3

Finerenone-d3 is the deuterium labeled finerenone (HY-111372). Finerenone is a third-generation, selective, and orally available nonsteroidal mineralocorticoid receptor (MR) antagonist (IC₅₀=18 nM). Finerenone displays excellent selectivity versus glucocorticoid receptor (GR), androgen receptor (AR), and progesterone receptor (>500-fold). Finerenone has the potential for cardiorenal diseases research, such as type 2 diabetes mellitus and chronic kidney disease .

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