2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. GR-46611

GR-46611 is a 5-HT1D receptor agonist. GR-46611 can be used in the research of bladder hyperactivity, leukemia.

For research use only. We do not sell to patients.

GR-46611 Chemical Structure

GR-46611 Chemical Structure

CAS No. : 185259-85-2

Size Price Stock Quantity
1 mg USD 57 In-stock
5 mg USD 105 In-stock
10 mg USD 170 In-stock
25 mg USD 340 In-stock
50 mg USD 540 In-stock
100 mg   Get quote  
200 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

GR-46611 Related Antibodies

Top Publications Citing Use of Products

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

GR-46611 is a 5-HT1D receptor agonist. GR-46611 can be used in the research of bladder hyperactivity, leukemia[1][3].

IC50 & Target[1]

5-HT1D Receptor

 

In Vitro

GR-46611 (1 μM, 48 h) induces CEM cell proliferation[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GR-46611 Related Antibodies

Cell Proliferation Assay[2]

Cell Line: CEM cells (human T lymphoblastic leukemia cell line)
Concentration: 1 μM
Incubation Time: 48 h
Result: Induced a significant increase in cell proliferation by 37.0%.
In Vivo

GR-46611 (1 mg/kg, i.p. ) significantly improves survival of Dravet syndrome (DS) mice[1].
GR-46611 (0.03-300 μg/kg, i.v.) increases threshold volume, bladder capacity, and residual volume in chronic spinal cord injury (SCI) cats[3].
GR46611 (3-30 mg/kg, s.c.) causes a dose-related decrease in rectal temperature in the adult guinea-pig[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Dravet syndrome (DS) mice[1]
Dosage: 0.01, 0.1 and 1 mg/kg
Administration: Intraperitoneal injection (i.p.)
Result: Improved survival relative to vehicle treated controls with 89% surviving rate.
Molecular Weight

377.48

Formula

C23H27N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=C(OC)C=C1)/C=C/C2=CC3=C(NC=C3CCN(C)C)C=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (264.91 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6491 mL 13.2457 mL 26.4915 mL
5 mM 0.5298 mL 2.6491 mL 5.2983 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6491 mL 13.2457 mL 26.4915 mL 66.2287 mL
5 mM 0.5298 mL 2.6491 mL 5.2983 mL 13.2457 mL
10 mM 0.2649 mL 1.3246 mL 2.6491 mL 6.6229 mL
15 mM 0.1766 mL 0.8830 mL 1.7661 mL 4.4152 mL
20 mM 0.1325 mL 0.6623 mL 1.3246 mL 3.3114 mL
25 mM 0.1060 mL 0.5298 mL 1.0597 mL 2.6491 mL
30 mM 0.0883 mL 0.4415 mL 0.8830 mL 2.2076 mL
40 mM 0.0662 mL 0.3311 mL 0.6623 mL 1.6557 mL
50 mM 0.0530 mL 0.2649 mL 0.5298 mL 1.3246 mL
60 mM 0.0442 mL 0.2208 mL 0.4415 mL 1.1038 mL
80 mM 0.0331 mL 0.1656 mL 0.3311 mL 0.8279 mL
100 mM 0.0265 mL 0.1325 mL 0.2649 mL 0.6623 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

GR-46611 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GR-46611185259-85-2GR46611GR 466115-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorDravet syndromeDS miceseizureepilepsyrapheserotoninCEMleukemiaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
GR-46611
Cat. No.:
HY-101248
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

Request for HNMR Report

We have received your request and will respond to you as soon as possible.