GR 89696 free base
GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus.
For research use only. We do not sell to patients.
- CAS No.: 126766-31-2
- Formula: C19H25Cl2N3O3
- Molecular Weight:414.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
GR-896960 free base (subcutaneous injection, 1 mg/kg) reduces cerebral artery infarct volume by 38% in a rat model of permanent focal ischemia[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 126766-31-2
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Molecular Weight 414.33
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Formula C19H25Cl2N3O3
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SMILES
O=C(N1CCN(C(CN2CCCC2)C1)C(CC3=CC=C(C(Cl)=C3)Cl)=O)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Mei-Chuan Ko, et al. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther. 2009 Jan;328(1):193-200. [Content Brief]
[2]. A Barber, et al. Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat. Methods Find Exp Clin Pharmacol. 1999 Mar;21(2):105-13 [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GR 89696 free base Related Classifications
HY-107747A Related Classifications
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