GR 89696 free base

Cat. No.: HY-107747A: FAQs
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GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus.

For research use only. We do not sell to patients.

GR 89696 free base Chemical Structure

CAS No. : 126766-31-2

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GR 89696

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Description	GR 89696 free base is a highly selective κ2 opioid receptor agonist with potential to prevent pruritus^[1].
In Vivo	GR 89696 free base (intramuscular injection, 0.01-0.1 μg/kg) attenuates the scratching response induced by intrathecal morphine (0.03mg) in a dose-dependent manner without affecting the analgesic effect of morphine^[1]. GR-896960 free base (subcutaneous injection, 1 mg/kg) reduces cerebral artery infarct volume by 38% in a rat model of permanent focal ischemia^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	414.33
Formula	C₁₉H₂₅Cl₂N₃O₃
CAS No.	126766-31-2
SMILES	O=C(N1CCN(C(CN2CCCC2)C1)C(CC3=CC=C(C(Cl)=C3)Cl)=O)OC
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Mei-Chuan Ko, et al. Effects of atypical kappa-opioid receptor agonists on intrathecal morphine-induced itch and analgesia in primates. J Pharmacol Exp Ther. 2009 Jan;328(1):193-200. [Content Brief] [2]. A Barber, et al. Effects of GR-89696 and the novel peripherally selective OP2 agonists, EMD-61569 and EMD-61747, against focal cerebral ischemia in the rat. Methods Find Exp Clin Pharmacol. 1999 Mar;21(2):105-13 [Content Brief]

GR 89696 free base Related Classifications

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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GR 89696126766-31-2GR89696GR-89696Opioid Receptorκ2 opioid receptorpruritusInhibitorinhibitorinhibit

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GR 89696 free base

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