1. GPCR/G Protein
  2. Glucocorticoid Receptor
  3. AZD5423

AZD5423 

Cat. No.: HY-108243
Handling Instructions

AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma.

For research use only. We do not sell to patients.

AZD5423 Chemical Structure

AZD5423 Chemical Structure

CAS No. : 1034148-04-3

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Description

AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM)[1]. AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma[2].

IC50 & Target

Glucocorticoid receptor[1]

In Vitro

The affinity of AZD5423 to the glucocorticoid receptor is high with an IC50 of 0.9 nM in a radioligand human glucocorticoid receptor assay, and selectivity towards other steroid hormone receptors is >900-fold[1].

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

487.45

Formula

C₂₅H₂₁F₄N₃O₃

CAS No.

1034148-04-3

SMILES

O=C(N[[email protected]@H](C)[[email protected]](OC1=CC2=C(N(C3=CC=C(F)C=C3)N=C2)C=C1)C4=CC=CC(OC)=C4)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
AZD5423
Cat. No.:
HY-108243
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AZD5423

Cat. No.: HY-108243