1034148-04-3
1034148-04-3
Chemical Structure
AZD5423
- CAS No.: 1034148-04-3
- Formula:C25H21F4N3O3
- Molecular Weight:487.45
IUPAC Name: 2,2,2-trifluoro-N-((1R,2S)-1-((1-(4-fluorophenyl)-1H-indazol-5-yl)oxy)-1-(3-methoxyphenyl)propan-2-yl)acetamide
InChIKey: FCNQMDSJHADDFT-WNSKOXEYSA-N
SMILES: O=C(N[C@@H](C)[C@H](OC1=CC2=C(N(C3=CC=C(F)C=C3)N=C2)C=C1)C4=CC=CC(OC)=C4)C(F)(F)F
Biological Activity: AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM)[1]. AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma[2].
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AZD5423 | 99.81% | AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma. | ||||||||||||||||||||
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AZD5423 (Standard) | AZD5423 (Standard) is the analytical standard of AZD5423 (HY-108243). This product is intended for research and analytical applications. AZD5423 is an inhaled, potent, selective, and non-steroidal glucocorticoid receptor (GR) modulator (SGRM). AZD5423 effectively reduces allergen-induced responses in subjects with mild allergic asthma. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.69
HY-113854AZD2906 -
Similarity Score 0.63
HY-142942Glucocorticoid receptor-IN-2 -
Similarity Score 0.62
HY-120012Mizacorat -
Similarity Score 0.59
HY-111453Velsecorat -
Similarity Score 0.53
HY-142941Glucocorticoid receptor-IN-1 -
Similarity Score 0.48
HY-117248SR-3737 -
Similarity Score 0.46
HY-146160PARP-1/HDAC-IN-1 -
Similarity Score 0.45
HY-155362Tubulin polymerization-IN-56 -
Similarity Score 0.45
HY-19947PF-06291874 -
Explore the MedChemAI to find more analogs
References
- [1]. Werkström V, et al. Safety, Pharmacokinetics and Pharmacodynamics of the Selective Glucocorticoid Receptor Modulator AZD5423 after Inhalation in Healthy Volunteers. Basic Clin Pharmacol Toxicol. 2016 Dec;119(6):574-581. [Content Brief]
- [2]. Gauvreau GM, et al. A nonsteroidal glucocorticoid receptor agonist inhibits allergen-induced late asthmatic responses. Am J Respir Crit Care Med. 2015 Jan 15;191(2):161-7. [Content Brief]
